Results 41 to 50 of about 11,388 (294)

Geometric thinking in learning distance and angle

Journal of Physics: Conference Series, 2021
AbstractSolid geometry is an essential science that students should master because students encounter it in the real world. Students’ geometric thinking ability is still low because they have difficulty understanding the concepts. The purpose of this study was to determine the comparison of the achievement and increase in geometric thinking skills of ...
openaire   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Geometric Imagination as a Factor of Thinking

, 2021
This article focuses on the development of geometric thinking in mathematics lessons in general education schools in the study of geometric objects, the implementation of the relationship between laws and geometry through speech.
Sapoyevich, J. Q. (Jumaniyozov), Elmurodov Jamshid Asatillayevich, Jumaniyozov Qudrat Sapoyevich, Asatillayevich, E. J. (Elmurodov)   +3 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Perception of Symmetry and Spatial Reasoning in 11–12-Year-Old Pupils

Education Sciences
Visual perception and visualization are crucial in mathematical thinking and, more importantly, in geometric thinking. Our research study aimed to follow the link of geometric transformations, mental rotation, spatial ability, and visualisation in ...
Mária Kmetová, Lucia Rumanová
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Developing purposeful mathematical thinking: a curious tale of apple trees [PDF]

, 2012
In this paper I explore aspects of the ways in which school mathematics relates to the “real” world, and argue that this relationship is an uneasy one.
Janet Mary Ainley (7633157), Ainley, Janet   +1 more
core  

Analysis of Van Hiele geometric thinking levels studies in Turkey: A Meta-synthesis study: Van Hiele geometric thinking levels

, 2022
Geometry is an important part of the mathematics curriculum. In the late 1950s, Pierre van Hiele and Dina van Hiele-Geldof developed a theory of learning geometry. Theory helps determine students' geometric thinking levels, design appropriate instruction
Sert- Çelik, Hülya, Kaleli Yılmaz, Gül   +1 more
core  

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source