Gentiopicroside—An Insight into Its Pharmacological Significance and Future Perspectives [PDF]
Cells, 2023 Gentiopicroside (GPS) is a leading component of several plant species from the Gentianaceae botanical family. As a compound with plenty of biological activities and a component of herbal drugs, GPS has an important role in the regulation of physiological
Lemonia Antoniadi +6 more
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Therapeutic efficacy and mechanisms of gentiopicroside in various diseases [PDF]
Frontiers in PharmacologyGentiopicroside (GPS), a secoiridoid glycoside found in traditional medicinal plants such as Gentiana scabra Bunge, exhibits diverse pharmacological properties, including anti-inflammatory, antioxidant, neuroprotective, hepatoprotective, antidiabetic ...
Ling Kui +13 more
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Gentiopicroside ameliorates CCl-induced liver injury in mice by regulating the PPAR-γ/Nrf2 and NF-κB/IκB signaling pathways [PDF]
Journal of International Medical Research, 2023 Objective This study explored the mechanisms by which gentiopicroside protects against carbon tetrachloride (CCl 4 )-induced liver injury. Methods Male mice were randomly assigned to the control; CCl 4 ; bifendate 100 mg/kg; or gentiopicroside 25, 50, or
Yun Zhang +4 more
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The Hepatoprotective Properties of Gentiopicroside, Sweroside, and Swertiamarin Against Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) [PDF]
BiomoleculesMetabolic dysfunction-associated steatotic liver disease (MASLD) is a metabolic disease characterised by the accumulation of fat in the liver. It is estimated that 30–38% of the world’s adult population have MASLD, making it the most prevalent global ...
Anthony O. Boateng +2 more
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Gentiopicroside modulates glucose homeostasis in high-fat-diet and streptozotocin-induced type 2 diabetic mice [PDF]
Frontiers in Pharmacology, 2023 Gluconeogenesis is closely related to the occurrence and development of type 2 diabetes mellitus (T2DM). Gentiopicroside (GPS) is the main active secoiridoid glycoside in Gentiana manshurica Kitagawa, which can improve chronic complications associated ...
Xing Wang +3 more
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Gentiopicroside-Induced gastric cancer necroptosis via the HIF-1 signaling pathway: A study involving molecular docking and experimental validation. [PDF]
PLoS ONEObjectivesGentiopicroside is an effective treatment for several types of cancer, inducing numerous forms of programmed cancer cell death. However, there are few investigations into the role of necroptosis. By utilizing molecular docking, and experimental
Bo Xiong +6 more
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Dual-Mechanism Gastroretentive Tablets with Encapsulated Gentian Root Extract [PDF]
PharmaceuticsBackground/Objectives: This study aimed to develop gastroretentive tablets based on mucoadhesive–floating systems with encapsulated gentian (Gentiana lutea, Gentianaceae) root extract to overcome the low bioavailability and short elimination half-life of
Jelena Mudrić +9 more
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Gentiopicroside Ameliorates Diabetic Peripheral Neuropathy by Modulating PPAR- Γ/AMPK/ACC Signaling Pathway [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Gentiopicroside is promising as an important secoiridoid compound against pain. The present study aimed to investigate the analgesic effect and the probable mechanism of Gentiopicroside on Diabetic Peripheral Neuropathy (DPN), and to ...
Yi Lu +6 more
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Bioactivities of Centaurium erythraea (Gentianaceae) Decoctions: Antioxidant Activity, Enzyme Inhibition and Docking Studies [PDF]
Molecules, 2019 Centaurium erythraea is recommended for the treatment of gastrointestinal disorders and to reduce hypercholesterolemia in ethno-medicinal practice. To perform a top-down study that could give some insight into the molecular basis of these bioactivities ...
Laura Guedes +5 more
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Gentiopicroside targeting AKT1 activates HIF-1α/VEGF axis promoting diabetic ulcer wound healing [PDF]
Frontiers in PharmacologyBackgoundGentiopicroside (GSP) have been proven to accelerate the healing of diabetic ulcers (DU), but the underlying molecular mechanisms remain unclear.
Xinxia Wang +5 more
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