Results 21 to 30 of about 1,328 (198)

Gentiopicroside inhibits HMGCR/NF-κB pathway to alleviate renal fibrosis [PDF]

BMC Complementary Medicine and Therapies
Background Gentiopicroside (GSP) has been shown to effectively ameliorate renal fibrosis (RF), yet its underlying mechanisms are poorly characterized. This study investigates how GSP alleviates RF using RNA-seq and in vitro experiments.
Qingqing Xu, Feng Zhu, Ping Song, Yuemin Fang, Zhiqing Bai, Tao Cheng   +5 more
doaj   +2 more sources

Nanodelivery of Gentiopicroside for Inflammatory Skin Lesions: Insights from Psoriasis and Diabetic Foot Ulcers [PDF]

International Journal of Nanomedicine
Wenjie Wang,1 Libo Du,2 Huanfeng Ye,2 Wenjing Liu,3 Liyun Sun,1,* Huahao Wang2,* 1Department of Dermatology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100000, People’s Republic of China ...
Wang W, Du L, Ye H, Liu W, Sun L, Wang H
doaj   +2 more sources

Gentiopicroside improves non-alcoholic steatohepatitis by activating PPARα and suppressing HIF1

Frontiers in Pharmacology
Gentiopicroside (GPS) is a highly water-soluble small-molecule drug and the main bioactive secoiridoid glycoside of Gentiana scabra that has been shown to have hepatoprotective effects against non-alcoholic steatohepatitis (NASH), a form of non-alcoholic
Chaoyuan Huang, Chaoyuan Huang, Chaoyuan Huang, Qiuhong Yong, Qiuhong Yong, Yihui Lu, Yihui Lu, Lu Wang, Yiyuan Zheng, Lina Zhao, Peiwu Li, Chong Peng, Wei Jia, Wei Jia, Fengbin Liu, Fengbin Liu   +15 more
doaj   +3 more sources

Mechanisms of breast cancer treatment using Gentiana robusta: evidence from comprehensive bioinformatics investigation [PDF]

Scientific Reports
This study investigates the potential treatment of breast cancer utilizing Gentiana robusta King ex Hook. f. (QJ) through an integrated approach involving network pharmacology, molecular docking, and molecular dynamics simulation.
Bo Xiong, Xinxin Zhang, Dongzhi Sangji, Lianghong Ni, Mingjie Fan, Beibei Fan   +5 more
doaj   +2 more sources

Gentiopicroside Reduces Pain, Pruritus, and Corticosteroid Addictive Dermatitis [PDF]

Natural Product Communications, 2019
Corticosteroid addictive dermatitis (CAD) has rapidly emerged as a health problem which is difficult to cure. The dermatitis control is general with the tacrolimus, pimecrolimus, and antihistamines, and these synthetic drugs are likely to have some side ...
Chaoqun Zhou, Weijian Deng, Guanggang Xiang, Xuhong Lin, Lei An   +4 more
doaj   +2 more sources

Gentiopicroside improves high-fat diet-induced NAFLD in association with modulation of host serum metabolome and gut microbiome in mice

Frontiers in Microbiology, 2023
ObjectiveThe incidence of non-alcoholic fatty liver disease is increasing every year, and there is growing evidence that metabolites and intestinal bacteria play a causal role in NAFLD.
Lijuan Wang, Yuxin Jiang, Qian Yu, Chunping Xiao, Jin Sun, Lili Weng, Ye Qiu   +6 more
doaj   +1 more source

Environmental impact on the variability in quality of Gentiana rigescens, a medicinal plant in southwest China

Global Ecology and Conservation, 2020
Medicinal plants play an important role in traditional medicine and new drug development, but the increased use of wild plant-based traditional medicine presents a potential biodiversity conservation threat.
Ji Zhang, Zhenxian Zhang, Yuanzhong Wang, Yingmei Zuo, Chuantao Cai   +4 more
doaj   +1 more source

Gentiopicroside Ameliorates Diabetic Renal Tubulointerstitial Fibrosis via Inhibiting the AT1R/CK2/NF-κB Pathway

Frontiers in Pharmacology, 2022
Renal tubulointerstitial fibrosis (TIF), characterized by epithelial-to-mesenchymal transition (EMT) of renal tubular epithelial cells, is the typical pathological alteration in diabetic nephropathy.
Zhanchi Xu, Zhanchi Xu, Meng Zhang, Yu Wang, Rui Chen, Shiyue Xu, Xiaohong Sun, Yan Yang, Zeyuan Lin, Shaogui Wang, Heqing Huang   +10 more
doaj   +1 more source

Development of Lipid-Based Gastroretentive Delivery System for Gentian Extract by Double Emulsion–Melt Dispersion Technique

Pharmaceutics, 2021
Gentian (Gentiana lutea L., Gentianaceae) root extract (GRE) is used for the treatment of gastrointestinal disorders. However, its bioactive potential is limited in conventional forms due to the low bioavailability and short elimination half-life of the ...
Jelena Mudrić, Katarina Šavikin, Ljiljana Đekić, Stefan Pavlović, Ivana Kurćubić, Svetlana Ibrić, Jelena Đuriš   +6 more
doaj   +1 more source

Restoration of Immune Homeostasis: The Role of miR-30b-5p and Notch Signaling in Uveitis After Treatment With Longdan Xiegan Decoction. [PDF]

Mediators Inflamm
Uveitis is an inflammatory eye disease, and Longdan Xiegan Decoction (LXD) has been used to treat uveitis. However, the underlying mechanisms have not fully been addressed. The present study aimed to provide new insights into LXD ameliorating inflammatory response of experimental autoimmune uveitis (EAU) and regulating T helper (Th) cell ...
Qiu Y, Yin X, Guo L, Wang B, Zhang M, Xu S, Wei H, Liu B, Gao Y, Bi H, Guo D.   +10 more
europepmc   +2 more sources