Results 151 to 160 of about 1,328 (198)

Regulatory mechanisms of Gentiopicroside on human diseases: a brief review

Naunyn-Schmiedeberg's Archives of Pharmacology, 2023
Gentiopicroside (GPS), a single compound isolated from Gentiana lutea L. and the crucial representative of secoiridoid constituent, has been permitted for centuries in traditional Chinese medicine. GPS and its metabolites have been increasingly used in the search for clinical management with therapeutic properties and fewer side effects.
Bin Liu, Feng Pang, Hongsheng Bi, Dadong Guo   +3 more
openaire   +2 more sources

Gentiogenal, a Conversion Product of Gentiopicrin (Gentiopicroside)*

Planta Medica, 1983
The structure of gentiogenal, (+/-)5-formyl-6-methyl-3,4-dihydro-1H,6H-pyrano-[3,4-c-]-pyran-1-one, a conversion product of the aglucone of gentiopicrin (gentiopicroside), isolated from BLACKSTONIA PERFOLIATA (Gentianaceae), was elucidated by (1)H- and (13)C NMR spectroscopic, mass spectrometric and X-ray diffraction methods.
W G, van der Sluis, J M, van der Nat, A L, Spek, Y, Ikeshiro, R P, Labadie   +4 more
openaire   +2 more sources

Metabolomic evidence for the therapeutic effect of gentiopicroside in a corticosterone-induced model of depression

Biomedicine and Pharmacotherapy, 2019
Depression is a disease that seriously threatens the quality of human life. To explore the effect of gentiopicroside on depression, this study investigated the therapeutic effect of gentiopicroside on corticosterone-induced depressionin vivo and in vitro by using metabolomic methods.A total of 36 rats were randomly assigned to three groups: a normal ...
Tao Yao, Qin Cui, Zhichao Liu
exaly   +3 more sources

Biomimetic transformation of gentiopicroside to erythrocentaurin

Chinese Chemical Letters, 2009
Abstract Biomimetic transformation of gentiopicroside was carried out by β-glucosidase at pH 7.0 for 3 days at 37 °C. Two products, erythrocentaurin and 5,6-dihydro-5-formyl-6-methyl-1H,3H-pyrano[3,4-c]pyran-1-one were isolated and identified by 1H NMR, 13C NMR, UV, IR, MS and elemental analyse. The possible mechanisms were discussed.
Cui Ling Wang, Jian Li Liu, Zhu Lan Liu, Xin Sheng Li, Xiao Yong Cao   +4 more
exaly   +2 more sources

Structure of gentiopicroside

Tetrahedron Letters, 1960
Abstract A new formula for the gentiopicroside (I), the principal bitter glucoside of common gentians, is proposed.
L. Canonica, F. Pelizzoni, P. Manitto, G. Jommi   +3 more
openaire   +1 more source

A new iridoid precursor of gentiopicroside

Phytochemistry, 1971
Abstract Two new iridoids have been isolated from some Gentiana species. One of them, named gentioside, acts as an effective precursor of gentiopicroside (II). Its structure (V) comprising features of gentiopicroside and loganin (III) is given. The structure of the second iridoid is probably of the aucubin type.
S. Popov, N. Marekov
openaire   +1 more source

Hepatoprotective effect of gentiopicroside in combination with leflunomide and/or methotrexate in arthritic rats

Life Sciences, 2021
This study aimed to examine whether gentiopicroside (GPS) could exert hepatoprotective effects on leflunomide (LEF)- and/or methotrexate (MTX)-treated arthritic rats through anti-inflammatory and antioxidant pathways.We observed the external symptoms of joints, analysed serum indicators, measured haematological parameters and mRNA levels, and performed
Zhijie, Wan, He, Li, Xiaohan, Wu, Haiyun, Zhao, Ran, Wang, Mengmeng, Li, Jing, Liu, Qingfeng, Liu, Rui, Wang, Xiaotian, Li   +9 more
openaire   +2 more sources

Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats—Comparison with gentiopicroside alone

Journal of Pharmaceutical and Biomedical Analysis, 2007
The pharmacokinetics and bioavailability of gentiopicroside (GPS), an active component of the Gentian plant species, from orally administered decoctions of Gentianae (DG), or in combination with other plants in the prescription of Longdan Xiegan Tang (LXT), was compared in rats with oral administration of GPS alone, using doses adjusted to deliver ...
Chang-hong Wang, Zheng-tao Wang, S W Annie Bligh   +2 more
exaly   +3 more sources

Effect of D-cellobiose on oral bioavailability of gentiopicroside

China Journal of Chinese Materia Medica, 2016
In this study, the effect of D-cellobiose on oral bioavailability of gentiopicroside (GPS) was investigate. The influence of D-cellobiose on GPS was achieved by calculating the residual GPS after being degraded with β-glucosidase or intestinal flora, and the data demonstrated D-cellobiose could inhibit the degradation of GPS in intestines; in ...
Yun-Hao, Dai, Man, Wang, Ya-Nan, Zhu, Lu-Lu, Wang, Jian-Ming, Ju, Zhen-Hai, Zhang   +5 more
openaire   +2 more sources

(±)-Gentiovarisin A and gentiovarisin B, unusual secoiridoid dimer skeletons from gentiopicroside

Fitoterapia, 2022
Gentiana scabra, a famous traditional Chinese medicine (TCM), has been documented in Chinese Pharmacopoeia for the treatment of hepatitis. Its index component gentiopicroside could not be detected in the decoction, which suggested that the quality control of the TCM with this ingredient needs attention.
Ping-Xing, Qi, Shuang-Shuang, Liu, Peng, Zhang, Yan-Qing, Xie, Zhu-Ya, Yang, Afsar, Khan, Lu, Liu   +6 more
openaire   +2 more sources