Results 81 to 90 of about 42,320 (308)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Mapping relief units and geosites of Seridó UNESCO Global Geopark, Northeastern Brazil

Revista Brasileira de Geomorfologia
The Seridó UNESCO Global Geopark (SUGG) was approved in 2022. In all, the Geopark has 21 geosites, the main interest of which is geomorphological. Despite the importance of the geomorphological heritage in the SUGG territory, the area had not yet been ...
Marco Tulio Mendonca Diniz, George Pereira de Oliveira, Diogo Bernardino Santos de Medeiros, Jucielho Pedro da Silva, Marcos Antonio Leite do Nascimento, Matheus Dantas das Chagas, Antonio Carlos Barros Correa, Vanda Claudino-Sales   +7 more
doaj   +1 more source

Glacial geomorphology of the Gaick, Central Grampians, Scotland

Journal of Maps, 2019
The Gaick is an enigmatic glaciated landscape in the Central Grampians, Scotland, dominated by an expansive dissected plateau. Previous studies have postulated widely differing interpretations of the glacial landforms and current understanding of the ...
Benjamin M. P. Chandler, Sven Lukas, Clare M. Boston, Jon W. Merritt   +3 more
doaj   +1 more source

Remote sensing of tidal networks and their relation to vegetation [PDF]

, 2004
The study of the morphology of tidal networks and their relation to salt marsh vegetation is currently an active area of research, and a number of theories have been developed which require validation using extensive observations. Conventional methods of
Mason, D.C., Scott, T.R.
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Earthquake‐induced landslide scenarios for seismic microzonation. Application to the Accumoli area (Rieti, Italy) [PDF]

, 2019
Scenarios of earthquake-induced landslides are necessary for seismic microzonation (SM) studies since they must be integrated with the mapping of instability areas.
Battaglia, Simona, Della Seta, M., D’Alessandro, F., Esposito, Carlo, Martini, G., Martino, Salvatore, Pallone, F., Troiani, F.   +7 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

GEOMORPHOLOGICAL MAPPING OF A SAHARAN REGION, THE STILL LANDS NORTH EAST SAHARA [PDF]

Analele Universităţii din Oradea: Seria Geografie, 2016
This study is a first in a Saharan region. Following a collaboration between soil scientists and geomorphologists a geomorphological mapping was realized.
Belkacem BOUMARAF, Alain MARRE, Ines SAADI   +2 more
doaj