Results 71 to 80 of about 612,806 (292)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
CGIAR Excellence in Breeding Platform - Plan of Work and Budget 2020 [PDF]
, 2020 At the end of 2019, all CGIAR centers had submitted improvement plans based on an EiB template and in close collaboration with EiB staff while – in a parallel process with breeding programs, funders and private sector representatives – a vision for ...
CGIAR Excellence in Breeding Platform
core
Genome Assembly Improvement and Mapping Convergently Evolved Skeletal Traits in Sticklebacks with Genotyping-by-Sequencing. [PDF]
, 2015 Marine populations of the threespine stickleback (Gasterosteus aculeatus) have repeatedly colonized and rapidly adapted to freshwater habitats, providing a powerful system to map the genetic architecture of evolved traits.
Glazer, Andrew M +4 more
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Methodological Issues in Multistage Genome-Wide Association Studies [PDF]
, 2009 Because of the high cost of commercial genotyping chip technologies, many investigations have used a two-stage design for genome-wide association studies, using part of the sample for an initial discovery of ``promising'' SNPs at a less stringent ...
Casey, Graham +5 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KASPTM genotyping technology and its use in genetic-breeding programs (a study of maize)
Plant Varieties Studying and Protection, 2017 Purpose. To review publications relating to the key point of the genotyping technology that is competitive allele-specific polymerase chain reaction (which is called now Kompetitive Allele Specific PCR, KASPTM) and its use in various genetic-breeding ...
Н. Е. Волкова +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Siberian Journal of Life Sciences and AgricultureMolecular genetic studies make it possible to determine the relationship between genetic factors and the incidence of diabetes in different parts of the world. Molecular genetic studies to determine HLA genotypes predisposing to the development of type 1
Naina A. Yusupova +6 more
doaj +1 more source
Assessing the genetic diversity of rice originating from Bangladesh, Assam and West Bengal [PDF]
, 2015 Acknowledgements This work was funded by BBSRC research project BB/J00336/1. FS and a part of the proportion of the cost of the Illumina genotyping was funded by a Beachell-Borlag International Fellowship.
Dasgupta, Tapash +11 more
core +2 more sources