Results 11 to 20 of about 2,216,855 (328)
Clinical pharmacology and therapy, 2022 CYP2C19 catalyzes the bioactivation of the antiplatelet prodrug clopidogrel, and CYP2C19 genotype impacts clopidogrel active metabolite formation. CYP2C19 intermediate and poor metabolizers who receive clopidogrel experience reduced platelet inhibition ...
Craig R. Lee +16 more
semanticscholar +1 more source
The Genotype-Tissue Expression (GTEx) project
Nature Genetics, 2013 Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown.
J. Lonsdale +126 more
semanticscholar +1 more source
Inference of population structure using multilocus genotype data: dominant markers and null alleles
Molecular Ecology Notes, 2007 Dominant markers such as amplified fragment length polymorphisms (AFLPs) provide an economical way of surveying variation at many loci. However, the uncertainty about the underlying genotypes presents a problem for statistical analysis.
D. Falush, M. Stephens, J. Pritchard
semanticscholar +1 more source
PLoS Genetics, 2009 Genotype imputation methods are now being widely used in the analysis of genome-wide association studies. Most imputation analyses to date have used the HapMap as a reference dataset, but new reference panels (such as controls genotyped on multiple SNP ...
Bryan N. Howie, P. Donnelly, J. Marchini
semanticscholar +1 more source
Grain Characteristics, Chemical Composition, and Functional Properties of Rye (Secale cereale L.) As Influenced by Genotype and Harvest Year [PDF]
, 2004 Grain characteristic, chemical composition, and functional properties of rye were measured in 19 different cultivars grown in one location in up to 3 years.
Andersen, S.B. +4 more
core +1 more source
PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations
Bioinform., 2019 Summary PhenoScanner is a curated database of publicly available results from large-scale genetic association studies in humans. This online tool facilitates ‘phenome scans’, where genetic variants are cross-referenced for association with many ...
M. Kamat +7 more
semanticscholar +1 more source
Acanthamoeba genotype T4 from the UK and Iran and isolation of the T2 genotype from clinical isolates [PDF]
, 2005 The majority of the keratitis-causing Acanthamoeba isolates are genotype T4. In an attempt to determine whether predominance of T4 isolates in Acanthamoeba keratitis is due to greater virulence or greater prevalence of this genotype, Acanthamoeba ...
Alsam +21 more
core +1 more source
Formation of modules in a computational model of embryogeny [PDF]
, 2005 An investigation is conducted into the effects of a complex mapping between genotype and phenotype upon a simulated evolutionary process. A model of embryogeny is utilised to grow simple French flag like patterns.
Bowers, Chris P.
core +1 more source
Tailored second line therapy in asthmatic children with the arginine-16 genotype [PDF]
, 2012 The arginine-16 beta-2 receptor genotype confers increased susceptibility to exacerbations in asthmatic children taking regular long acting beta-2 agonists.
Aziz +27 more
core +1 more source
Including copy number variation in association studies to predict genotypic values [PDF]
, 2010 The objective of this study was to investigate, both empirically and deterministically, the ability to explain genetic variation resulting from a copy number polymorphism (CNP) by including the CNP, either by its genotype or by a continuous derivation ...
Calus, M.P.L. +2 more
core +2 more sources