Results 61 to 70 of about 3,122,764 (234)

Hamilton Geometry - Phase Space Geometry from Modified Dispersion Relations

open access: yes, 2018
Quantum gravity phenomenology suggests an effective modification of the general relativistic dispersion relation of freely falling point particles caused by an underlying theory of quantum gravity. Here we analyse the consequences of modifications of the
Barcaroli, Leonardo   +4 more
core   +1 more source

Electroweak Vacuum Geometry [PDF]

open access: yes, 1999
We analyse symmetry breaking in the Weinberg-Salam model paying particular attention to the underlying geometry of the theory. In this context we find two natural metrics upon the vacuum manifold: an isotropic metric associated with the scalar sector ...
Kibble, T. W. B., Lepora, Nathan F.
core   +3 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

The genetics of geometry [PDF]

open access: yesProceedings of the National Academy of Sciences, 2004
Although much progress has been made in understanding how gene expression patterns are established during development, much less is known about how these patterns are related to the growth of biological shapes. Here we describe conceptual and experimental approaches to bridging this gap, with particular reference to plant development where lack of cell
Coen, Enrico   +4 more
openaire   +3 more sources

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

open access: yesFEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Observations on holographic aspects of four-dimensional asymptotically flat N $$ \mathcal{N} $$ = 2 black holes

open access: yesJournal of High Energy Physics, 2022
In this note, we explore holographic attributes of four-dimensional near-extremal Reissner-Nordstrom black hole solutions in ungauged N $$ \mathcal{N} $$ = 2 supergravity theories at the two-derivative level by recasting them as a specific first-order ...
Pedro Aniceto   +2 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

A Robust and Accurate Landing Methodology for Drones on Moving Targets

open access: yesDrones, 2022
This paper presents a framework for performing autonomous precise landing of unmanned aerial vehicles (UAVs) on dynamic targets. The main goal of this work is to design the methodology and the controlling algorithms that will allow multi-rotor drones to ...
Assaf Keller, Boaz Ben-Moshe
doaj   +1 more source

Non-commutative geometry, dynamics, and infinity-adic Arakelov geometry [PDF]

open access: yes, 2003
In Arakelov theory a completion of an arithmetic surface is achieved by enlarging the group of divisors by formal linear combinations of the ``closed fibers at infinity''.
Consani, Caterina, Marcolli, Matilde
core   +1 more source

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