Results 11 to 20 of about 1,614,514 (332)

Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update

Clinical pharmacology and therapy, 2022
CYP2C19 catalyzes the bioactivation of the antiplatelet prodrug clopidogrel, and CYP2C19 genotype impacts clopidogrel active metabolite formation. CYP2C19 intermediate and poor metabolizers who receive clopidogrel experience reduced platelet inhibition ...
Craig R. Lee, Jasmine A. Luzum, K. Sangkuhl, Roseann S. Gammal, M. Sabatine, C. Stein, D. Kisor, N. Limdi, Yee Ming Lee, S. Scott, J. Hulot, D. Roden, A. Gaedigk, K. Caudle, T. Klein, Julie A. Johnson, A. Shuldiner   +16 more
semanticscholar   +1 more source

Highly lethal genotype I and II recombinant African swine fever viruses detected in pigs

Nature Communications, 2023
African swine fever virus (ASFV) poses a great threat to the global pig industry and food security. Currently, 24 ASFV genotypes have been reported but it is unclear whether recombination of different genotype viruses occurs in nature.
Dongmin Zhao, En C Sun, Lianyu Huang, Leilei Ding, Yuanmao Zhu, Jiwen Zhang, Dongdong Shen, Xianfeng Zhang, Zhenjiang Zhang, Tao Ren, Wan Wang, Fang Li, Xijun He, Z. Bu   +13 more
semanticscholar   +1 more source

The Genotype-Tissue Expression (GTEx) project

Nature Genetics, 2013
Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown.
J. Lonsdale, Jeffrey A. Thomas, Mike Salvatore, R. Phillips, E. Lo, Saboor Shad, R. Hasz, Gary Walters, Fernando García, Nancy Young, B. Foster, Michael Moser, E. Karasik, Bryan M. Gillard, Kimberley D. Ramsey, Susan Sullivan, J. Bridge, Harold Magazine, John Syron, Johnelle Fleming, L. Siminoff, H. Traino, M. Mosavel, Laura K. Barker, S. Jewell, D. Rohrer, D. Maxim, Dana Filkins, P. Harbach, Eddie Cortadillo, Bree D. Berghuis, L. Turner, E. Hudson, Kristin Feenstra, L. Sobin, J. Robb, Phillip Branton, G. Korzeniewski, C. Shive, D. Tabor, L. Qi, K. Groch, S. Nampally, Stephen A. Buia, Angela M. Zimmerman, Anna Smith, R. Burges, Karna L. Robinson, Kimberly M. Valentino, Debra Bradbury, M. Cosentino, Norma Diaz-Mayoral, M. Kennedy, T. Engel, Penelope Williams, Kenyon Erickson, K. Ardlie, W. Winckler, G. Getz, D. DeLuca, D. MacArthur, Manolis Kellis, Alexander Thomson, Taylor R. Young, Ellen T. Gelfand, M. Donovan, Y. Meng, George B. Grant, D. Mash, Yvonne Marcus, Margaret J. Basile, Jun Liu, Jun Zhu, Zhidong Tu, N. Cox, Dan L. Nicolae, E. Gamazon, H. Im, A. Konkashbaev, J. Pritchard, Matthew Stevens, T. Flutre, Xiaoquan Wen, E. Dermitzakis, T. Lappalainen, R. Guigó, Jean Monlong, M. Sammeth, D. Koller, A. Battle, S. Mostafavi, M. McCarthy, Manual Rivas, J. Maller, I. Rusyn, A. Nobel, F. Wright, A. Shabalin, M. Feolo, N. Sharopova, Anne Sturcke, J. Paschal, James M. Anderson, E. Wilder, L. Derr, E. Green, J. Struewing, Gary F. Temple, S. Volpi, Joy T. Boyer, E. Thomson, M. Guyer, C. Ng, Assya Abdallah, Deborah Colantuoni, T. Insel, S. Koester, A. Little, P. Bender, T. Lehner, Yin Yao, C. Compton, J. Vaught, Sherilyn J. Sawyer, N. Lockhart, J. Demchok, H. Moore   +126 more
semanticscholar   +1 more source

Inference of population structure using multilocus genotype data: dominant markers and null alleles

Molecular Ecology Notes, 2007
Dominant markers such as amplified fragment length polymorphisms (AFLPs) provide an economical way of surveying variation at many loci. However, the uncertainty about the underlying genotypes presents a problem for statistical analysis.
D. Falush, M. Stephens, J. Pritchard
semanticscholar   +1 more source

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

PLoS Genetics, 2009
Genotype imputation methods are now being widely used in the analysis of genome-wide association studies. Most imputation analyses to date have used the HapMap as a reference dataset, but new reference panels (such as controls genotyped on multiple SNP ...
Bryan N. Howie, P. Donnelly, J. Marchini
semanticscholar   +1 more source

PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations

Bioinform., 2019
Summary PhenoScanner is a curated database of publicly available results from large-scale genetic association studies in humans. This online tool facilitates ‘phenome scans’, where genetic variants are cross-referenced for association with many ...
M. Kamat, James A. Blackshaw, R. Young, P. Surendran, S. Burgess, J. Danesh, A. Butterworth, James R. Staley   +7 more
semanticscholar   +1 more source

Comparison of live weight and body measurements of adult brood mares from different genotypes in Hungary [PDF]

Journal of Central European Agriculture, 2014
Live weight and 21 body measurements of 110 Thoroughbred, 75 Gidran, 109 Nonius, 97 Hungarian Sport Horse, 172 Hungarian Cold Blooded Horse and 20 Murinsulaner type adult brood mares in 28 studs were evaluated in Hungary.
Szabolcs Bene, Borbala Kecskes, Peter Polgar , Ferenc SZABo   +3 more
doaj   +1 more source

Assessment of Seed Viability Before and After Storage in Forage Pea (Pisum sativum L. var. arvense) Using Field and Laboratory Methods

Plants
This study aimed to evaluate the effects of different storage conditions on seed viability, vigor, and agronomic performance in six forage pea (Pisum sativum L. var. arvense) cultivars: Uysal, Özkaynak, Kurtbey, Ürünlü, Taşkent, and Nany.
Serhat Akyüz, Emine Serap Kizil Aydemir, Serkan Ateş   +2 more
doaj   +1 more source

Virulence of Japanese Encephalitis Virus Genotypes I and III, Taiwan

Emerging Infectious Diseases, 2017
The virulence of genotype I (GI) Japanese encephalitis virus (JEV) is under debate. We investigated differences in the virulence of GI and GIII JEV by calculating asymptomatic ratios based on serologic studies during GI- and GIII-JEV endemic periods. The
Yi-Chin Fan, Jen-Wei Lin, Shu-Ying Liao, Jo-Mei Chen, Yi-Ying Chen, Hsien-Chung Chiu, Chen-Chang Shih, Chi-Ming Chen, Ruey-Yi Chang, Chwan-Chuen King, Wei-June Chen, Yi-Ting Ko, Chao-Chin Chang, Shyan-Song Chiou   +13 more
doaj   +1 more source

Assessment of the Efficiency of Combined Seeding Rates of Common Vetch and Ryegrass for Controlling Weed Development in Organic Forage Cultivation Systems

Life
Weed suppression is a crucial factor in sustainable agriculture, and optimizing plant mixtures can enhance weed control efficiency. This study evaluates the effects of different mixture ratios of common vetch (Vicia sativa L.) and annual ryegrass (Lolium
Hüseyin Çağlar, Serap Kizil Aydemir, Koray Kaçan   +2 more
doaj   +1 more source