Results 61 to 70 of about 42,320 (308)

Vulnerability assessment of the karst aquifer feeding the Pertuso Spring (Central Italy): comparison between different applications of COP method [PDF]

, 2017
Karst aquifers vulnerability assessment and mapping are important tools for improved sustainable management and protection of karst groundwater resources.
DE FILIPPI, FRANCESCO MARIA, Ferranti, Flavia, Sappa, Giuseppe   +2 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Geology and geodiversity of the Folafótur peninsula (Westfjords, Iceland)

Journal of Maps, 2023
Geological and geomorphological field surveys and mapping have been carried out in the Folafótur peninsula (Westfjords, Iceland), a remote territory characterized by spectacular landscapes resulting from the interaction of volcanic, tectonic, and glacial
Alessandro Ellero, Björn Oddsson, Giuseppe Ottria   +2 more
doaj   +1 more source

Geomorphological map of Kvadehuksletta, Brøggerhalvøya (Svalbard, Norway)

Geografia Fisica e Dinamica Quaternaria, 2023
We present a detailed geomorphological map of Kvadehuksletta at the scale of 1:8000, a strandflat on the north-western tip of the Br.gger peninsula in western Spitsbergen. The map is based on remote sensing data and shows how marine, fluvial, glacial, lacustrine, and periglacial processes left their traces in the geomorphological record.
Sassenroth, Cynthia, Salvatore, Maria Cristina, Hauber, Ernst, Bucher, Tilman, Baroni, Carlo   +4 more
openaire   +3 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Geomorphological Mapping and Social Sciences: A Qualitative Review

Geosciences
The number of publications in the scientific literature dealing with geomorphological mapping has increased over the last two decades. Although geomorphological maps are utilised in various contexts, such as hazard assessment, archaeology, and tourism ...
Laura Franceschi, Alberto Bosino, Manuel La Licata, Mattia De Amicis   +3 more
doaj   +1 more source

Spontaneously abandoned settlements in Serbia: Part 2 [PDF]

Zbornik Radova: Geografski institut "Jovan Cvijić", 2011
This is the second part of the article “Spontaneously abandoned settlements in Serbia”, the first part of which was published in No. 60-2 of this Journal.
Milošević Marko V., Milivojević Milovan, Ćalić Jelena   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Snow avalanche susceptibility in the eastern hillside of the Aramo Range (Asturian Central Massif, Cantabrian Mountains, NW Spain) [PDF]

, 2018
A detailed snow avalanche susceptibility map of the eastern hillside in the Aramo Range (Cantabrian Mountains) is presented at a scale of 1:25,000. The Aramo Range is one of the major middle-altitude mountains of the Asturian Central Massif.
Beato Bergua, Salvador, Marino Alfonso, José Luis, Poblete Piedrabuena, Miguel Ángel   +2 more
core   +1 more source