Results 301 to 310 of about 1,259,951 (349)

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

CMD-type resistance and cassava genotypes symptomatic scoring determined using a scale of 1–5.

Bulelani L. Sizani (21485746), Keelan Krinsky (21485749), Oboikanyo A. Mokoka (21485752), Marie E. C. Rey (15852605)   +3 more
openalex   +1 more source

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

GENOTYPE x ENVIRONMENT INTERACTIONS (1)

, 1972
openaire   +1 more source

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Natural history of chronic hepatitis C: Genotype 1 versus genotype 6

Journal of Hepatology, 2010
Data on the natural history of chronic hepatitis C virus (HCV) genotype 6 is lacking.We compared the natural history of 138 HCV genotype 1 patients (median age: 50) with 78 HCV genotype 6 patients (median age: 46.5). Baseline demographic data including gender, route of transmission, liver biochemistry, HCV RNA levels, and serial alanine ...
Ching-Lung Lai, James Fung, Ivan Fan Ngai Hung   +2 more
exaly   +5 more sources

Hepatitis C genotype 1

Current Opinion in Infectious Diseases, 2014
To assess advances in the treatment of genotype 1 (G1 hepatitis C virus), in particular, the development of new interferon (and ribavirin)-free treatment regimes.The treatment of hepatitis C has advanced rapidly over the last 24 months. Newer interferon-containing regimes have been developed with improved tolerability, and interferon-free regimes with ...
Graham R, Foster, Sampath, De Silva
openaire   +2 more sources

Genotypic subtypes of HIV-1 in Cameroon

AIDS, 1994
The only two HIV-1 strains (ANT70 and MVP5180) reported to date from Cameroon are members of the outlier clade (group O). In this study, we assessed the prevalence of group O viruses and other HIV-1 subtypes in Cameroon.A phylogenetic analysis of 18 HIV-1 strains isolated from seropositive individuals from Yaoundé and Douala, Cameroon.A 900 base-pair ...
Nkengasong, J. N., Janssens, W., Heyndrickx, L., Fransen, K., Ndumbe, P. M., Motte, J., Leonaers, A., Ngolle, M., Ayuk, J., Piot, P., van der Groen, G.   +10 more
openaire   +2 more sources

GBV-C/HGV genotypes: Proposed nomenclature for genotypes 1-5

Journal of Medical Virology, 2000
The GB virus-C and hepatitis G virus (GBV-C/HGV) are variants of the same flavivirus. This proposal attempts to clarify the conflicting nomenclature for GBV-C/HGV genotypes. The first three genotypes described were genotype 1 (West Africa); genotype 2 (US/Europe) and genotype 3 (Asia).
T J, Tucker, H E, Smuts
openaire   +2 more sources

Hepatitis C virus genotype 4: Genotype 1's little brother

Journal of Viral Hepatitis, 2016
SummaryTreatment for hepatitis C virus genotype 4 infection has undergone a major advance over the past 5 years with the emergence of direct‐acting antiviral agents. Previously, genotype 4 treatment had been limited to the combination of pegylated interferon and ribavirin, with low rates of sustained virological response. The combinations of new direct‐
J, Llaneras, M, Riveiro-Barciela, M, Buti, R, Esteban   +3 more
openaire   +2 more sources