Results 61 to 70 of about 456,399 (317)

METHODOLOGICAL APPROACHES TO MYCOBACTERIUM TUBERCULOSIS GENOTYPING FOR EVOLUTIONARY AND EPIDEMIOLOGICAL RESEARCH

Инфекция и иммунитет, 2014
. Current genome evolution of Mycobacterium tuberculosis is marked by virtual absence of the lateral gene transfer leading to the clonal population of this species consisting of separate genetic families. Standard typing method of M. tuberculosis (IS6110-
I. V. Mokrousov
doaj   +1 more source

Priors for Genotyping Polyploids [PDF]

Bioinformatics, 2019
Abstract Motivation Empirical Bayes techniques to genotype polyploid organisms usually either (i) assume technical artifacts are known a priori or (ii) estimate technical artifacts simultaneously with the prior genotype distribution.
Gerard, David, Ferrão, Luís Felipe Ventorim   +1 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Rapid and Sensitive Detection of BLAD in Cattle Population

Scientific Papers Animal Science and Biotechnologies, 2023
Bovine leukocyte adhesion deficiency (BLAD) is an autosomal recessive disorder with negative impact on dairy cattle breeding. The molecular basis of BLAD is a single point mutation (A→G), resulting in a single amino acid substitution (aspartic acid ...
Daniela Elena Ilie, Ada Cean, Oana Isabella Gavriliuc, Nicolae Păcală   +3 more
doaj  

MOLECULAR-GENETIC BASIS OF PHYSIOLOGY AND PATHOGENICITY OF COXIELLA BURNETII

Инфекция и иммунитет, 2014
. The agent of Q-fever Coxiella burnetii is unusual intracellular pathogen which is possessed of biggest transporting and metabolic abilities in compare with microorganisms with similar parasitic strategy.
Yu. A. Panpherova
doaj   +1 more source

Utility of the pooling approach as applied to whole genome association scans with high-density Affymetrix microarrays. [PDF]

, 2010
Background: We report an attempt to extend the previously successful approach of combining SNP (single nucleotide polymorphism) microarrays and DNA pooling (SNP-MaP) employing high-density microarrays.
Farmer, A., Pirlo Katrina, Farmer, Anne E, Gray, J, Jones, L, Emma Meaburn (27672), Ian W Craig (16171385), Gaysina, D, Ian W Craig, Emma Meaburn, Craig, I., Korszun Ania, Cohen-Woods Sarah, Gray Joanna, Cohen-Woods, Sarah, Schalkwyk, L.C., McGuffin Peter, Darya Gaysina, Craig, Ian W, Farmer, AE, Schosser, A, Gray, J., Elkin, Amanda, Schalkwyk, L., Gray, Joanna, Craig, IW, Schalkwyk Leonard C, Schosser Alexandra, Lisa Jones (98953), Gunasinghe, C, Sarah Cohen-Woods (214940), Pirlo, K., Craig, I.W., Jones Lisa, Alexandra Schosser (214931), Gaysina Darya, Cerisse Gunasinghe (16171376), Schosser, Alexandra, McGuffin, P., Meaburn Emma, Meaburn, E., Amanda Elkin, Leonard C Schalkwyk, Alexandra Schosser, Ania Korszun (214946), Anne E Farmer, Joanna Gray, Lisa Jones, McGuffin, P, Pirlo, Katrina, Elkin Amanda, Katrina Pirlo, Gaysina, Darya, Schosser, A., Elkin, A., Schalkwyk, LC, Korszun, A., Peter McGuffin, Gunasinghe, Cerisse, Amanda Elkin (16049114), Craig Ian W, Sarah Cohen-Woods, Joanna Gray (16171373), Anne E Farmer (10497512), Farmer Anne E, Gaysina, Daria, Ania Korszun, Pirlo, K, Gunasinghe, C., Peter McGuffin (51507), Meaburn, Emma L., Elkin, A, Katrina Pirlo (14918094), Gaysina, D., Cerisse Gunasinghe, Korszun, A, Farmer, A.E., McGuffin, Peter, Korszun, Ania, Jones, Lisa, Leonard C Schalkwyk (8412954), Cohen-Woods, S, McGuffin, Peter W, Meaburn, E, Darya Gaysina (4464832), Schalkwyk, Leonard C, Cohen-Woods, S., Gunasinghe Cerisse, Jones, L., Gunasinghe, Cerisse; id_orcid, Meaburn, Emma   +90 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Two new rapid SNP-typing methods for classifying Mycobacterium tuberculosis complex into the main phylogenetic lineages [PDF]

, 2012
There is increasing evidence that strain variation in Mycobacterium tuberculosis complex (MTBC) might influence the outcome of tuberculosis infection and disease.
Coscollà Mireia, David Stucki, Feldmann, Julia, Yeboah-Manu, D., Comas Iñaki, Gagneux, Sebastien, Hostettler Simon, Simon Hostettler, Thembela Huna (149818), Huna, Thembela, Huna Thembela, Malla Bijaya, Mireia Coscollà, Julia Feldmann (149820), Feldmann Julia, Stucki, David, Iñaki Comas (57109), Thembela Huna, Hostettler, S., Comas, Iñaki, Malla, Bijaya, Stucki David, Dorothy Yeboah-Manu, Sonia Borrell, David Stucki (149811), Huna, T., Gagneux, S., Yeboah-Manu, Dorothy, Fenner, Lukas, Borrell, Sonia, Dorothy Yeboah-Manu (120059), Comas, I., Bijaya Malla, Gagneux Sebastien, Fenner, L., Borrell Sonia, Hostettler, Simon, Lukas Fenner, Fenner Lukas, Bijaya Malla (149813), Sebastien Gagneux (149824), Mireia Coscollà (149823), Coscollà, Mireia, Sebastien Gagneux, Malla, B., Simon Hostettler (149816), Sonia Borrell (149821), Borrell, S., Julia Feldmann, Coscolla, M., Yeboah-Manu Dorothy, Lukas Fenner (149822), Iñaki Comas, Feldmann, J., Stucki, D.   +54 more
core   +3 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source