Results 41 to 50 of about 635 (136)

Anti-Rheumatic Properties of Gentiopicroside Are Associated With Suppression of ROS-NF-κB-NLRP3 Axis in Fibroblast-Like Synoviocytes and NF-κB Pathway in Adjuvant-Induced Arthritis

Frontiers in Pharmacology, 2020
Rheumatoid arthritis (RA) is among the most prevalent forms of autoimmunity. Gentiopicroside (Gent) is an iridoid glucoside derived from the Gentiana Macrophylla Pall which is used in traditional Chinese medicine to treat RA.
Meiling Wang, Hongyan Li, Yanfang Wang, Yanfei Hao, Yanan Huang, Xinlin Wang, Yongying Lu, Yuan Du, Fenghua Fu, Wenyu Xin, Leiming Zhang   +10 more
doaj   +1 more source

Casticin From Sanse Powder‐ In Vitro Release Medium Inhibits FAK/PI3K/AKT Phosphorylation Reducing Synovial Senescence and Alleviates Inflammation in Knee Osteoarthritis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Sanse Powder (SSP) has been shown to be effective in the clinical treatment of knee osteoarthritis (KOA), although its active components and underlying mechanisms remain unclear. In this study, we collected the in vitro release medium of SSP (SSP‐IVRM) using an in vitro release test and evaluated its pharmacological effects in a KOA rat model.
Jiangyu Liu, Peng Wu, Rui Jiang, Lishi Jie, Lei Shi, Houyu Fu, Yibao Wei, Deren Liu, Peimin Wang, Songjiang Yin, Jun Mao   +10 more
wiley   +1 more source

Alpine flora of Kashmir Himalaya: floristic assessment, life history traits and threat status

Nordic Journal of Botany, Volume 2026, Issue 7, July 2026.
Alpine ecosystems in the Himalaya are considered to be at a higher risk to anthropogenic global change drivers. The Kashmir Himalaya, located in the north‐western side of the Himalayan biodiversity hotspot, harbors a diverse alpine flora, which remains systematically little investigated.
Bilal A. Rasray, Showkeen A. Lone, Rameez Ahmad, Tajamul Islam, Hitendra Padalia, Anzar Ahmad Khuroo   +5 more
wiley   +1 more source

Traditional Chinese Medicine Modernization in Diagnosis and Treatment: Utilizing Artificial Intelligence and Nanotechnology

MedComm, Volume 7, Issue 2, February 2026.
Traditional Chinese medicine (TCM) faces great challenges during the development of modern medicine. Utilizing novel technologies such as artificial intelligence (AI) and nanotechnology facilitates TCM with great potential in precision diagnosis and improved treatments efficacy.
Wenqi Yu, Mengzhen Chen, Xueqi Tan, Xi Wei, Fan Sun, Hua Yan, Xue Xu, Hongcai Shang   +7 more
wiley   +1 more source

Preparation and Transdermal Mechanism of Juanbi Decoction‐Medicated Moxa Sticks for Joint Diseases

Biosurface and Biotribology, Volume 12, Issue 1, January/December 2026.
ABSTRACT Medicated moxa sticks were prepared by mixing the herbs in Juanbi decoction with moxa wool. The components of smoke produced by combustion of these medicated moxa sticks and pure moxa sticks were analysed by gas chromatography‐mass spectrometry.
Yan Wang, Qin Liu, Yuanyuan Hu, Ling Xu, Rubing Wang, Zhi Guo, Taowei Chen, Jun Zhao, Song Feng, Chuanrun Li, Bo Wu   +10 more
wiley   +1 more source

Daqinjiao Decoction Ameliorates CSVD via RXR‐γ/PPAR‐γ/VEGF‐α Pathway: Insights From Transcriptome Sequencing and Network Pharmacology

Journal of Cellular and Molecular Medicine, Volume 29, Issue 14, July 2025.
ABSTRACT Daqinjiao decoction (DQJD), an ancient traditional Chinese medicine formula, is clinically used in the treatment of cerebral small vessel disease (CSVD). However, the underlying molecular mechanisms by which DQJD exerts its therapeutic effects on CSVD remain elusive.
Mengna Lv, Xiaolu Yang, Xiaolu Shi, Shengxuan Cao, Wenjie Li, Mingmei Zhou, Xiaojun Gou, Ying Huang   +7 more
wiley   +1 more source

Luteoloside suppresses proliferation and metastasis of hepatocellular carcinoma cells by inhibition of NLRP3 inflammasome.

PLoS ONE, 2014
The inflammasome is a multi-protein complex which when activated regulates caspase-1 activation and IL-1β secretion. Inflammasome activation is mediated by NLR proteins that respond to stimuli. Among NLRs, NLRP3 senses the widest array of stimuli.
Shao-hua Fan, Yan-yan Wang, Jun Lu, Yuan-lin Zheng, Dong-mei Wu, Meng-qiu Li, Bin Hu, Zi-feng Zhang, Wei Cheng, Qun Shan   +9 more
doaj   +1 more source

Integrating DNA Barcoding Within an Orthogonal Approach for Herbal Product Authentication: A Narrative Review

Phytochemical Analysis, Volume 36, Issue 1, Page 7-29, January 2025.
ABSTRACT Introduction Existing methods for morphological, organoleptic, and chemical authentication may not adequately ensure the accurate identification of plant species or guarantee safety. Herbal raw material authentication remains a major challenge in herbal medicine.
Nazia Nazar, Akanksha Saxena, Anu Sebastian, Adrian Slater, Velusamy Sundaresan, Tiziana Sgamma   +5 more
wiley   +1 more source

Engineering of gentiopicroside-producing yeast strain using low-energy ion implantation mediated synthetic biology

Biotechnology & Biotechnological Equipment, 2016
To obtain an alternative source for the production of gentiopicroside, here genomic DNA segments of the medicinal plant Gentiana macrophylla were randomly transferred into Hansenula polymorpha by 25 KeV nitrogen ions (N+) at a dose of 2.5 × 1016 ions/cm2
Ting Wang, Weidong Qian, Yunfang Fu, Changlong Cai, Peihong Mao   +4 more
doaj   +1 more source

Response of selenium pools to drought stress by regulating physio‑biochemical attributes and anatomical changes in Gentiana macrophylla

Ecotoxicology and Environmental Safety
Selenium (Se), as a vital stress ameliorant, possesses a beneficial effect on mediating detrimental effects of environmental threats. However, the mechanisms of Se in mitigating the deleterious effects of drought are still poorly understood.
Yunyun Su, Feifei Fu, Xiaobin Ou, Lei Gong, Haiqing Liu, Yubu Sun   +5 more
doaj   +1 more source