Results 131 to 140 of about 83,652 (291)

Using DNA pools for genotyping trios

, 2006
The genotyping of mother–father–child trios is a very useful tool in disease association studies, as trios eliminate population stratification effects and increase the accuracy of haplotype inference.
Andreas Braun, Eran Halperin, Kenneth B. Beckman, Kenneth J. Abel   +3 more
core  

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Results of highlighting genes associated with ethylene production in apple genotypes cultivated in Romania

Romanian Journal of Horticulture
Molecular screening using SSLP and CAPS techniques enabled the genotyping of 40 apple cultivars developed at the main national research centres in Romania.
Adina Floricica Iancu, Mădălina Militaru, Sina Niculina Cosmulescu   +2 more
doaj   +1 more source

Molecular methods for genotyping complex copy number polymorphisms

, 2013
Genome structural variation shows remarkable complexity with respect to copy number, sequence content and distribution. While the discovery of copy number polymorphisms (CNP) has increased exponentially in recent years, the transition from discovery to ...
Baird, Paul N., Cantsilieris, Stuart, White, Stefan J.   +2 more
core   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

MODERN METHODS APPLICATION OF GENOTYPING OF INFECTIOUS DISEASES PATHOGENS IN THE CONTEXT OF OPERATIONAL WORK OF SPECIALIZED ANTI-EPIDEMIC TEAM DURING THE XXII OLYMPIC WINTER GAMES AND XI PARALYMPIC WINTER GAMES

Журнал микробиологии, эпидемиологии и иммунобиологии, 2015
This paper considers the experience of genotyping and sequencing technologies in laboratories of specialized anti-epidemic team (SAET) during the XXII Olympic Winter Games and XI Paralympic Winter Games of 2014 in Sochi.
B. P Kuzkin, A. N Kulichenko, A. S Volynkina, D. V Efremenko, I. V Kuznetsova, E. S Kotenev, G. I Lyamkin, N. N Kartsev, V. P Klindukhov   +8 more
doaj  

Handbook for TB controllers, epidemiologists, laboratorians, and other program staff [PDF]

"This guide provides an introduction to the application of tuberculosis (TB) genotyping to TB control practices and to the Centers for Disease Control and Prevention (CDC) TB Genotyping Program.

core  

The future of genotyping

, 2022
The future of genotyping is sequencing. A wide variety of technologies are available, but cost effective low coverage methods need further development. The downstream bioinformatics and statistics also have to be able handle the incomplete and noisy data
Ken Dodds (3501542), Rudiger Brauning (47247), Suzanne Rowe (5644199), Kathryn McRae (15394220), Timothy Bilton (15394454), Shannon Clarke (3504989), Melanie Hess (3587744), John McEwan (45371), Rayna Anderson (3504983), Alan McCulloch (517237)   +9 more
core  

eQTL Meta‐Analysis Reveals Conserved and Population‐Specific Regulatory Variation Underlying Nutritional Trait Evolution and Domestication in Tomato

Advanced Science, EarlyView.
A comprehensive meta‐analysis of expression quantitative trait loci (eQTLs) across five diverse tomato populations reveals a high‐resolution atlas of transcriptional regulation and uncovers conserved and population‐specific regulatory architectures underlying fruit nutritional quality traits, including flavonoids, sugars, organic acids, carotenoids ...
Jiantao Zhao, Xin Wang, Jing Zhang, Ryan McQuinn, Je Min Lee, Itay Gonda, Ari Feder, Yimin Xu, Baike Wang, Qinghui Yu, Denise M. Tieman, Sanwen Huang, Harry Klee, James J. Giovannoni, Zhangjun Fei   +14 more
wiley   +1 more source