Results 181 to 190 of about 1,614,514 (332)

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update

Clinical pharmacology and therapy, 2018
U. Amstutz, L. Henricks, S. Offer, Julia M. Barbarino, J. Schellens, J. Swen, T. Klein, H. McLeod, K. Caudle, R. Diasio, M. Schwab   +10 more
semanticscholar   +1 more source

Genome‐Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes

Advanced Science, EarlyView.
This study explores genome‐wide by lifetime environment interactions on brain imaging phenotypes. Gene‐environment interactions explain more phenotypic variance than main effects, pinpoint regulatory variants, and reveal exposure‐specific biological pathways.
Sijia Wang, Meiyun Wang, Peng Zhang, Jingliang Cheng, Longjiang Zhang, Wenzhen Zhu, Shijun Qiu, Zuojun Geng, Guangbin Cui, Yongqiang Yu, Weihua Liao, Xi‐Nian Zuo, Hui Zhang, Bo Gao, Xiaojun Xu, Tong Han, Zhenwei Yao, Quan Zhang, Feng Liu, Qiang Xu, Jiayuan Xu, Jilian Fu, Nana Liu, Yuan Ji, Jie Tang, Lining Guo, Mengge Liu, Xiaoxiao Xiao, Xiaoxuan Liu, Wei Li, Caihong Wang, Wei Wei, Dapeng Shi, Su Lui, Zhihan Yan, Feng Chen, Jing Zhang, Wen Shen, Yanwei Miao, Dawei Wang, Jia‐Hong Gao, Yunjun Yang, Kai Xu, Junfang Xian, Bing Zhang, Xiaochu Zhang, Zhaoxiang Ye, Le Yu, Wen Qin, Meng Liang, Chunshui Yu, the CHIMGEN Consortium   +51 more
wiley   +1 more source

<i>MTHFR</i> 677C/T gene polymorphism and dietary habits: effects on trace element levels, amino acids, and biochemical parameters. [PDF]

Front Nutr
Orct T, Kovačić J, Peremin I, Kljaković-Gašpić Z, Pašalić D, Sekovanić A, Dorotić A, Tariba Lovaković B, Jurič A, Pizent A, Crnjac F, Dukić L, Gerić M, Jakaša I, Gajski G.   +14 more
europepmc   +1 more source

Analyses of a Ceftazidime-Avibactam-Resistant Citrobacter freundii Isolate Carrying bla _KPC-2 Reveals a Heterogenous Population and Reversible Genotype

, 2018
Mariana Castanheira, S J Ryan Arends, Andrew P. Davis, Leah N. Woosley, Amira A. Bhalodi, Shawn H. MacVane   +5 more
openalex   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

The role of pharmacogenetics in the therapy regimen of acute lymphoblastic leukemia in children: recent discoveries and future perspectives. [PDF]

Pharmacol Rep
Szoszkiewicz A, Światłowska A, Derwich K, Jamsheer A, Rubiś B, Bienert A.   +5 more
europepmc   +1 more source

Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2018
C. Gardner, J. Trepanowski, Liana C. Del Gobbo, Michelle E. Hauser, J. Rigdon, J. Ioannidis, M. Desai, A. King   +7 more
semanticscholar   +1 more source

IL1R2 Marks and Sorts a Spermatogonial Stem Cell Population Critical for Restoring Spermatogenesis Upon Interruption in Mammals

Advanced Science, EarlyView.
Spermatogonial stem cells (SSCs) provide critical support to spermatogenesis. Here, the author established Il1r2 as a sorting marker for SSCs, with which further insights into the SSC heterogeneity and dynamic features can be obtained. They also confirmed findings in both mouse and human, thus validating IL1R2 as the surface marker for isolating and ...
Pengyu Li, Zexuan Zhang, Zihan Xie, Cheng Jin, Zhipeng Wang, Changwei Yuan, Jun Zhu, Jielin Tang, Mengzhen Li, Dingfeng Zou, Xinyu Mang, Jun Liu, Dingyao Chen, Qi Geng, Yan Lu, Ning Zhang, Shiying Miao, Jing Peng, Kai Li, Wei Song   +19 more
wiley   +1 more source

Boceprevir for Untreated Chronic HCV Genotype 1 Infection

New England Journal of Medicine, 2011
Sprint Investigators
semanticscholar   +2 more sources

Beyond the Bottleneck: Predicting Regeneration Potential in Sunflower Through Integrated Morphological and Statistical Profiling. [PDF]

Int J Mol Sci
Ionas K, Vukosavljev M, Bulić E, Radanović A, Jocić S, Kondić-Špika A, Miladinović D.   +6 more
europepmc   +1 more source