Results 161 to 170 of about 181,932 (222)

Loss of Golga7 Suppresses Oncogenic Nras‐Driven Leukemogenesis without Detectable Toxicity in Adult Mice

Advanced Science, EarlyView.
NRAS mutations are widespread in hematologic malignancies. Our study shows that GOLGA7 serves as a safe and effective therapeutic target for NRAS‐driven leukemia. Loss of Golga7 in adult mice effectively suppresses NrasG12D‐driven myeloproliferative neoplasm by disrupting its PM localization and impairing subsequent MAPK signaling, without affecting ...
Bo Jiao, Lei Yan, Rui Zhang, Wei Huang, Xinru Wang, Chenxuan Liu, Peihong Wang, Pengfei Xu, Jinzeng Wang, Zhou Fang, Donghe Li, Zhizhou Xia, Jiaoyang Li, Shiyu Ji, Qianqian Zhang, Min Wu, Shengyue Wang, Ping Liu, Ruibao Ren   +18 more
wiley   +1 more source

Differences in competitive ability between genotypes of Drosophila [PDF]

, 1962
Kenneth Mather, Patricia Cooke
openalex   +1 more source

Genome‐Wide Association Studies Reveal the Genetic Architecture of Ionomic Variation in Grains of Tartary Buckwheat

Advanced Science, EarlyView.
In this study, variation and genetic basis of ionome among Tartary buckwheat population are investigated, illuminating their significance in the domestication and diversification of Tartary buckwheat. And three genes (FtACA13 for Na content, FtYPQ1 for Zn content, FtNHX2 for As content) are identified with the dominant haplotypes and functional ...
Zhirong Wang, Yuqi He, Mengyu Zhao, Xiang‐Qian Liu, Hao Lin, Yaliang Shi, Kaixuan Zhang, Guijie Lei, Dili Lai, Tong Liu, Xiaoyang Peng, Jiayue He, Wei Li, Xiangru Wang, Sun‐Hee Woo, Muriel Quinet, Alisdair R. Fernie, Xin‐Yuan Huang, Meiliang Zhou   +18 more
wiley   +1 more source

THE ENVIRONMENTAL INDUCTION OF HERITABLE CHANGES IN NICOTIANA RUSTICA. EFFECTS OF GENOTYPE-ENVIRONMENT INTERACTIONS [PDF]

, 1969
Jonathan R. Hill, Jean M Perkins
openalex   +1 more source

Leveraging Automated Machine Learning for Environmental Data‐Driven Genetic Analysis and Genomic Prediction in Maize Hybrids

Advanced Science, EarlyView.
An automated machine learning framework integrating environmental and genomic data enhances genetic analysis and genomic prediction in maize. By leveraging dimension‐reduced environmental parameters, it reveals trait‐environment relationships and identifies genetic markers that govern phenotypic plasticity and genotype‐by‐environment interactions.
Kunhui He, Tingxi Yu, Shang Gao, Shoukun Chen, Liang Li, Xuecai Zhang, Changling Huang, Yunbi Xu, Jiankang Wang, Boddupalli M. Prasanna, Sarah Hearne, Xinhai Li, Huihui Li   +12 more
wiley   +1 more source

EFFECT OF TEMPERATURE DURING GROWTH ON LEAF ANATOMY AND SUBSEQUENT LIGHT‐SATURATED PHOTOSYNTHESIS AMONG CONTRASTING LOLIUM GENOTYPES [PDF]

, 1969
Deborah J. Wilson, J. P. Cooper
openalex   +1 more source

DPImpute: A Genotype Imputation Framework for Ultra‐Low Coverage Whole‐Genome Sequencing and its Application in Genomic Selection

Advanced Science, EarlyView.
DPImpute is a two‐step pipeline that outperforms existing tools in whole‐genome SNP imputation, particularly under conditions of ultra‐low coverage sequencing, small sample sizes, and limited references. It enables precise imputation for single blastocyst cells, supporting genomic selection at the pre‐implantation stage.
Weigang Zheng, Wenlong Ma, Zhilong Chen, Chao Wang, Tao Sun, Wenjun Dong, Wenjing Zhang, Song Zhang, Zhonglin Tang, Kui Li, Yunxiang Zhao, Yuwen Liu   +11 more
wiley   +1 more source

Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea

Advanced Science, EarlyView.
This study indicates that Serpine2 plays a pivotal role in hair cell (HC) regeneration from Lgr5+ progenitors in the neonatal mouse cochlea. Conditional overexpression of Serpine2 in cochlear Lgr5+ progenitors results in a significantly increased number of ectopic HCs, particularly ectopic inner HCs, and these HCs are likely derived from Lgr5 ...
Hairong Xiao, Jiheng Wu, Lixuan Huang, Ying Ma, Leilei Wu, Yanqin Lin, Zixuan Ye, Xin Tan, Xujun Tang, Wei Tong, Mingchen Dai, Yintao Wang, Xia Sheng, Renjie Chai, Shasha Zhang   +14 more
wiley   +1 more source

Editorial: Brief research reports in pharmacogenetics and pharmacogenomics: 2022

Frontiers in Pharmacology, 2023
Francesco Sessa, Tarek Magdy, Tarek Magdy, Chonlaphat Sukasem, Chonlaphat Sukasem, George P. Patrinos, George P. Patrinos, George P. Patrinos   +7 more
doaj   +1 more source

THE PATTERN OF VIABILITY CHANGES ASSOCIATED WITH GENOTYPE FREQUENCY AT THE ALCOHOL DEHYDROGENASE LOCUS IN A POPULATION OF DROSOPHILA MELANOGASTER

, 1969
Ken-Ichi Kojima, Yoshiko N. Tobari
openalex   +2 more sources