Results 81 to 90 of about 779,272 (286)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Geometric Shape Recognition and Classification [PDF]

Microscopy Microanalysis Microstructures, 1996
Parmi les methodes de reconnaissance et de classification de formes planes, nous avons etudie plus particulierement les methodes geometriques. Nous avons developpe une technique de vectorisation de contours utilisant des points de "forte" courbure. Les formes ainsi resumees peuvent etre comparees a des formes references au moyen de parametres de forme,
Marie-José Labouré, Isabelle Fillère, Michel Jourlin, Jean-Marie Becker   +3 more
openaire   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Morphological variability in wing size and wing shape among species Aphidius absinthi Marshall, A. Rosae haliday and A. Urticae Haliday (Hymenoptera: Braconidae: Aphidiinae) [PDF]

Kragujevac Journal of Science, 2017
In this paper, we applied traditional and geometric morphometric methods to analyze variability in wing size and wing shape among species Aphidius absinthi Marshall, A. rosae Haliday and A. urticae Haliday.
Mitrovski-Bogdanović Ana S., Radojičić Petar M.   +1 more
doaj   +1 more source

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source

Geometric shape parameterization of multidimensional finite non-regular point sets

Омский научный вестник
The paper is devoted to a formal approach to parameterization the geometric shape of spatial point irregular sets in multidimensional Euclidean space.
V. Yu. Yurkov, M. A. Chizhik
doaj   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

Corners-based composite descriptor for shapes

, 2008
In this paper, a composite descriptor for shape retrieval is proposed. The composite descriptor is obtained based upon corner-points and shape region.
Lu, Guojun, Sajjanhar, Atul, Zhang, Dengsheng, Zhou, Wanlei   +3 more
core   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

An Angiosperm Species Dataset Reveals Relationships between Seed Size and Two-Dimensional Shape

Horticulturae, 2019
Datasets containing information on seed size have been published and are currently available. Nevertheless, there is a lack in the literature of a dataset dedicated to seed shape. We present a preliminary version for a dataset on seed morphology based on
Emilio Cervantes, José Javier Martín Gómez, Diego Gutiérrez del Pozo, Luís Silva Dias   +3 more
doaj   +1 more source