Results 81 to 90 of about 612,806 (292)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Biological and Molecular Characterization of Five Trypanosoma cruzi (Chagas, 1909) (Kinetoplastida, Trypanosomatidae) Isolates from the State of Hidalgo, Mexico

Tropical Medicine and Infectious Disease
Trypanosoma cruzi, the causal agent of Chagas disease, exhibits great genetic diversity, which has been related to its biological properties. However, these are poorly known in strains from the endemic area of Hidalgo. To assess the parasite’s virulence,
Yessenia Montes-Vergara, Alberto Antonio-Campos, José Miguel Padilla-Valdez, Erick Abraham Contreras-López, Julio Cesar Noguez-García, Nancy Rivas, Ricardo Alejandre-Aguilar   +6 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Advances in deep learning and MRI co-assisted genotyping of brain gliomas

陆军军医大学学报
The genotypic status of gliomas is a critical indicator for assessing patient prognosis and survival duration, with its genetic classification holding significant clinical value.
CUI Shaoguo, CHEN Junshan
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Discrimination of Clinical and Food-Derived Candida Strains Using Biotyping and Molecular Typing Approaches

Pathogens
Identification and differentiation of Candida spp. yeasts, especially clinically relevant isolates, is of high importance with respect to their origin, pathogenic potential, colonization pattern, and resistance to antimycotics. Currently, numerous typing
Katarzyna Rajkowska, Anna Otlewska, Dorota Simińska   +2 more
doaj   +1 more source

Association of Superoxide Dismutase 2 (SOD2) Genotype with Gray Matter Volume Shrinkage in Chronic Alcohol Users: Replication and Further Evaluation of an Addiction Gene Panel. [PDF]

, 2016
BackgroundReduction in brain volume, especially gray matter volume, has been shown to be one of the many deleterious effects of prolonged alcohol consumption. High variance in the degree of gray matter tissue shrinkage among alcohol-dependent individuals
Gitik, Miri, Goldman, David, Hodgkinson, Colin A, Meyerhoff, Dieter J, Shen, Pei-Hong, Srivastava, Vibhuti   +5 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Successful purification of DNA from PFGE agarose plugs for whole genome sequencing

Acta Biologica Slovenica
Whole-genome sequencing (WGS) has replaced Pulsed-field gel electrophoresis (PFGE)-based bacterial genotyping as the reference genotyping method. We investigated the suitability of purified genomic DNA extracted from PFGE agarose plugs stored in a ...
Katja Strašek Smrdel, Andraž Celar Šturm, Tina Triglav, Mateja Pirš   +3 more
doaj   +1 more source

Molecular Characterization and Genotyping Study of Food Poisoning Staphylococcus aureus, Isolated from Raw Milk and Milk Products in Al-Diwaniyah, Iraq

Journal of Pure and Applied Microbiology, 2018
Staphylococcus aureus still resembles one of the primary causes of food poisoning induced specifically by milk and its products. Recent studies from neighbor countries of Iraq showed the presence of this bacterium in the milk of cattle, sheep, and goat.
Hayfaa Jumaah Hasan Alhasnawi, Basima Jasim Mohammed, Zahira A. Al-Zuhairi   +2 more
doaj   +1 more source