Results 251 to 260 of about 263,661 (293)

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

ProSiteHunter: A Unified Framework for Sequence‐Based Prediction of Protein‐Nucleic Acid and Protein‐Protein Binding Sites

Advanced Science, EarlyView.
This study proposed a unified sequence‐based framework for protein binding site prediction, which adopted a tri‐track semantic multi‐source feature fusion strategy to effectively capture diverse macromolecular interaction sites and further improved the accuracy of antibody‐antigen interaction prediction.
Dongliang Hou, Qihang Zhen, Zexin Lv, Xinyue Cui, Suhui Wang, Minghua Hou, Zhan Zhou, Xiaogen Zhou, Guijun Zhang   +8 more
wiley   +1 more source

Changing Patterns of HCV Genotype Distribution in a Migration-Affected Region of Turkey: A Retrospective Hospital-Based Study (2014-2021). [PDF]

Viruses
Altintop YA, Saatçi E.
europepmc   +1 more source

Steatohepatitis is associated with diabetes and fibrosis in genotype 1b HCV‐related chronic liver disease

Journal of Viral Hepatitis, 2007
Summary.  Liver steatosis, diabetes mellitus and hepatitis C virus (HCV) genotype have been implicated in liver fibrosis in HCV‐related chronic active hepatitis (CAH). The aim of this study was to evaluate whether steatosis and diabetes were associated with more severe liver fibrosis in patients with genotype 1b HCV‐related CAH.
MASARONE, MARIO, La Mura V, Bruno S, Gaeta GB, Vecchione R, Carrino F, Moschella F, Torella R, PERSICO, Marcello   +8 more
core   +8 more sources

[beta-Interferon therapy of chronic hepatitis HCV+, 1b genotype].

Recenti progressi in medicina, 1998
Various papers reported that chronic viral hepatitis is the principal cause of chronic liver disease, as cirrhosis and hepatocarcinoma. Interferon is the only agent known to have a beneficial effect in chronic hepatitis. The response rate has been less than 10 percent in patients with genotype 1b, but in patients with genotype 2 or 3 it has been ...
VEZZOLI, MONIA, MAZZUCCHELLI, IOLANDA, GRITTI, DONATELLA, Girola, S, Fossati, G, Mazzone, A.   +5 more
openaire   +2 more sources

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Hepatitis C flare due to superinfection by genotype 4 in an HCV genotype 1b chronic carrier

European Journal of Gastroenterology & Hepatology, 2002
We report here on a patient affected by chronic hepatitis C who developed acute hepatitis C virus (HCV) superinfection with replacement of genotype 1b by genotype 4. The history revealed no risk factors for a new exposure to HCV, with the exception of colonoscopy with mucosal biopsy performed about 3 months before. This report underlines the absence of
ACCAPEZZATO, DANIELE, Francesca Fravolini, Marco Antonio Casciaro, PAROLI, Marino   +3 more
openaire   +2 more sources

A genotype 2b NS5B polymerase with novel substitutions supports replication of a chimeric HCV 1b:2b replicon containing a genotype 1b NS3-5A background

Antiviral Research, 2006
HCV diversity suggests that evaluation of HCV inhibitors for broad genotypic efficacy is warranted. The replicon system enables cell-culture compound efficacy evaluation against an active replication complex, and a functional replicon dependent upon a genotype 2b polymerase would augment existing cell-culture efficacy studies that are presently limited
Donald J, Graham, Mark, Stahlhut, Osvaldo, Flores, David B, Olsen, Daria J, Hazuda, Robert L, Lafemina, Steven W, Ludmerer   +6 more
openaire   +2 more sources

Replacement of Hepatitis C Virus Genotype 1b by Genotype 2 Over a 10-year Period in Venezuela

Journal of Clinical Gastroenterology, 2007
Changes in hepatitis C virus (HCV) genotype distribution with time have been reported in several countries.To explore eventual changes in HCV genotype distribution in Venezuela over a 10 years period.HCV genotype was determined by direct sequencing of the 5' noncoding region, in 236 isolates circulating in patients treated during years 2005 to 2006 ...
Flor H, Pujol, Carmen L, Loureiro
openaire   +2 more sources

Development of cell culture infectious clones for hepatitis C virus genotype 1b and transcription analysis of 1b-infected hepatoma cells

Antiviral Research, 2021
Globally, hepatitis C virus (HCV) genotype 1b is the most prevalent, and its infection has been found to associate with a higher risk of hepatocellular carcinoma (HCC) than other genotype viruses. However, an efficient infectious HCV genotype 1b culture system is unavailable, which has largely hampered the study of this important genotype virus.
Jinqian Li, Qing Zhou, Liang Rong, Dade Rong, Yang Yang, Jiawei Hao, Zhenzhen Zhang, Ling Ma, Guirong Rao, Yuanping Zhou, Fei Xiao, Chengyao Li, Haihe Wang, Yi-Ping Li   +13 more
openaire   +2 more sources

Hepatitis C Virus Genotypes 1a and 1b Mixed Infections

Vox Sanguinis, 1997
AbstractIn response to Poljak and Seme's letter, we would like to point out that the manuscript published in another journal [1], although based on the same study population, was only meant to discuss the results of Pawlotsky et al. [2], who claimed that hepatitis C virus (HCV) genotype 3a was the predominant type among injecting drug users (IDUs) in ...
V. Soriano, R. Bravo, J. García‐Samaniego   +2 more
openaire   +1 more source