Results 101 to 110 of about 456,399 (317)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Pathogens, 2020 Swine act as both maintenance and incidental hosts of pathogenic Leptospira spp. Here, a serological test was performed on 131,660 pig sera collected between 2002 and 2017 from 4715 farms in Northern Italy.
Cristina Bertasio +5 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Emerging Microbes and Infections, 2016 Fusarium is a rapidly emerging, multidrug-resistant genus of fungal opportunists that was first identified in 1958 and is presently recognized in numerous cases of fusariosis each year.
Abdullah MS Al-Hatmi +4 more
doaj +1 more source
Pathogens, 2020 Sand flies (Diptera: Psychodidae: Phlebotominae) are blood-feeding insects that transmit the protozoan parasites Leishmania spp. and various arthropod-borne (arbo) viruses.
Edwin Kniha +15 more
doaj +1 more source
Using the R Package crlmm for Genotyping and Copy Number Estimation [PDF]
Genotyping platforms such as Affymetrix can be used to assess genotype-phenotype as well as copy number-phenotype associations at millions of markers.
Rafael A. Irizarry +4 more
core
Genotyping primers and genotyping conditions.
, 2022 Genotyping primers and genotyping conditions.
Elelbin A. Ortiz (8655285) +7 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Genotyping-by-Sequencing - Comparison to SNP chips and whole genome sequencing
, 2015 Genotyping-by-sequencing (GBS) has the potential to be a cost effective, reproducible and high-throughput SNP genotyping method. Although we have been investigating GBS in a number of livestock and aquaculture species, we have concentrated largely on ...
Rudiger Brauning (47247) +4 more
core +1 more source
BirdsCoxiella burnetii is a highly infectious zoonotic pathogenic bacterium that has a major economic impact in the livestock industry throughout the world and causes unpredictable outbreaks in humans worldwide.
Filipa Loureiro +10 more
doaj +1 more source