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Synthesis of Gentamicins C1, C2, and C2a and Antiribosomal and Antibacterial Activity of Gentamicins B1, C1, C1a, C2, C2a, C2b, and X2 [PDF]
ACS Infectious Diseases, 2023 Complementing our earlier syntheses of the gentamicins B1, C1a, C2b, and X2, we describe the synthesis of gentamicins C1, C2, and C2a characterized by methyl substitution at the 6'-position, and so present an alternative access to previous ...
Andrea Vasella +2 more
exaly +6 more sources
Identification and Quantification of the Component Composition of the Active Substance Gentamicin Sulfate by 1Н and 13С NMR Spectroscopy [PDF]
, 2023 Gentamicin sulfate is a broad-spectrum bactericidal aminoglycoside antibiotic produced by Micromonospora purpurea and used in clinical practice as an active substance containing a mixture of gentamicins C1 and C2.
E. P. Simonova +4 more
core +3 more sources
Streptomycin, Dihydrostreptomycin, and the Gentamicins
, 1975 Gerald Medoff, David Schlessinger
exaly +2 more sources
Der Einfluß einer Anämie auf die Ototoxizität des Gentamicins
, 1991 W. Delb, A. Koch, P. Federspil
exaly +2 more sources
Synthesis of Gentamicin Minor Components: Gentamicin B1 and Gentamicin X2
Organic Letters, 2020 The clinical aminoglycoside antibiotic gentamicin is a mixture of several difficult-to-separate major and minor components. The relative inaccessibility of the minor components in particular complicates efforts to separate antibacterial activity from nephro- and/or ototoxicity and to clarify the origin of the potentially therapeutically important read ...
Parasuraman Rajasekaran, David Crich
openaire +3 more sources
Methyltransferases of gentamicin biosynthesis [PDF]
, 2018 Gentamicin C complex from Micromonospora echinospora remains a globally important antibiotic, and there is revived interest in the semisynthesis of analogs that might show improved therapeutic properties. The complex consists of five components differing
Anna Reva +8 more
core +3 more sources
Enzymology of Gentamicin Biosynthesis [PDF]
, 2018 Gentamicin C complex is a mixture of five structurally similar aminoglycoside antibiotics, gentamicins C1, C1a, C2, C2a, and C2b, produced by the actinomycete bacterium Micromonospora echinospora. It is established in clinical use and despite significant
core +2 more sources
Specificity and Promiscuity at the Branch Point in Gentamicin Biosynthesis [PDF]
, 2014 SummaryGentamicin C complex is a mixture of aminoglycoside antibiotics used to treat severe Gram-negative bacterial infections. We report here key features of the late-stage biosynthesis of gentamicins.
Guo, Junhong +8 more
core +1 more source
, 2019 Gentamicins are clinically relevant aminoglycoside antibiotics produced by several Micromonospora species. Gentamicins are highly methylated and functionalized molecules, and their biosynthesis include glycosyltransferases, dehydratase/oxidoreductases ...
Parise-Filho, Roberto +20 more
core +1 more source