Results 21 to 30 of about 806 (159)

Transcriptional Responses and Gentiopicroside Biosynthesis in Methyl Jasmonate-Treated Gentiana macrophylla Seedlings. [PDF]

PLoS ONE, 2016
Gentiana macrophylla, a medicinal plant with significant pharmacological properties, contains the bioactive compound gentiopicroside. Methyl jasmonate (MeJA) is an effective elicitor for enhancing the production of such compounds.
Xiaoyan Cao, Xiaorong Guo, Xinbing Yang, Huaiqin Wang, Wenping Hua, Yihan He, Jiefang Kang, Zhezhi Wang   +7 more
doaj   +1 more source

Gentiopicroside ameliorates CCl-induced liver injury in mice by regulating the PPAR-γ/Nrf2 and NF-κB/IκB signaling pathways

Journal of International Medical Research, 2023
Objective This study explored the mechanisms by which gentiopicroside protects against carbon tetrachloride (CCl 4 )-induced liver injury. Methods Male mice were randomly assigned to the control; CCl 4 ; bifendate 100 mg/kg; or gentiopicroside 25, 50, or
Yun Zhang, Shiguang Pan, Shiming Yi, Jin Sun, Haitao Wang   +4 more
doaj   +1 more source

Environmental impact on the variability in quality of Gentiana rigescens, a medicinal plant in southwest China

Global Ecology and Conservation, 2020
Medicinal plants play an important role in traditional medicine and new drug development, but the increased use of wild plant-based traditional medicine presents a potential biodiversity conservation threat.
Ji Zhang, Zhenxian Zhang, Yuanzhong Wang, Yingmei Zuo, Chuantao Cai   +4 more
doaj   +1 more source

Jian-Zhi Sun, Xin Lv, Shi-Zhao Xu and Qian Cai

Pakistan Journal of Pharmaceutical Sciences, 2022
Gentiana Radix is one of the most often used drugs in traditional Chinese medicine. Stir frying with yellow wine is the most common processing method.
doaj   +1 more source

Gentiopicroside modulates glucose homeostasis in high-fat-diet and streptozotocin-induced type 2 diabetic mice

Frontiers in Pharmacology, 2023
Gluconeogenesis is closely related to the occurrence and development of type 2 diabetes mellitus (T2DM). Gentiopicroside (GPS) is the main active secoiridoid glycoside in Gentiana manshurica Kitagawa, which can improve chronic complications associated ...
Xing Wang, Dongmei Long, Xianghong Hu, Nan Guo   +3 more
doaj   +1 more source

Gentiopicroside Ameliorates Diabetic Renal Tubulointerstitial Fibrosis via Inhibiting the AT1R/CK2/NF-κB Pathway

Frontiers in Pharmacology, 2022
Renal tubulointerstitial fibrosis (TIF), characterized by epithelial-to-mesenchymal transition (EMT) of renal tubular epithelial cells, is the typical pathological alteration in diabetic nephropathy.
Zhanchi Xu, Zhanchi Xu, Meng Zhang, Yu Wang, Rui Chen, Shiyue Xu, Xiaohong Sun, Yan Yang, Zeyuan Lin, Shaogui Wang, Heqing Huang   +10 more
doaj   +1 more source

Development of Lipid-Based Gastroretentive Delivery System for Gentian Extract by Double Emulsion–Melt Dispersion Technique

Pharmaceutics, 2021
Gentian (Gentiana lutea L., Gentianaceae) root extract (GRE) is used for the treatment of gastrointestinal disorders. However, its bioactive potential is limited in conventional forms due to the low bioavailability and short elimination half-life of the ...
Jelena Mudrić, Katarina Šavikin, Ljiljana Đekić, Stefan Pavlović, Ivana Kurćubić, Svetlana Ibrić, Jelena Đuriš   +6 more
doaj   +1 more source

Preparation, Characterization, and In Vivo Evaluation of Gentiopicroside-Phospholipid Complex (GTP-PC) and Its Self-Nanoemulsion Drug Delivery System (GTP-PC-SNEDDS)

Pharmaceuticals, 2023
The objective of the present study was to develop a gentiopicroside-phospholipid complex (GTP-PC) and its self-nanoemulsion drug delivery system (GTP-PC-SNEDDS) to increase the oral bioavailability of gentiopicroside (GTP).
Yingpeng Tong, Wen Shi, Qin Zhang, Jianxin Wang   +3 more
doaj   +1 more source

The distribution, uses, and characteristic components of gentianaceae plants in China

World Journal of Traditional Chinese Medicine, 2021
Extracts of Gentianaceae herbs have been widely used as food additives, teas, or medicinal remedies for various human diseases and disorders. Iridoids, secoiridoids, and analogs glycosides, mainly include gentiopicroside, sweroside, swertiamarin, and ...
Han Cheng, Yue-Bin Ge, Jun Li, Yan Zhang, Xian-Ju Huang, Guo-Xun Chen   +5 more
doaj   +1 more source

Engineering of gentiopicroside-producing yeast strain using low-energy ion implantation mediated synthetic biology

Biotechnology & Biotechnological Equipment, 2016
To obtain an alternative source for the production of gentiopicroside, here genomic DNA segments of the medicinal plant Gentiana macrophylla were randomly transferred into Hansenula polymorpha by 25 KeV nitrogen ions (N+) at a dose of 2.5 × 1016 ions/cm2
Ting Wang, Weidong Qian, Yunfang Fu, Changlong Cai, Peihong Mao   +4 more
doaj   +1 more source