Results 1 to 10 of about 14,948 (117)

The impact of the RTS,S malaria vaccine on uncomplicated malaria: evidence from the phase IV study districts, Upper East Region, Ghana, 2020–2022 [PDF]

Malaria Journal
Background The RTS,S malaria vaccine has been prequalified for use in endemic settings prioritizing areas with moderate to high disease transmission. The impact of a vaccine at the population level may differ from observations during clinical trial due ...
Michael Rockson Adjei, Rafiq Okine, Peter Ofori Tweneboah, Janet Vanessa Baafi, Nana Akua Afriyie, Emmanuel Akwoulo Agyigewe Teviu, Josephat Ana-Imwine Nyuzaghl, Emmanuel Kofi Dzotsi, Sally-Ann Ohene, Martin Peter Grobusch   +9 more
doaj   +2 more sources

The role of immune-inflammatory markers in children with complicated and uncomplicated malaria in Enugu, Nigeria [PDF]

BMC Immunology
Background There is currently insufficient data regarding immune parameters and relationship with severity of malaria infection in Enugu, Nigeria where the economic and social costs of the disease and its management are extremely high.
Angela Ogechukwu Ugwu, Rebecca Chinyelu Chukwuanukwu, Friday Alfred Ehiaghe, Emmanuel Onyebuchi Ugwu   +3 more
doaj   +2 more sources

Transforming Growth Factor-β Concerning Malarial Infection and Severity: A Systematic Review and Meta-Analysis

Tropical Medicine and Infectious Disease, 2022
Transforming growth factor-β (TGF-β) is important in the pathophysiology of malaria, but its role in acute and severe malaria is largely unknown. As a result, this study used a meta-analysis approach to investigate the difference in TGF-β levels between ...
Kwuntida Uthaisar Kotepui, Pattamaporn Kwankaew, Frederick Ramirez Masangkay, Aongart Mahittikorn, Manas Kotepui   +4 more
doaj   +1 more source

C-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis

Scientific Reports, 2021
This study investigated whether C-reactive protein (CRP) can be used as a marker for the early detection and monitoring of malaria severity. Potentially relevant studies were searched in Medline (PubMed), Scopus, and Web of Science.
Polrat Wilairatana, Praphassorn Mahannop, Thanita Tussato, I-mee Hayeedoloh, Rachasak Boonhok, Wiyada Kwanhian Klangbud, Wanida Mala, Kwuntida Uthaisar Kotepui, Manas Kotepui   +8 more
doaj   +1 more source

Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study. [PDF]

PLoS ONE, 2018
BACKGROUND:Evidence for association between sickle cell and alpha thalassemia trait and severe malaria is compelling. However, for these polymorphisms associations with uncomplicated malaria, and for G6PD deficiency associations with uncomplicated and ...
Arthur Mpimbaza, Andrew Walakira, Grace Ndeezi, Anne Katahoire, Charles Karamagi, Samuel L Nsobya, Stephen Tukwasibwe, Victor Asua, Philip J Rosenthal   +8 more
doaj   +1 more source

Increased interferon-γ levels and risk of severe malaria: a meta-analysis

Scientific Reports, 2022
Interferon (IFN)-γ contributes to the pathogenesis of severe malaria; however, its mechanism remains unclear. Herein, differences in IFN-γ levels between patients with severe and uncomplicated malaria were evaluated using qualitative and quantitative ...
Aongart Mahittikorn, Wanida Mala, Frederick Ramirez Masangkay, Kwuntida Uthaisar Kotepui, Polrat Wilairatana, Manas Kotepui   +5 more
doaj   +1 more source

Procalcitonin levels in children affected by severe malaria compared to those with uncomplicated malaria in the absence of bacterial infection: a cross-sectional study

Tropical Diseases, Travel Medicine and Vaccines, 2022
Background Procalcitonin is an inflammatory marker strongly associated with the presence of bacterial infection. It has been considered raised in severe malaria infection as opposed to uncomplicated malaria.
Jean-Claude Katte, Kiya Penanje, Batakeh B. Agoons, Eric Noel Djahmeni, Sharon Mbacham-Ngwafor, Vicky Jocelyne Ama Moor, Paul Koki, Wilfred Mbacham   +7 more
doaj   +1 more source

Elevation of serum interleukin-1β levels as a potential indicator for malarial infection and severe malaria: a meta-analysis

Malaria Journal, 2022
Background Interleukin (IL)-1β is a proinflammatory cytokine that has a role in disease-related inflammation, including malaria. However, reports on the effect of IL-1β on malaria severity are inconsistent. Therefore, meta-analyses to compare differences
Aongart Mahittikorn, Pattamaporn Kwankaew, Pongruj Rattaprasert, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay, Manas Kotepui   +5 more
doaj   +1 more source

Prescription patterns and compliance with World Health Organization recommendations for the management of uncomplicated and severe malaria: A prospective, real-world study in sub-Saharan Africa

Malaria Journal, 2023
Background This study aimed to evaluate the gap between guidelines and local clinical practice for diagnosis and treatment of uncomplicated and severe malaria, the patient characteristics, diagnostic approach, treatment, and compliance to standard ...
Vito Baraka, Abel Nhama, Pedro Aide, Quique Bassat, Agatha David, Samwel Gesase, Jonathan Gwasupika, Sebastian Hachizovu, Geofrey Makenga, Christian Ruchaho Ntizimira, Orikomaba Obunge, Kitoto Antoinette Tshefu, Marc Cousin, Nekoye Otsyula, Rashidkhan Pathan, Céline Risterucci, Guoqin Su, Christine Manyando   +17 more
doaj   +1 more source

Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria

Malaria Journal, 2022
Background Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria.
Leo Leonardo, Enny Kenangalem, Jeanne R. Poespoprodjo, Rintis Noviyanti, Ric N. Price, Nicholas M. Anstey, Gabriela Minigo, Steven Kho   +7 more
doaj   +1 more source