Predicting the effectiveness of hepatitis C virus neutralizing antibodies by bioinformatic analysis of conserved epitope residues using public sequence data [PDF]
, 2018 Hepatitis C virus (HCV) is a global health issue. Although direct-acting antivirals are available to target HCV, there is currently no vaccine. The diversity of the virus is a major obstacle to HCV vaccine development. One approach toward a vaccine is to
Cowton, Vanessa M. +3 more
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Alpha‐1‐antitrypsin genotyping with mouthwash specimens [PDF]
European Respiratory Journal, 2001 α1‐antitrypsin (α1‐AT) deficiency is diagnosed as a two-stage procedure (concentration and phenotype). However the latter does not provide clues to the presence of null genes without family studies and obtaining blood from patients at a distance often proves difficult.
R A, Stockley, E J, Campbell
openaire +2 more sources
Faldaprevir and Deleobuvir for HCV Genotype 1 Infection [PDF]
New England Journal of Medicine, 2013 Interferon-free regimens would be a major advance in the treatment of patients with chronic hepatitis C virus (HCV) infection.In this phase 2b, randomized, open-label trial of faldaprevir (a protease inhibitor) and deleobuvir (a nonnucleoside polymerase inhibitor), we randomly assigned 362 previously untreated patients with HCV genotype 1 infection to ...
Zeuzem, Stefan +16 more
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Baseline anti-NS4a antibodies in combination with on-treatment quantitative HCV-RNA reliably identifies nonresponders to pegylated interferon-ribavirin combination therapy after 4 weeks of treatment [PDF]
, 2010 Background Early detection of nonresponders to hepatitis C therapy limits unnecessary exposure to treatment and its side-effects. A recent algorithm combining baseline anti-NS4a antibodies and on-treatment quantitative PCR identified nonresponders to a ...
de Knegt, Robert J +8 more
core +1 more source
Comparison of Structural Architecture of HCV NS3 Genotype 1 versus Pakistani Genotype 3a [PDF]
BioMed Research International, 2014 This study described the structural characterization of Pakistani HCV NS3 GT3a in parallel with genotypes 1a and 1b NS3. We investigated the role of amino acids and their interaction patterns in different HCV genotypes by crystallographic modeling.
Kaneez Fatima +4 more
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Antiviral therapy in chronic hepatitis C (G1) in Russia: cost and effectiveness
Журнал инфектологии, 2015 Genotype 1 HCV treatment in Russia assume as bitherapy (pegylated interferon – PG plus ribavirin – RBV) as three therapy based on HCV protease inhibitor such as telaprevir (TLV), boceprevir (BCV) or simeprevir (SMV) plus PG/RBV.
A. V. Rudakova +3 more
doaj +1 more source
Early Experience of Sofosbuvir based Combination Therapy in “Real-Life” Cohort with Chronic Hepatitis-C Infection [PDF]
Journal of Clinical and Diagnostic Research, 2017 Introduction: There is scarcity of data in literature regarding the treatment response with Sofosbuvir (SOF) based therapy in Indian patients with chronic Hepatitis-C Virus (HCV) infection.
Rajiv Mehta +4 more
doaj +1 more source
Журнал инфектологии, 2018 Interferon-free therapy for genotype 1 hepatitis C is highly effective at any severity of liver fibrosis. The purpose of work was to assess cost-effectiveness and the budget impact of paritaprevir/ombitasvir/dasabuvir/ ritonavir (PTV/OBV/DSV/r ...
A. V. Rudakova +4 more
doaj +1 more source
Cross reactive cellular immune response to HCV genotype 1 and 4 antigens among genotype 4 exposed subjects. [PDF]
PLoS ONE, 2014 BACKGROUND: Hepatitis C Virus (HCV) infection is a global health burden particularly in Egypt, where HCV genotype 4a (GT-4a) predominates. The prevention and control of HCV infection will remain a challenge until the development of an effective vaccine ...
Iman F Galal +8 more
doaj +1 more source
, 2014 AIM: To investigate the predictability of interleukin-28B single nucleotide polymorphism rs12979860 with respect to sustained virological response (SVR) in chronically hepatitis C virus (HCV) genotype-1 patients treated with a protease-inhibitor and ...
Amanzada, Ahmad +3 more
core +1 more source