Results 301 to 310 of about 1,197,745 (340)

Determinants of Infection Outcome in HCV-Genotype 4

Viral Immunology, 2017
Hepatitis C virus (HCV) infection represents a worldwide health problem and has been for long an attractive point of research due to diversity among different genotypes regarding unique geographical distribution and diverse treatment outcome. HCV is considered a major cause of chronic liver disease and cirrhosis, which leads to liver failure and ...
Rania A, Zayed, Dalia, Omran, Abeer A, Zayed, Lobna O, Elmessery   +3 more
openaire   +2 more sources

Hepatitis C virus genotype 4: Genotype 1's little brother

Journal of Viral Hepatitis, 2016
SummaryTreatment for hepatitis C virus genotype 4 infection has undergone a major advance over the past 5 years with the emergence of direct‐acting antiviral agents. Previously, genotype 4 treatment had been limited to the combination of pegylated interferon and ribavirin, with low rates of sustained virological response. The combinations of new direct‐
J, Llaneras, M, Riveiro-Barciela, M, Buti, R, Esteban   +3 more
openaire   +2 more sources

Optimal Management of HCV Genotype 4

Current Hepatology Reports, 2014
The optimal treatment for HCV genotype 4 (HCV-G4)-infected patients is still evolving. Pegylated interferon (PEG)-ribavirin (RBV) therapy was the standard of care but provides moderate response rates and adverse events. Sofosbuvir (SOF) and simeprevir (SIM) allow for shorter duration and higher cure rates when added to PEG-RBV.
Wael Abdel-Razek, Imam Waked
openaire   +1 more source

Distribution of hepatitis C genotypes in Uttar Pradesh, India; rare genotype 4 detected

Journal of Medical Virology, 2018
AimThe worldwide prevalence of hepatitis C virus infection (HCV) is nearly 150 to 170 million cases. The prevalence of HCV infection in India is estimated to be around 1%. In India HCV genotype (GT)3 is the predominant GT followed by GT1. Our study aims to establish the prevalent GTs/subtypes of HCV circulating in Uttar Pradesh, North India, as ...
Shantanu Prakash, Suruchi Shukla, Vangala Ramakrishna, Amita Jain   +3 more
openaire   +2 more sources

Molecular heterogeneity and new subtypes of HCV genotype 4

Research in Virology, 1998
The subtype distribution of HCV genotype 4 was studied in two different African countries, Egypt and Tanzania. The HCV isolates were obtained from epidemiological studies involving, respectively, 135 hepatopatic patients and 1043 pregnant women and outpatients.
M, Rapicetta, C, Argentini, S, Dettori, E, Spada, G, Pellizzer, C, Gandin   +5 more
openaire   +2 more sources

Hepatitis C flare due to superinfection by genotype 4 in an HCV genotype 1b chronic carrier

European Journal of Gastroenterology & Hepatology, 2002
We report here on a patient affected by chronic hepatitis C who developed acute hepatitis C virus (HCV) superinfection with replacement of genotype 1b by genotype 4. The history revealed no risk factors for a new exposure to HCV, with the exception of colonoscopy with mucosal biopsy performed about 3 months before. This report underlines the absence of
ACCAPEZZATO, DANIELE, Francesca Fravolini, Marco Antonio Casciaro, PAROLI, Marino   +3 more
openaire   +2 more sources

Distribution of Hepatitis C Virus Genotypes in Kayseri Region, in Turkey: Unexpected Rate of Genotype 4

Clinical Laboratory, 2013
Hepatitis C virus (HCV) is an important cause of chronic liver disease. There are six genotypes and more than 80 subtypes of HCV. The aim of this study was to investigate the distribution of HCV genotypes in Middle Anatolia in Turkey, and the association of HCV genotypes with pre-treatment HCV RNA viral load, serum transaminase levels, and ...
Karaman, Hatice, Sariguzel, FATMA, Karaman, Ahmet, Karakukcu, ÇİĞDEM, Kayman, Tuba   +4 more
openaire   +3 more sources

Toll‐like receptor‐4 genotype in children with respiratory infections

Allergy, 2004
We aimed to investigate the possiblerole of TLR4 in susceptibility to pneu-monia in Italian ...
Badolato R., Fontana S., Barcella L., Moratto D., D'Ippolito C., Crovella S., Notarangelo L. D., Duse M.   +7 more
openaire   +6 more sources

Treatment of Chronic HCV Genotype 4 Infection

Current Hepatitis Reports, 2012
Hepatitis C virus genotype 4 (HCV4) is the most common type of hepatitis C virus (HCV) in the Middle East and Africa, in particular Egypt. Treatment with pegylated interferon and Ribavirin is still the standard regimen of care with overall response ranging between 50 and 60 %.
G. Esmat, M. Raziky, M. El-Kassas, M. Hassany, M. E. Gamil   +4 more
openaire   +1 more source

[Chronic C hepatitis genotype 4].

Medicina clinica, 2011
The hepatitis C virus (HCV) is one of the most important causal agents of liver disease. Genotype 4 is responsible for 20% of chronic hepatitis and in several countries of the Mediterranean area it has been reported that the prevalence is increasing.
Rosario, González-Casas, María, Trapero-Marugán, Ricardo, Moreno-Otero   +2 more
openaire   +1 more source