Results 121 to 130 of about 10,219,641 (384)

Designing for Degradation: Transient Devices Enabled by (Nano)Cellulose

open access: yesAdvanced Materials, EarlyView.
Recent progress in transient devices enabled by (nano)cellulosic materials is reviewed. Transiency mechanisms, advantages of nanocelluloses, and a suite of applications are discussed. A circular thinking approach coupled with life cycle assessment is applied to critically revisit the potential, advantages, and challenges of nanocellulose‐enabled ...
Lucas J. Andrew   +2 more
wiley   +1 more source

RHD genotyping by allele specific “Loop-mediated isothermal DNA Amplification”

open access: yesBioingeniøren, 2014
Background: The “Rh” cluster, with its main antigen D, is the most important blood group system after “ABO”. Because anti-D antibodies can cause hemolytic disease of the fetus and newborn as well as hemolytic transfusion reactions, phenotyping for RhD is
Thomas Hundhausen   +3 more
doaj  

Novel directions in data pre-processing and genome-wide association study (GWAS) methodologies to overcome ongoing challenges

open access: yesInformatics in Medicine Unlocked, 2021
A genome-wide association study (GWAS) is a standard population-based technique for identifying the heritable genetic basis of complex diseases by discovering correlations between trait variations and allele frequencies of genetic markers.
Zahra Mortezaei, Mahmood Tavallaei
doaj  

Estimating a Brain Network Predictive of Stress and Genotype with Supervised Autoencoders [PDF]

open access: yesarXiv, 2020
Targeted stimulation of the brain has the potential to treat mental illnesses. We propose an approach to help design the stimulation protocol by identifying electrical dynamics across many brain regions that relate to illness states. We model multi-region electrical activity as a superposition of activity from latent networks, where the weights on the ...
arxiv  

High‐Resolution Patterned Delivery of Chemical Signals From 3D‐Printed Picoliter Droplet Networks

open access: yesAdvanced Materials, EarlyView.
3D‐printed picoliter droplet networks have been fabricated that control gene expression in bacterial populations by releasing chemical signals with precise spatial definition and high temporal resolution. This system of effector release is widely applicable, offering diverse applications in biology and medicine.
Jorin Riexinger   +7 more
wiley   +1 more source

Genomic Characterization of the Vaccinal Strain of Mycobacterium Avium Subspecies Paratuberculosis (MAP) 316F by MIRU-VNTR

open access: yesMedical Laboratory Journal, 2015
Background and Objective: Paratuberculosis is a chronic granulomatous enteritis of ruminants caused by Mycobacterium avium subspecies paratuberculosis (MAP). this study aimed to characterize the genome of the MAP 316F strain.
Zahra Ebrahim   +2 more
doaj  

Algorithms for Large-scale Whole Genome Association Analysis [PDF]

open access: yesarXiv, 2013
In order to associate complex traits with genetic polymorphisms, genome-wide association studies process huge datasets involving tens of thousands of individuals genotyped for millions of polymorphisms. When handling these datasets, which exceed the main memory of contemporary computers, one faces two distinct challenges: 1) Millions of polymorphisms ...
arxiv  

Immune Checkpoint PD‐L1 Modulates Retinal Microglial Activation to Alleviate Vascular Leakage in Choroidal Neovascularization via ERK

open access: yesAdvanced Science, EarlyView.
PD‐L1 limits neuroinflammation in neovascular AMD by modulating microglial activation. Its deficiency exacerbates vascular leakage and choroidal neovascularization (CNV) via ERK signaling, while enhancing PD‐L1 reduces inflammation and neovascularization. Targeting PD‐L1 may offer a novel immunomodulatory strategy for NVAMD.
Yue Zou   +7 more
wiley   +1 more source

The reintroduction of the Eurasian otter (Lutra lutra) into the Netherlands: hidden life revealed by noninvasive genetic monitoring [PDF]

open access: yes, 2010
The last recorded presence of the Eurasian otter (Lutra lutra) in the Netherlands dates from 1989 and concerned a dead individual. In 2002 a reintroduction programme was started, and between June 2002 and April 2008 a total of 30 individuals (10 males ...
Boerwinkel, M.C.   +7 more
core   +5 more sources

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

open access: yesAdvanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu   +8 more
wiley   +1 more source

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