Results 191 to 200 of about 1,163,135 (344)

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

Age Is Just a Number: No Impacts of Scat Ageing on Single Nucleotide Polymorphism Genotyping Using a Target Capture Approach. [PDF]

Ecol Evol
Levengood AL, Hohwieler K, Powell D, Cristescu RH.   +3 more
europepmc   +1 more source

THE PATTERN OF VIABILITY CHANGES ASSOCIATED WITH GENOTYPE FREQUENCY AT THE ALCOHOL DEHYDROGENASE LOCUS IN A POPULATION OF DROSOPHILA MELANOGASTER

, 1969
Ken-Ichi Kojima, Yoshiko N. Tobari
openalex   +2 more sources

EFFECT OF TEMPERATURE DURING GROWTH ON LEAF ANATOMY AND SUBSEQUENT LIGHT‐SATURATED PHOTOSYNTHESIS AMONG CONTRASTING LOLIUM GENOTYPES [PDF]

, 1969
Deborah J. Wilson, J. P. Cooper
openalex   +1 more source

Comprehensive Characterization of Bihormonal Cells and Endocrine Cell Lineages in Mammalian Pancreatic Islets

Advanced Science, EarlyView.
This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu, Peng Peng, Yi‐Ning Wang, Mao‐Yang He, Shuang He, Chen‐Tao Jin, Liu Yang, Xi Wang, Jia‐Xi Zheng, Jie Gao, Cheng‐Ran Xu   +10 more
wiley   +1 more source

Weak D phenotype in transfusion medicine and obstetrics: Challenges and opportunities. [PDF]

World J Exp Med
Sainath PB, Ramaiyan V.
europepmc   +1 more source

Predictive genotype [PDF]

Canadian Medical Association Journal, 2010
Shinya, Ito, Bruce C, Carleton
openaire   +2 more sources

Rictor Ameliorates Acute Antibody‐Mediated Rejection Following Kidney Transplantation by Suppressing Macrophage M1 Polarization Through p65‐NLRP3 Axis

Advanced Science, EarlyView.
This study elucidates the critical role of Rictor in macrophage activation in acute antibody‐mediated rejection (ABMR). Rictor increases K48‐linked ubiquitination of p65 by upregulating E3 ubiquitin ligase SOCS1, inhibiting transcriptional levels of NLRP3 and inflammasome activation.
Bin Ni, Chengcheng Yang, Junqi Zhang, Zhou Hang, Ming Zheng, Dengyuan Feng, Qinghuan Shen, Jinxu Miao, Xulin Sun, Li Sun, Baixin Shen, Min Gu, Zijie Wang   +12 more
wiley   +1 more source

Development and application of a cost-effective multiplex Kompetitive Allele-Specific polymerase chain reaction assay for pyramiding resistant genes of fusarium head blight and powdery mildew in wheat. [PDF]

BMC Plant Biol
Wang Y, Yang J, Gao Y, Ma H, Dai Y, Ma H.   +5 more
europepmc   +1 more source

Integration of the Genotype in Geographic Populations of Drosophila pavani [PDF]

, 1961
Danko Brncić
openalex   +1 more source