Results 61 to 70 of about 42,080 (309)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Geology and geodiversity of the Folafótur peninsula (Westfjords, Iceland)

Journal of Maps, 2023
Geological and geomorphological field surveys and mapping have been carried out in the Folafótur peninsula (Westfjords, Iceland), a remote territory characterized by spectacular landscapes resulting from the interaction of volcanic, tectonic, and glacial
Alessandro Ellero, Björn Oddsson, Giuseppe Ottria   +2 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Geomorphological map of Kvadehuksletta, Brøggerhalvøya (Svalbard, Norway)

Geografia Fisica e Dinamica Quaternaria, 2023
We present a detailed geomorphological map of Kvadehuksletta at the scale of 1:8000, a strandflat on the north-western tip of the Br.gger peninsula in western Spitsbergen. The map is based on remote sensing data and shows how marine, fluvial, glacial, lacustrine, and periglacial processes left their traces in the geomorphological record.
Sassenroth, Cynthia, Salvatore, Maria Cristina, Hauber, Ernst, Bucher, Tilman, Baroni, Carlo   +4 more
openaire   +3 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Spontaneously abandoned settlements in Serbia: Part 2 [PDF]

Zbornik Radova: Geografski institut "Jovan Cvijić", 2011
This is the second part of the article “Spontaneously abandoned settlements in Serbia”, the first part of which was published in No. 60-2 of this Journal.
Milošević Marko V., Milivojević Milovan, Ćalić Jelena   +2 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Geomorphological Mapping and Social Sciences: A Qualitative Review

Geosciences
The number of publications in the scientific literature dealing with geomorphological mapping has increased over the last two decades. Although geomorphological maps are utilised in various contexts, such as hazard assessment, archaeology, and tourism ...
Laura Franceschi, Alberto Bosino, Manuel La Licata, Mattia De Amicis   +3 more
doaj   +1 more source

Space-weighted seismic attenuation mapping of the aseismic source of Campi Flegrei 1983-84 unrest [PDF]

, 2017
Peer reviewedPublisher ...
Amoruso, A, Castellano, M, Crescentini, L, De Siena, L, Del Pezzo, E, Wakeford, Z   +5 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source