Results 311 to 320 of about 1,535,618 (326)

COMPLEMENT INHIBITION FOR GEOGRAPHIC ATROPHY

Retina, 2023
Supplemental Digital Content is Available in the Text. Complement inhibition for the treatment of geographic atrophy results in a slowing of expansion of a surrogate marker but has no proven effect on functional outcome measures in randomized trials ...
R. Spaide, D. Vavvas
semanticscholar   +1 more source

Pegcetacoplan (Syfovre) for geographic atrophy in age-related macular degeneration.

The Medical letter on drugs and therapeutics, 2023
The FDA has approved the complement C3 inhibitor pegcetacoplan (Syfovre – Apellis) for treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD).

semanticscholar   +1 more source

Investigational drugs inhibiting complement for the treatment of geographic atrophy

Expert Opinion on Investigational Drugs, 2023
Introduction Geographic atrophy (GA) is a progressive form of age-related macular degeneration (AMD) that leads to severe visual impairment and central vision loss.
L. Ferro Desideri, Dmitri Artemiev, Enrico Bernardi, Karin Paschon, S. Zandi, Martin Zinkernagel, R. Anguita   +6 more
semanticscholar   +1 more source

Treatment of geographic atrophy: an update on data related to pegcetacoplan

Current Opinion in Ophthalmology, 2023
Purpose of review Geographic atrophy is an advanced and currently untreatable form of age-related macular degeneration (AMD), which leads to significant compromise of visual function and quality of life.
Sagar B. Patel, J. Heier, V. Chaudhary, C. Wykoff   +3 more
semanticscholar   +1 more source

Structural OCT and OCT angiography biomarkers associated with the development and progression of geographic atrophy in AMD

Graefe's Archive for Clinical and Experimental Ophthalmology
Geographic atrophy (GA) is an advanced, irreversible, and progressive form of age-related macular degeneration (AMD). Structural optical coherence tomography (OCT) and OCT angiography (OCTA) have been largely used to characterize this stage of AMD and ...
Veronica Vallino, Alessandro Berni, Andrea Coletto, Sonia Serafino, F. Bandello, M. Reibaldi, E. Borrelli   +6 more
semanticscholar   +1 more source

Concerning Syfovre Approval for Geographic Atrophy.

JAMA ophthalmology, 2023
This Viewpoint discusses concerns about Syfovre being approved as a treatment to slow the rate of geographic atrophy.
Ira H Schachar
semanticscholar   +1 more source

PHENOTYPIC CHARACTERIZATION OF PREDICTORS FOR DEVELOPMENT AND PROGRESSION OF GEOGRAPHIC ATROPHY USING OPTICAL COHERENCE TOMOGRAPHY

Retina
Supplemental Digital Content is Available in the Text. The identification of nonneovascular retinal pigment epithelium-basal lamina–Bruch membrane splitting represented the main optical coherence tomography phenotype involved in the progression of ...
S. Fragiotta, Chantal Dysli, M. Parravano, R. Sacconi, Federico Fantaguzzi, A. Servillo, Alice Antonella Severo, Beatrice Tombolini, E. Costanzo, Daniele De Geronimo, V. Capuano, E. Souied, Francesco Bandello, Giuseppe Querques   +13 more
semanticscholar   +1 more source

Informing Endpoints for Clinical Trials of Geographic Atrophy.

Annual Review of Vision Science
Geographic atrophy (GA), the non-neovascular advanced form of age-related macular degeneration, remains an important disease area in which treatment needs are currently unmet.
Eleonora M Lad, Monika Fleckenstein, F. Holz, L. Shen, L. V. Priore, Rufino Silva, G. Staurenghi, Nadia K. Waheed, U. Chakravarthy   +8 more
semanticscholar   +1 more source

FUNDUS AUTOFLUORESCENCE IN EXTENSIVE MACULAR ATROPHY WITH PSEUDODRUSEN AND DIFFUSE TRICKLING GEOGRAPHIC ATROPHY

Retina, 2023
Extensive macular atrophy with pseudodrusen shows remarkable clinical and imaging similarities with the diffuse-trickling pattern of geographic atrophy.
Lorenzo Bianco, Alessio Antropoli, A. Arrigo, Alessandro Berni, Lamberto La Franca, A. Saladino, F. Bandello, M. Battaglia Parodi   +7 more
semanticscholar   +1 more source