Results 31 to 40 of about 62,563 (295)
Higher form symmetries and M-theory
Journal of High Energy Physics, 2020 We discuss the geometric origin of discrete higher form symmetries of quantum field theories in terms of defect groups from geometric engineering in M-theory.
Federica Albertini +3 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Sub-Finsler Horofunction Boundaries of the Heisenberg Group
Analysis and Geometry in Metric Spaces, 2021 We give a complete analytic and geometric description of the horofunction boundary for polygonal sub-Finsler metrics, that is, those that arise as asymptotic cones of word metrics, on the Heisenberg group.
Fisher Nate, Golo Sebastiano Nicolussi
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Geometric and cohomological methods in group theory [PDF]
, 2009 Geometric group theory is a vibrant subject at the heart of modern mathematics. It is currently enjoying a period of rapid growth and great influence marked by a deepening of its fertile interactions with logic, analysis and large-scale geometry, and ...
core +3 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Potential Theory on Gromov Hyperbolic Spaces
Analysis and Geometry in Metric Spaces, 2022 Gromov hyperbolic spaces have become an essential concept in geometry, topology and group theory. Herewe extend Ancona’s potential theory on Gromov hyperbolic manifolds and graphs of bounded geometry to a large class of Schrödinger operators on Gromov ...
Kemper Matthias, Lohkamp Joachim
doaj +1 more source
An Inverse Problem in Number Theory and Geometric Group Theory [PDF]
, 2010 This paper describes a new link between combinatorial number theory and geometry. The main result states that A is a finite set of relatively prime positive integers if and only if A = (K-K) \cap N, where K is a compact set of real numbers such that for every real number x there exists y in K with x \equiv y mod 1.
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source