Results 41 to 50 of about 363,358 (296)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

GEO

, 2017
Introduction to Gene Expression ...
openaire   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

PTPLAD2 and USP49 Involved in the Pathogenesis of Smoke-Induced COPD by Integrative Bioinformatics Analysis

International Journal of COPD, 2020
Qiang Zhang,1 Wei Song,1 Nahemuguli Ayidaerhan,2 Zheng He3 1Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province 110042, People’s Republic of China; 2Department of Pulmonary
Zhang Q, Song W, Ayidaerhan N, He Z
doaj  

Filantrocapitalismo digital en educación: Covid-19, UNESCO, Google, Facebook y Microsoft

Revista Teknokultura, 2020
El propósito de este artículo es analizar nuevas formas de filantrocapitalismo digital en la política educativa a raíz de la pandemia Covid-19. El filantrocapitalismo digital es una hibridación conceptual que unifica principios del capitalismo digital ...
Geo Saura
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Identification of Key Genes Involved in Diabetic Peripheral Neuropathy Progression and Associated with Pancreatic Cancer

Diabetes, Metabolic Syndrome and Obesity, 2020
Liumeng Jian,1,* Guangda Yang2,* 1Department of Neurology, Zengcheng District People’s Hospital of Guangzhou, (BoJi-Affiliated Hospital of Sun Yat-Sen University), Guangzhou, People’s Republic of China; 2Department of Cancer Chemotherapy ...
Jian L, Yang G
doaj  

Observation of geo-neutrinos

Physics Letters B, 2010
Geo-neutrinos, electron anti-neutrinos produced in beta decays of naturally occurring radioactive isotopes in the Earth, are a unique direct probe of our planet's interior. We report the first observation at more than 3$ $ C.L. of geo-neutrinos, performed with the Borexino detector at Laboratori Nazionali del Gran Sasso.
Bellini, G., Benziger, J., Bonetti, S., Avanzini, M. Buizza, Caccianiga, B., Cadonati, L., Calaprice, F., Carraro, C., Chavarria, A., Dalnoki-Veress, F., d'Angelo, D., Davini, S., de Kerret, H., Derbin, A., Etenko, A., Fiorentini, G., Fomenko, K., Franco, D., Galbiati, C., Gazzana, S., Ghiano, C., Giammarchi, M., Goeger-Neff, M., Goretti, A., Guardincerri, E., Hardy, S., Ianni, Aldo, Ianni, Andrea, Joyce, M., Kobychev, V. V., Koshio, Y., Korga, G., Kryn, D., Laubenstein, M., Leung, M., Lewke, T., Litvinovich, E., Loer, B., Lombardi, P., Ludhova, L., Machulin, I., Manecki, S., Maneschg, W., Manuzio, G., Meindl, Q., Meroni, E., Miramonti, L., Misiaszek, M., Montanari, D., Muratova, V., Oberauer, L., Obolensky, M., Ortica, F., Pallavicini, M., Papp, L., Perasso, L., Perasso, S., Pocar, A., Raghavan, R. S., Ranucci, G., Razeto, A., Re, A., Ricci, B., Risso, P., Romani, A., Rountree, D., Sabelnikov, A., Saldanha, R., Salvo, C., Schönert, S., Simgen, H., Skorokhvatov, M., Smirnov, O., Sotnikov, A., Sukhotin, S., Suvorov, Y., Tartaglia, R., Testera, G., Vignaud, D., Vogelaar, R. B., von Feilitzsch, F., Winter, J., Wojcik, M., Wright, A., Wurm, M., Xu, J., Zaimidoroga, O., Zavatarelli, S., Zuzel, G.   +88 more
openaire   +5 more sources

Geo‐electromagnetic research aids geo‐hazard mitigation [PDF]

Eos, Transactions American Geophysical Union, 2002
Some 100 Earth scientists from nine different nations recently gathered in Lerici, Italy; for the Second International Workshop on Geo‐Electro‐Magnetism. While this was not a thematic meeting, most of the 40 papers presented focused on applications of electromagnetic methods to natural or man‐made hazards such as known faults, seismically active ...
M. Chiappini, C. Carmisciano, O. Faggioni   +2 more
openaire   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source