Results 51 to 60 of about 456,399 (317)

Characterization of putative germline pathogenic variants in 27 candidate cancer-predisposing genes in 813 cats using a feline-specific multiplex targeted sequencing

Scientific Reports
In humans, about 5–10% of all cancers are caused by germline pathogenic variants (PVs) in cancer-predisposing genes, and their identification enables precision oncology approaches, such as surveillance for early detection, preventive medicine, and ...
Namiko Ikeda, Keijiro Mizukami, Ryoko Yamada, Hiroto Toyoda, Tomomi Aoi, Mikiko Endo, Yusuke Iwasaki, Daiki Kato, Takayuki Nakagawa, Ryohei Nishimura, Hirotaka Tomiyasu, Yukihide Momozawa   +11 more
doaj   +1 more source

Transference of the Term "Genotype" [PDF]

Science, 1911
n ...
Bather, F. A., Calman, W. T.
openaire   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Analysis of Whole-Genome Sequences of Pathogenic Gram-Positive and Gram-Negative Isolates from the Same Hospital Environment to Investigate Common Evolutionary Trends Associated with Horizontal Gene Exchange, Mutations and DNA Methylation Patterning

Microorganisms, 2023
Hospital-acquired infections are a generally recognized problem for healthcare professionals. Clinical variants of Gram-negative and Gram-positive pathogens are characterized with enhanced antibiotic resistance and virulence due to mutations and the ...
Ilya S. Korotetskiy, Sergey V. Shilov, Tatyana Kuznetsova, Bahkytzhan Kerimzhanova, Nadezhda Korotetskaya, Lyudmila Ivanova, Natalya Zubenko, Raikhan Parenova, Oleg N. Reva   +8 more
doaj   +1 more source

Wheat seed demand assessment assisted by genotyping in Ethiopia

, 2023
This study examines the extent to which wheat varieties supplied by the formal seed system align with the varieties demanded and used by farmers in Ethiopia.
Moti Jaleta, Yirga, C., Fantaye, K.T., Debello, M.J., Chilot Yirga, Bekele, A., Erenstein, O., Olaf Erenstein, Kindie Tesfaye, Endeshaw Habte, Habte, E., Adam Bekele   +11 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Pan-cancer prevalence, risk, and clinical and demographic characteristics of Lynch Syndrome-associated variants in BioBank Japan

Communications Medicine
Background Although germline testing for DNA mismatch repair (MMR) genes is routinely performed, clinical guidelines highlight evidence gaps due to limited populations and biases.
Keijiro Mizukami, Yoshiaki Usui, Yusuke Iwasaki, Kouya Shiraishi, Makoto Hirata, Yoichiro Kamatani, Mikiko Endo, Satoshi Takahashi, Yoshiki Mochizuki, Mitusyo Yamaguchi, Takashi Kohno, Koichi Matsuda, Kokichi Sugano, Teruhiko Yoshida, Hidewaki Nakagawa, Chikashi Terao, Yuriko N. Koyanagi, Keitaro Matsuo, Yoshinori Murakami, Amanda B. Spurdle, Yukihide Momozawa   +20 more
doaj   +1 more source

Genotype calling in tetraploid species from bi-allelic marker data using mixture models [PDF]

, 2011
Background Automated genotype calling in tetraploid species was until recently not possible, which hampered genetic analysis. Modern genotyping assays often produce two signals, one for each allele of a bi-allelic marker.
Vosman Ben, Gort, G., Gort Gerrit, Voorrips Roeland E, Roeland E Voorrips, Gerrit Gort, Voorrips, R.E., Vosman, B., Ben Vosman   +8 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source