Results 111 to 120 of about 214,572 (265)

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Genotypic data for the IND298 panel

, 2022
GBS genotypic data for a Indian panel with 298 common wheat ...
He, Xinyao, Singh, Gyanendra P., Joshi, Arun K., Singh, Pawan   +3 more
core   +1 more source

Selection of genotypic drug resistance tests.

, 2013
Selection of genotypic drug resistance tests.
Jürg Böni (36157), Thomas Klimkait (178911), Enos Bernasconi (174329), Alexandra Calmy (36005), Heiner C. Bucher (134728), Dunja Nicca (336117), Viktor von Wyl (146506), Sabine Yerly (82534), Matthias Cavassini (146654), Hansjakob Furrer (93994), Tracy R. Glass (134725), Vincent Aubert (297526), Huldrych F. Günthard (173082)   +12 more
core   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Nougué et al 2015 Individual Genotypic data

, 2015
Microsatellite genotypic individual data for the populations used in the ...
Lenormand, Thomas, Roula Zahab (3276405), Christoph R. Haag (192439), Zahab, Roula, Thomas Lenormand (58424), Nougué, Odrade, Ségard, Adeline, Luis-Miguel Chevin (249731), Chevin, Luis-Miguel, Rode, Nicolas O., Odrade Nougué (3193902), Nicolas O. Rode (3276411), Haag, Christoph R., Adeline Ségard (3276408)   +13 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Egg-laying ChickenGTEx resource deciphers context-specific regulatory effects on fertility traits

Nature Communications
Characterization of the genetic and molecular architecture underlying egg production traits in chickens is essential for improving the rate of genetic gain through intensive artificial selection.
Di Zhu, Kai Shi, The ChickenGTEx Consortium, Chong Li, Yidan Yan, Houcheng Li, Zhonghao Bai, Lizhi Tan, Dailu Guan, Yiqiang Zhao, Yuzhe Wang, Baoliang Fan, Ziqin Jiang, Zhenqiang Xu, Chungang Feng, Lingzhao Fang, Xiaoxiang Hu   +16 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source