Results 251 to 260 of about 1,163,135 (344)

METTL3/ALKBH5‐Mediated N6‐Methyladenosine Modification Drives Macrophage M1 Polarization via the SLC15A3‐TASL‐IRF5 Signaling Axis in Psoriasis

Advanced Science, EarlyView.
m6A modification stabilizes Slc15a3 mRNA in macrophages, activating the SLC15A3‐TASL‐IRF5 axis and promoting psoriatic inflammation. Abstract Impaired N6‐methyladenosine (m6A) modification has been implicated in regulating various inflammatory diseases, but its role in psoriasis remains unclear.
Tao Huang, Shijun Chen, Ke Ding, Liyan Yuan, Weiqi Lv, Kechen Chen, Yuchen Liu, Dongzhao Ma, Xin Zhang, Xiaobo Wang, Guanzheng Luo, Bin Yang, Ying Lin, Zhili Rong   +13 more
wiley   +1 more source

Optimized multiplex PCR-NGS for comprehensive HLA genotyping in Chinese populations: resolving ambiguities at high resolution. [PDF]

Front Immunol
Haider CG, Sun B, Wang Y, Zhang Z, Cao C, Zhu Y, Abdelhak O, Huang H, Liu H, Jiang T, Dong X, Zhou Y, Wu Y.   +12 more
europepmc   +1 more source

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Navigating the Genetic Landscape: Investigating the Opportunities and Risks of Cross-Species SNP Array Application in Catfish. [PDF]

Genes (Basel)
Hegedűs B, Bagi Z, Kusza S.
europepmc   +1 more source

A single domestication for maize shown by multilocus microsatellite genotyping

Proceedings of the National Academy of Sciences of the United States of America, 2002
Y. Matsuoka, Y. Vigouroux, M. Goodman, J. Sanchez G., E. Buckler, J. Doebley   +5 more
semanticscholar   +1 more source

Genotype × environment interactions [PDF]

Genetics Selection Evolution, 1972
openaire   +4 more sources

Extracellular LCN2 Binding to 24p3R in Astrocytes Impedes α‐Synuclein Endocytosis in Parkinson's Disease

Advanced Science, EarlyView.
24p3R is an astrocytic receptor for α‐Syn uptake. When LCN2 is secreted from astrocytes, it binds to its receptor 24p3R in astrocytes and this binding impedes the α‐Syn PFF binding to 24p3R. This in turn inhibits 24p3R‐mediated α‐Syn PFF uptake and reduces the clearance of extracellular α‐Syn by astrocytes, which contributes to α‐Syn spread and ...
Ying‐Ying Jiao, Tian Tian, Zhu Zhu, Lei Cao, Yang Liu, Rui‐An Wang, Zhi‐Yong Zhou, Cong Wang, Ke‐Zhong Zhang, Xiao Lu, Wen‐Wei Yun, Ying‐Mei Lu, Gang Hu, Ren‐Hong Du, Ming Lu   +14 more
wiley   +1 more source

CRISPR/Cas12a-Based One-Tube RT-RAA Assay for PoRV Genotyping. [PDF]

Int J Mol Sci
Bi M, Wang Z, Li K, Ren Y, Ma D, Mo X.
europepmc   +1 more source

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

Endocervical Curettage and Extended HPV Genotyping as Predictors of Residual Disease After Hysterectomy in Postmenopausal Women Previously Treated with LEEP for CIN3: A Multivariate Analysis. [PDF]

Cancers (Basel)
Bruno MT, Cavallaro AG, Fiore M, Ruggeri Z, Somma M, Pagana A, Mascellino G, Laganà AS.   +7 more
europepmc   +1 more source