Glycodiversification of gentamicins through in vivo glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity [PDF]
Acta Pharmaceutica Sinica BAminoglycosides (AGs) are a class of antibiotics with a broad spectrum of activity. However, their use is limited by safety concerns associated with nephrotoxicity and ototoxicity, as well as drug resistance.
Yuhui Sun, Shijuan Wu, Xinyun Jian
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Differential modulation of gentamicin antibacterial activity by vitamin B12 and vitamin D3 against Gram-positive and Gram-negative bacteria: an in vitro–in silico study [PDF]
Annals of MedicineIntroduction Antimicrobial resistance and gentamicin-associated toxicity necessitate the development of non-antibiotic adjuvants that enhance aminoglycoside efficacy while reducing required doses.
Imane M’hamedi +5 more
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Synthesis of Gentamicins C1, C2, and C2a and Antiribosomal and Antibacterial Activity of Gentamicins B1, C1, C1a, C2, C2a, C2b, and X2 [PDF]
ACS Infectious Diseases, 2023 Santanu Jana +2 more
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Регуляторные исследования и экспертиза лекарственных средств, 2023 Gentamicin sulfate is a broad-spectrum bactericidal aminoglycoside antibiotic produced by Micromonospora purpurea and used in clinical practice as an active substance containing a mixture of gentamicins C1 and C2.
S. V. Moiseev +4 more
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Advanced Biomedical Research, 2023 Background: Bacterial virulence factors may be influenced by sub-minimum inhibitory concentrations (sub-MICs) of antibiotics. The main purpose of this study was to investigate the effects of gentamicin at sub-MICs (0.5 MIC and 0.25 MIC) on alginate ...
Navid Saidi +3 more
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The effect of high concentration of magnesium with ropivacaine, gentamicin, rocuronium, and their combination on neuromuscular blockade [PDF]
Korean Journal of Anesthesiology, 2015 BackgroundMagnesium, ropivacaine, gentamicin, and rocuronium block neuromuscular (NM) transmission by different mechanisms. Therefore, concurrent administration of these agents may induce prolonged muscle paralysis via synergistic interaction. This study
Won Ji Rhee +6 more
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New possibilities in the treatment of Meniere's disease [PDF]
Vojnosanitetski Pregled, 2002 The results of the treatment of Meniere's disease by intratympanic instillation of gentamicin in 32 patients over a 24-months period were analyzed. The receded vestibular function was found in 96,8% patients whereas in the remaining 3,2% pronounced ...
Milanović Nada +3 more
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Protective Effect of Metformin on Gentamicin-Induced Vestibulotoxicity in Rat Primary Cell Culture [PDF]
Clinical and Experimental Otorhinolaryngology, 2014 ObjectivesOne of the antidiabetic drugs, metformin, have shown that it prevented oxidative stress-induced death in several cell types through a mechanism involving the opening of the permeability transition pore and cytochrome c release.
Ji Young Lee +5 more
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Synthesis of Gentamicin Minor Components: Gentamicin B1 and Gentamicin X2
Organic Letters, 2020 The clinical aminoglycoside antibiotic gentamicin is a mixture of several difficult-to-separate major and minor components. The relative inaccessibility of the minor components in particular complicates efforts to separate antibacterial activity from nephro- and/or ototoxicity and to clarify the origin of the potentially therapeutically important read ...
Parasuraman Rajasekaran, David Crich
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Vinpocetine improves oxidative stress and pro-inflammatory mediators in acute kidney injury
International Journal of Preventive Medicine, 2019 Background: Gentamicin-induced-acute kidney injury (AKI) is a multifaceted phenomenon which previously linked to the oxidative stress only. Vinpocetine prevents reactive free radical generation which contributed in reduction of damage.
Hayder M Al-Kuraishy +2 more
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