Gentiopicroside inhibits HMGCR/NF-κB pathway to alleviate renal fibrosis [PDF]
BMC Complementary Medicine and TherapiesBackground Gentiopicroside (GSP) has been shown to effectively ameliorate renal fibrosis (RF), yet its underlying mechanisms are poorly characterized. This study investigates how GSP alleviates RF using RNA-seq and in vitro experiments.
Qingqing Xu +5 more
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Gentiopicroside—An Insight into Its Pharmacological Significance and Future Perspectives
Cells, 2023 Gentiopicroside (GPS) is a leading component of several plant species from the Gentianaceae botanical family. As a compound with plenty of biological activities and a component of herbal drugs, GPS has an important role in the regulation of physiological
Lemonia Antoniadi +6 more
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Altitude-dependent accumulation of gentiopicroside in Gentiana rigescens
HeliyonMany terpenoids are synthesized by specific plant taxa in response to particular ecological situations. Gentiopicroside is a secoiridoid glycoside belonging to the broader class of iridoid-derived monoterpenoids, and occurs mainly in plants of the genus ...
Yingmei Zuo +3 more
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Gentiopicroside alleviates type 2 diabetes mellitus by attenuating oxidative stress and reshaping gut microbiota in high-fat diet and streptozotocin-induced mice [PDF]
Frontiers in NutritionIntroductionThe rising incidence of T2DM, along with the limited efficacy and side effects of current drugs, demands new therapies. Gentiopicroside (GPS) has been shown to improve T2DM and its chronic complications; however, whether these effects are ...
Xing Wang +8 more
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Gentiopicroside Attenuates Lithium/Pilocarpine-Induced Epilepsy Seizures by Down-Regulating NR2B/CaMKII/CREB and TLR4/NF-κB Signaling Pathways in the Hippocampus of Mice [PDF]
PharmaceuticalsBackground: Epilepsy is a prevalent and disabling neurological condition characterized by recurrent seizures. Approximately 50% of adults with active epilepsy have at least one comorbidity and they are at a greater risk of premature death than the ...
Miao-Miao Tian +9 more
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Gentiopicroside improves non-alcoholic steatohepatitis by activating PPARα and suppressing HIF1
Frontiers in PharmacologyGentiopicroside (GPS) is a highly water-soluble small-molecule drug and the main bioactive secoiridoid glycoside of Gentiana scabra that has been shown to have hepatoprotective effects against non-alcoholic steatohepatitis (NASH), a form of non-alcoholic
Chaoyuan Huang +15 more
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Nanodelivery of Gentiopicroside for Inflammatory Skin Lesions: Insights from Psoriasis and Diabetic Foot Ulcers [PDF]
International Journal of NanomedicineWenjie Wang,1 Libo Du,2 Huanfeng Ye,2 Wenjing Liu,3 Liyun Sun,1,* Huahao Wang2,* 1Department of Dermatology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100000, People’s Republic of China ...
Wang W, Du L, Ye H, Liu W, Sun L, Wang H
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Journal of Orthopaedic Surgery and ResearchPurpose This study aimed to evaluate the protective effects of gentiopicroside against lipopolysaccharide-induced chondrocyte inflammation. Methods SW 1353 chondrosarcoma cells were stimulated with LPS (5 μg/ml) for 24 h and treated with different ...
Longfei Li +6 more
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Gentiopicroside Reduces Pain, Pruritus, and Corticosteroid Addictive Dermatitis [PDF]
Natural Product Communications, 2019 Corticosteroid addictive dermatitis (CAD) has rapidly emerged as a health problem which is difficult to cure. The dermatitis control is general with the tacrolimus, pimecrolimus, and antihistamines, and these synthetic drugs are likely to have some side ...
Chaoqun Zhou +4 more
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Frontiers in Microbiology, 2023 ObjectiveThe incidence of non-alcoholic fatty liver disease is increasing every year, and there is growing evidence that metabolites and intestinal bacteria play a causal role in NAFLD.
Lijuan Wang +6 more
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