Therapeutic Efficacy and Mechanisms of Gentiopicroside in Various Diseases [PDF]
Frontiers in PharmacologyGentiopicroside (GPS), a secoiridoid glycoside found in traditional medicinal plants such as Gentiana scabra Bunge, exhibits diverse pharmacological properties, including anti-inflammatory, antioxidant, neuroprotective, hepatoprotective, antidiabetic ...
Ling Kui
exaly +6 more sources
The Hepatoprotective Properties of Gentiopicroside, Sweroside, and Swertiamarin Against Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) [PDF]
BiomoleculesMetabolic dysfunction-associated steatotic liver disease (MASLD) is a metabolic disease characterised by the accumulation of fat in the liver. It is estimated that 30–38% of the world’s adult population have MASLD, making it the most prevalent global ...
Anthony O. Boateng +2 more
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Gentiopicroside-Induced gastric cancer necroptosis via the HIF-1 signaling pathway: A study involving molecular docking and experimental validation. [PDF]
PLoS ONEObjectivesGentiopicroside is an effective treatment for several types of cancer, inducing numerous forms of programmed cancer cell death. However, there are few investigations into the role of necroptosis. By utilizing molecular docking, and experimental
Bo Xiong +6 more
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Dual-Mechanism Gastroretentive Tablets with Encapsulated Gentian Root Extract [PDF]
PharmaceuticsBackground/Objectives: This study aimed to develop gastroretentive tablets based on mucoadhesive–floating systems with encapsulated gentian (Gentiana lutea, Gentianaceae) root extract to overcome the low bioavailability and short elimination half-life of
Jelena Mudrić +9 more
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Cellular Physiology and Biochemistry, 2018 Background/Aims: Gentiopicroside is promising as an important secoiridoid compound against pain. The present study aimed to investigate the analgesic effect and the probable mechanism of Gentiopicroside on Diabetic Peripheral Neuropathy (DPN), and to ...
Shaoli Zhou, Chulian Gong
exaly +3 more sources
Gentiopicroside targeting AKT1 activates HIF-1α/VEGF axis promoting diabetic ulcer wound healing [PDF]
Frontiers in PharmacologyBackgoundGentiopicroside (GSP) have been proven to accelerate the healing of diabetic ulcers (DU), but the underlying molecular mechanisms remain unclear.
Xinxia Wang +5 more
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Identification of active metabolites from Gentiana scabra Bunge ethanol-water extract for chicken metatarsal fracture repair [PDF]
Frontiers in PharmacologyIntroductionFractures are common clinical conditions. Gentiana scabra Bunge extract (GSE) exhibits multiple biological activities, including anti-nociceptive and anti-inflammatory effects. However, its therapeutic effects and active metabolites regarding
Yi Jiang Liu +5 more
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The chemical structure, pharmacological activity, and clinical progress of Gentianae Radix et Rhizoma [PDF]
Frontiers in PharmacologyAs pivotal medicinal resources in the Gentiana genus (Gentianaceae), Gentianae Radix et Rhizoma exhibit remarkable chemical diversity and multi-target pharmacological activities. This review highlights G.
Hongfang Liu +3 more
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The influence of rhizosphere soil microorganisms and environmental factors on gentiopicroside content in the roots and rhizomes of Gentiana scabra Bunge from Liaoning Province [PDF]
Frontiers in MicrobiologyBackgroundRhizosphere soil microorganisms, as the second genome of plants, play an important role in the formation of secondary metabolites of medicinal plants and are one of the key factors in the formation of the authenticity of medicinal materials ...
Jianming Hou +6 more
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Effect of gentiopicroside on endogenous formaldehyde homocysteine–pathway related proteins in rats with non-alcoholic steatohepatitis [PDF]
Frontiers in PharmacologyBackgroundNon-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD) characterised by high prevalence, increasing incidence among younger individuals and poor prognosis.
Jiaxin Chen +27 more
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