Results 51 to 60 of about 3,088,125 (319)

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Optimization of voids in concrete ceilings: A geometrical approach [PDF]

FME Transactions, 2019
The task to reduce the material consumption in the building industry is urgent. Conserving concrete saves nature and money. To reduce the consumption of concrete in buildings we design hollow bodies in ceiling structures.
Noack Kevin, Eichenauer Friedrich Martin, Lordick Daniel   +2 more
doaj  

Geometry in Transition: A Model of Emergent Geometry [PDF]

Physical Review Letters, 2008
We study a three matrix model with global SO(3) symmetry containing at most quartic powers of the matrices. We find an exotic line of discontinuous transitions with a jump in the entropy, characteristic of a 1st order transition, yet with divergent critical fluctuations and a divergent specific heat with critical exponent $ =1/2$.
Delgadillo-Blando, Rodrigo, O'Connor, Denjoe, Ydri, Badis   +2 more
openaire   +3 more sources

Hamilton Geometry - Phase Space Geometry from Modified Dispersion Relations

, 2018
Quantum gravity phenomenology suggests an effective modification of the general relativistic dispersion relation of freely falling point particles caused by an underlying theory of quantum gravity. Here we analyse the consequences of modifications of the
Barcaroli, Leonardo, Brunkhorst, Lukas K., Gubitosi, Giulia, Loret, Niccoló, Pfeifer, Christian   +4 more
core   +1 more source

Stanilov-Tsankov-Videv Theory [PDF]

, 2007
We survey some recent results concerning Stanilov-Tsankov-Videv theory, conformal Osserman geometry, and Walker geometry which relate algebraic properties of the curvature operator to the underlying geometry of the manifold.Comment: This is a ...
Brozos-Vazquez, M., Fiedler, B., Garcia-Rio, E., Gilkey, P., Nikcevic, S., Stanilov, G., Tsankov, Y., Vazquez-Lorenzo, R., Videv, V.   +8 more
core   +6 more sources

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

The Geometry of Generations [PDF]

Communications in Mathematical Physics, 2015
We present an intriguing and precise interplay between algebraic geometry and the phenomenology of generations of particles. Using the electroweak sector of the MSSM as a testing ground, we compute the moduli space of vacua as an algebraic variety for multiple generations of Standard Model matter and Higgs doublets.
Michael Stillman, Vishnu Jejjala, Yang-Hui He, Yang-Hui He, Yang-Hui He, Brent D. Nelson, Brent D. Nelson, Cyril Matti   +7 more
openaire   +4 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Observations on holographic aspects of four-dimensional asymptotically flat N $$ \mathcal{N} $$ = 2 black holes

Journal of High Energy Physics, 2022
In this note, we explore holographic attributes of four-dimensional near-extremal Reissner-Nordstrom black hole solutions in ungauged N $$ \mathcal{N} $$ = 2 supergravity theories at the two-derivative level by recasting them as a specific first-order ...
Pedro Aniceto, Gabriel Lopes Cardoso, Suresh Nampuri   +2 more
doaj   +1 more source