Results 121 to 130 of about 83,652 (291)

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Molecular typing of Salmonella Typhimurium isolates using repetitive sequence- based PCR: Insights into genetic relatedness beyond antibiotic resistance

Indian Journal of Animal Sciences
Multidrug resistant non-typhoidal Salmonella infections are a threat to food safety impacting human health in the form of hospitalizations and in severe cases, fatalities.
KUMAR SIVA V, MAANSI, KUMAR SUMAN M, UPADHYAY A K   +3 more
doaj   +1 more source

Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease

Advanced Science, EarlyView.
Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang, Qingqing Zhang, Xiuxiu Wang, Lixin Peng, Xinru Ji, Jiawei Wang, Yusi Zhang, Jiayang Huang, Junchao Yang, Shiqi Zhan, Yiping Xiao, Weilin Liu, Lidian Chen   +12 more
wiley   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Sequence-based genotyping HPV L1 DNA and RNA transcripts in clinical specimens

, 2009
We developed a direct sequence-based genotyping method to detect single and multiple HPV L1 DNA and RNA types in genital and dermatological specimens.
Satra, M., Sioutopoulou, D.O., Sotiriou, S., Vamvakopoulou, D.N., Kollia, P., Kiritsaka, A., Costantoulakis, P., Vamvakopoulos, N.C., Antonakopoulos, G., Alexandris, E.   +9 more
core   +2 more sources

PREVALENCE OF CELIAC DISEASE PREDISPOSING GENOTYPES, INCLUDING HLA-DQ2.2 VARIANT, IN BRAZILIAN CHILDREN

Arquivos de Gastroenterologia
BACKGROUND: Celiac disease is an autoimmune enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Almost all celiac patients carry immune recognition genes coding for HLA-DQ2.5 and DQ8 heterodimers.
Nicole SELLESKI, Lucas Malta ALMEIDA, Fernanda Coutinho de ALMEIDA, Claudia Beatriz PRATESI, Yanna Karla de Medeiros NÓBREGA, Lenora GANDOLFI   +5 more
doaj   +1 more source

Accurate determination of phenotypic information from historic thoroughbred horses by single base extension

, 2010
Historic DNA have the potential to identify phenotypic information otherwise invisible in the historical, archaeological and palaeontological record. In order to determine whether a single nucleotide polymorphism typing protocol based on single based ...
Michael G Campana, Ceiridwen J. Edwards, Edwards Ceiridwen J., Matthew M. Binns, Ceiridwen J Edwards, Frauke Stock, Murphy, A., Cambridge, Campana, M G, Edwards, C J, Binns, Matthew M., Mim A. Bower, Binns Matthew M., Fleischer, Robert C., Graeme W. W. Barker, C. Mark Whitten, Stock Frauke, Binns, M M, Graeme W W Barker, Campana, M., Barker, Graeme W. W., Campana Michael G., Bower Mim A., Barker Graeme W. W., Campana, Michael G., Trinity College Dublin, Bower, Mim A., Bower, M., Barker, G W W, Mim A Bower, Barker, G., Murphy Angela M., Murphy, A M, Michael G. Campana, Edwards, C., C Mark Whitten, Stock, Frauke, Bower, M A, Stock, F., Whitten, C. Mark, Binns, M., Whitten, C M, Angela M Murphy, Angela M. Murphy, Matthew M Binns, Whitten C. Mark, Whitten, C., Edwards, Ceiridwen J., Stock, F, Murphy, Angela M.   +49 more
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Sequencing vs. amplification for the estimation of allele dosages in sugarcane (Saccharum spp.)

Applications in Plant Sciences
Premise Detecting single‐nucleotide polymorphisms (SNPs) in a cost‐effective way is fundamental in any plant breeding pipeline. Here, we compare three genotyping techniques for their ability to reproduce the allele dosage of SNPs of interest in sugarcane
Hugo Jaimes, Alejandra Londoño, Carolina Saavedra‐Diaz, Jhon Henry Trujillo‐Montenegro, Jershon López‐Gerena, John J. Riascos, Fernando S. Aguilar   +6 more
doaj   +1 more source