Results 71 to 80 of about 456,399 (317)
Genotyping with TaqMAMA
Genomics, 2004 TaqMAMA combines the quantitative strengths of TaqMan with the allele-specific PCR of MAMA. In this article we develop TaqMAMA as a technique for screening human DNA samples for known genetic polymorphisms. In the first set of experiments, plasmids that model all types of genetic polymorphisms were used to understand the relationship between TaqMAMA ...Baohui, Li, Ibrahim, Kadura, Dong-Jing, Fu, David E, Watson +3 moreopenaire +2 more sourcesThe Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits [PDF]
, 2012 Genome-wide association studies have identified hundreds of loci for type 2 diabetes, coronary artery disease and myocardial infarction, as well as for related traits such as body mass index, glucose and insulin levels, lipid levels, and blood pressure ...Kang, HM, Boehnke, M., Kathleen Stirrups, Ding, J., Abecasis, Gonçalo R., Samani, NJ, Winckler Wendy, Sanna, Serena, Teslovich, T.M., McCarthy, Mark I, Teslovich, Tanya M., Pfeufer, Arne, Kathiresan, S., Morris Andrew P., Potter, S, Wheeler, E., Boehnke, M, Ruth J. F. Loos, Sanna, S, Jackson, Anne U., Melissa Parkin (145722), Joel N Hirschhorn, Randall, Joshua C, Sanna, S., Palmer, C.D., Hirschhorn, Joel, Heid Iris M., Wendy Winckler (145732), Chines Peter S., S. Potter (6187), Palmer, CD, Winckler, Wendy, Barroso, Inês, S. Sanna (7609256), Erdmann Jeanette, Loos, Ruth J F, N. Robertson (61307), D. Altshuler (7606010), Randall, J.C., Frayling, Timothy M., Fuchsberger Christian, Heid, I.M., C. D. Palmer (7626644), Altshuler, D., E. Wheeler (4607599), Speliotes, E.K., N. W. Rayner (7626794), Newton-Cheh Christopher, Joshua C. Randall (145712), Munroe, PB, Kilpeläinen, T.O., Cecilia M Lindgren, Stirrups, K., Voight, Benjamin F., Mulas Antonella, Potter, Simon, Parkin, M, Chines, P.S., Serena Sanna (145737), Cameron D Palmer, Gonçalo R Abecasis, Mark I. Mccarthy, Francesco Cucca (145742), J. N. Hirschhorn (7609139), Pfeufer Arne, Johnson, T, Michael Boehnke (145750), Sidore, Carlo, Johnson, T., T. M. Teslovich (7683197), Eleanor Wheeler, R. Saxena (7608878), I. Prokopenko (7608875), Antonella Mulas, Maguire, J., Tuomas O. Kilpeläinen (145704), Peter S Chines, T. O. Kilpeläinen (7683194), McCarthy, MI, C. M. Lindgren (7611374), N. William Rayner (21703), Benjamin F. Voight, Voight Benjamin F., McCarthy Mark I., Li, Y.M., Peter S. Chines, Saxena, R, A. Pfeufer (7670843), Morris, Andrew, Antonella Mulas (145739), Hirschhorn Joel N., Gonçalo R. Abecasis (36598), Prokopenko, Inga, Morris, AP, Teslovich, Tanya M, I. M. Heid (7611266), Schunkert, H, Carlo Sidore (145691), Kilpeläinen, TO, P. S. Chines (7626599), Robertson, N, Frayling Timothy M., Deloukas Panos, Cucca, F., Abecasis, G.R., N. J. Samani (7591811), Noël P. Burtt, Kang, H.M., Schunkert, H., Morris, Andrew P, Chines, Peter S, B. F. Voight (7605833), P. B. Munroe (7602386), Neil Robertson, Erdmann, Jeanette, Maguire, Jared, Chines, PS, Loos, Ruth J. F., Inga Prokopenko (43252), Li, YM, Parkin Melissa, Erdmann, J., McCarthy, Mark, Loos, RJF, Potter Simon, Munroe, Patricia B., Richa Saxena (28290), Yanming Li (145698), Andrew P Morris, Jackson, A.U., Robertson, N., Et Al, Oskari Kilpeläinen, Tuomas, Noël P. Burtt (145695), E. K. Speliotes (7611380), Nagaraja, Ramaiah, Iris M Heid, Winckler, W, Sanna Serena, Rayner, N.W., Deloukas, P., Fuchsberger, Christian, Erdmann, J, S. Kathiresan (7606013), Toby Johnson, Joel N. Hirschhorn, Iris M. Heid, Neil Robertson (25148), Tanya M. Teslovich (145718), F. Cucca (7683212), Frayling, TM, W. Winckler (7683209), Toby Johnson (43283), Jackson Anne U., Hyun Min Kang, McCarthy, M.I., Ruth J F Loos, Morris, Andrew P., Munroe, P.B., J. Ding (2126038), Parkin, M., Boehnke Michael, N William Rayner, M. Boehnke (7605344), David Altshuler, Burtt, Noël P., Deloukas, Panos, Jackson, Anne U, Burtt, NP, Melissa Parkin, Prokopenko Inga, Nicole Soranzo Elizabeth K. Speliotes, Newton-Cheh, C, A. Mulas (7626920), Abecasis, GR, Jared Maguire (145720), Iris M. Heid (87553), Speliotes, EK, Carlo Sidore, Benjamin F. Voight (145685), Kilpelaeinen, TO, Cucca, Francesco, T. Johnson (7602368), Mark I McCarthy, Li Yanming, Robertson Neil, Hirschhorn, Joel N, Ding Jun, Panos Deloukas (21564), David Altshuler (27754), Maguire, J, Sidore, C., Soranzo Nicole, Ding, J, Yanming Li, Fuchsberger, C., Andrew P. Morris, Kang, Hyun Min, Burtt, Noël P, Wheeler, Eleanor, Joel N. Hirschhorn (131545), Kilpeläinen, Tuomas O., Anne U Jackson, Altshuler, David, Nagaraja, R, Palmer Cameron D., Sidore, C, Benjamin F Voight, Panos Deloukas, Peter S. Chines (145692), Inês Barroso (2144), H. M. Kang (7626701), Timothy M. Frayling, Munroe, Patricia B, Heid, Iris M., Lindgren, Cecilia M., Deloukas, P, Jackson, AU, Citable Link, Jeanette Erdmann (44256), Citation Voight, Wendy Winckler, Nagaraja, R., Serena Sanna, Y. Li (696089), Speliotes, Elizabeth K, Gonçalo R. Abecasis, Samani, Nilesh J., Robertson, Neil, Ruth J. F. Loos (110224), Newton Cheh, C, Lindgren, Cecilia, Wheeler, E, Voight, Benjamin F, Arne Pfeufer, Stirrups Kathleen, G. R. Abecasis (7602524), Newton-Cheh, Christopher, Francesco Cucca, Soranzo, N, Nilesh J. Samani (60118), Speliotes, Elizabeth K., Jeanette Erdmann, Schunkert Heribert, Simon Potter (145724), Altshuler David, Hyun Min Kang (145687), Heid, IM, Fuchsberger, C, Mark I. McCarthy (145748), Tuomas O. Kilpeläinen, Newton-Cheh, C., A. U. Jackson (7609325), Voight, BF, R. J. Loos (7608845), Inga Prokopenko, Lindgren, Cecilia M, Joshua C Randall, Chines, Peter S., Ramaiah Nagaraja, Burtt, N.P., Jun Ding (80820), Barroso, I., Timothy M Frayling, Andrew P. Morris (145709), Pfeufer, A., Heid, Iris M, Ding, Jun, Rayner N. William, Samani, N.J., Kathiresan, S, Speliotes Elizabeth K., Altshuler, D, I. Barroso (7609532), Palmer, Cameron D, Patricia B Munroe, Ramaiah Nagaraja (2394), Pfeufer, A, Soranzo, N., Boehnke, Michael, Burtt Noël P., Arne Pfeufer (76634), Eleanor Wheeler (28941), Sekar Kathiresan (60585), Parkin, Melissa, Sidore Carlo, Cecilia M. Lindgren (145706), Maguire Jared, C. Newton-Cheh (7602563), Patricia B. Munroe (145744), H. Schunkert (7603670), Rayner, N William, Randall, JC, Saxena Richa, McCarthy, Mark I., Saxena, Richa, Frayling, Timothy M, Patricia B. Munroe, Li, Y, Abecasis, Gonçalo R, Winckler, W., Nilesh J. Samani, Heribert Schunkert (44257), Kang Hyun Min, Prokopenko, I, Li, Yanming, N. Soranzo (7608857), Christian Fuchsberger (76512), Timothy M. Frayling (145700), Saxena, R., Samani Nilesh J., Kathleen Stirrups (145729), Teslovich, TM, Nicole Soranzo (12361), Sekar Kathiresan, Samani, Nilesh J, J. Maguire (7683200), Hirschhorn, J.N., Tanya M Teslovich, Inês Barroso, Stirrups, K, Palmer, Cameron Douglas, Palmer, Cameron D., Prokopenko, I., Soranzo, Nicole, C. Sidore (7683188), Rayner, N. William, Johnson, Toby, Voight, B.F., N. William Rayner, Randall, Joshua C., Jun Ding, Lindgren Cecilia M., Elizabeth K Speliotes, Richa Saxena, Cameron D. Palmer, Christopher Newton-Cheh, Cecilia M. Lindgren, Elizabeth K. Speliotes (145716), Nagaraja Ramaiah, Nicole Soranzo, Johnson Toby, Loos, RJ, Cucca, F, Loos Ruth J. F., Mulas, Antonella, Abecasis Gonçalo R., Anne U. Jackson (145702), Mulas, A, Teslovich Tanya M., Randall Joshua C., Rayner, NW, Heribert Schunkert, Barroso, I, Cameron D. Palmer (131509), Stirrups, Kathleen, Hirschhorn, Joel N., P. Deloukas (7603691), Barroso Inês, Gibson, Greg, Lindgren, C.M., Michael Boehnke, Schunkert, Heribert, Lindgren, CM, Loos, R.J.F., Noël P Burtt, Munroe Patricia B., C. Fuchsberger (7683191), T. M. Frayling (7608959), J. C. Randall (7611377), Kathiresan, Sekar, Frayling, T.M., Jared Maguire, M. Parkin (7683203), Christopher Newton-Cheh (79953), Tuomas O Kilpeläinen, J. Erdmann (7603664), Wheeler Eleanor, Morris, A.P., Potter, S., Kathiresan Sekar, Mulas, A., Christian Fuchsberger, Joshua C. R, Cucca Francesco, K. Stirrups (7683206), M. I. McCarthy (7609121), Simon Potter, Anne U. Jackson, Hirschhorn, JN, A. P. Morris (7611419), N. P. Burtt (7605932), Benjamin F, Nilesh J Samani, R. Nagaraja (7612157), Kilpeläinen Tuomas O. +395 morecore +1 more sourceIMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd +9 morewiley +1 more sourceCharacterization of Aggregatibacter actinomycetemcomitans Serotype b Strains with Five Different, Including Two Novel, Leukotoxin Promoter Structures
Vaccines, 2020 The JP2 genotype of A. actinomycetemcomitans, serotype b has attracted much interest during the past three decades due to its close association with periodontitis in young individuals and the enhanced expression of a leukotoxin (LtxA).Rolf Claesson, Huei-Min Chiang, Mark Lindholm, Carola Höglund Åberg, Dorte Haubek, Anders Johansson, Jan Oscarsson +6 moredoaj +1 more sourceGenotyping pooled DNA using 100K SNP microarrays: a step towards genomewide association scans [PDF]
, 2006 The identification of quantitative trait loci (QTLs) of small effect size that underlie complex traits poses a particular challenge for geneticists due to the large sample sizes and large numbers of genetic markers required for genomewide association ...Plomin, R., Meaburn, Emma L., Leonard C. Schalkwyk, Robert Plomin, Emma Meaburn, Butcher, L.M., Plomin, R, Butcher, LM, Meaburn, E, Schalkwyk, LC, Schalkwyk, L.C., Butcher, L M, Schalkwyk, L C, Lee M. Butcher, Meaburn, EL +14 morecore +1 more sourceDifferential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales +11 morewiley +1 more source
