Results 221 to 230 of about 6,439,956 (330)

Detection of the intergenic region III and multigene family 505 9R and 10R-V variant of African swine fever virus genotype II on pig farms in South Korea. [PDF]

Arch Virol
Cho KH, Kim DY, Hong SK, Yoo DS, Kang HE, Kim YH.   +5 more
europepmc   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Exploiting Viral DNA Genomes to Explore the Dispersal History of African Swine Fever Genotype II Lineages in Europe. [PDF]

Genome Biol Evol
Gámbaro F, Goatley LC, Foster TJ, Tennakoon C, Freimanis GL, Van Borm S, Masiulis M, Bušauskas P, Netherton CL, Dellicour S.   +9 more
europepmc   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

Deletion of B125R increases protection induced by a genotype II African swine fever vaccine candidate. [PDF]

NPJ Vaccines
Rathakrishnan A, Reis AL, Moffat K, Goatley L, Viaplana E, Mancera JC, Urniza A, Dixon LK.   +7 more
europepmc   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

Detection of African Swine Fever Virus Genotype II in West Africa (2020) and Its Co-Circulation With Endemic Genotype I: Implications for Pig Production. [PDF]

Transbound Emerg Dis
Meki IK, Adedeji AJ, Ouoba LB, Koffi YM, Diakité A, Settypalli TBK, Habibata-Zerbo L, Kouakou KV, Diakité MA, Masembe C, Sidi M, Douyeri TO, Dembelé F, Luka HE, Hamidou-Ouandaogo S, Dembelé C, Weka R, Bazimo G, Dakouo M, Olubade TA, Guitti-Kindo M, Traoré C, Gamra O, Guigma D, Sidibé CAK, Hambolu DA, Adama DD, Maïga BMDA, Ogunleye MA, Toluhi A, Maurice N, Couacy-Hymann E, Luka PD, Cattoli G, Lamien CE.   +34 more
europepmc   +1 more source

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

Epidemiological Characteristics of the African Swine Fever Genotype II Epidemic in Domestic Pigs in Lombardy (Northern Italy) in 2023 and 2024. [PDF]

Viruses
Bellini S, Salvato S, Bernardis M, Chiari M, Martinello F, Galimberti L, Maggiano V, Feliziani F, Farioli M, Alborali GL.   +9 more
europepmc   +1 more source