Results 51 to 60 of about 323,912 (312)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

European consensus on core principles and future priorities for geriatric rehabilitation: consensus statement.

, 2019
PURPOSE In response to the growing recognition of geriatric rehabilitation and to support healthcare providers which need strategies to support older people with frailty who have experienced functional decline, we developed a consensus statement about ...
Gordon, Adam L, Bauer, Jürgen M, Cherubini, Antonio, Grund, Stefan, Landi, Francesco, Bachmann, Stefan, Stuck, Andreas, Schols, Jos M G A, Becker, Clemens, Achterberg, Wilco P, van Balen, Romke   +10 more
core   +1 more source

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang, Shaoxin Tao, Qiujia Wang, Xiaoyu Xu, Hui Yao, Zheng Liu, Dawei Li, Zhandong Qiu, Jinming Han, Jiangwei Xia, Qi Wang, Jun Sun, Kai Shao, Jiao Li, Shishuang Ruan, Yi Zhong, Jun Guo, Shougang Guo, Yue Huang, Guoliang Chai, Tao Jin, Hongyu Zhou, Junwei Hao, Yinan Zhao   +23 more
wiley   +1 more source

Molecular Aspects of Geriatric Pharmacotherapy

Cells
Pharmacotherapy in the geriatric population is one of the greatest challenges in modern medicine. Elderly patients, characterized by multimorbidity and the resulting polypharmacy, are significantly more exposed to adverse drug reactions (ADRs), which ...
Patryk Rzeczycki, Oliwia Pęciak, Martyna Plust, Marek Droździk   +3 more
doaj   +1 more source

A Novel Digital Nutrition Diary for Geriatric Patients at High Risk of Frailty Syndrome

, 2022
Due to the physical, psychological, or socioeconomic changes that accompany aging, many people will be affected by geriatric frailty syndrome, which can lead to multimorbidity and premature death.
Patrick Elfert, Rebecca Diekmann, Andreas Hein, Norbert Rösch, Julia Berndt, Louisa Dierkes, Marco Eichelberg   +6 more
core   +1 more source

Changes in Immune‐Inflammation Status and Prognosis in Pregnancy‐Related Cerebral Venous Thrombosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Distinguishing pathological changes from physiological adaptations in pregnancy‐related cerebral venous thrombosis (CVT) is clinically challenging. This study aimed to characterize coagulation, immune‐inflammation, and dehydration status in these patients and assess their prognostic value.
Xiaoming Zhang, Zilin Xu, Ran Duan, Chunxiao Lu, Da Zhou, Chen Zhou, Ran Meng, Xunming Ji   +7 more
wiley   +1 more source

The Association Between Systemic Immune-Inflammation Index and Postoperative Cognitive Decline in Elderly Patients

Clinical Interventions in Aging, 2022
Wenbin Lu,1,* Keqin Zhang,1,2,* Xinning Chang,1 Xiya Yu,1 Jinjun Bian1 1Faculty of Anesthesiology, Changhai Hospital, Naval Medical University/Second Military Medical University, PLA, Shanghai, 200433, People’s Republic of China; 2Department of ...
Lu W, Zhang K, Chang X, Yu X, Bian J
doaj  

Subjective Cognitive Concerns and Cognitive Trajectories in Parkinson's Disease: Biomarker Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the relationship of subjective cognitive concerns (SCC) with biomarkers of Alzheimer's disease (AD), neurodegeneration, and Parkinson's disease (PD) and domain‐specific cognitive trajectories among cognitively unimpaired persons with de novo PD. Method Cognitively unimpaired participants with SCC (n = 294) and without SCC (
Francesca V. Lopez, Fareshte Erani, Katherine J. Bangen, David G. Coughlin, Douglas Galasko, Kelsey R. Thomas   +5 more
wiley   +1 more source

Diagnostic Dilemma: Investigating Respiratory Symptoms in a Middle‐Aged Smoker

Clinical Case Reports
This case report presents a diagnostic challenge encountered in a 65‐year‐old male admitted with fever, dyspnea, chest pain, and hemoptysis, alongside constitutional symptoms including weight loss, night sweats, and fatigue. Despite initial suspicion for
Nazanin Zeinali Nezhad, Mitra Samareh Fekri, Amirhossein Shahpar, Mohsen Nakhaie, Mana Khazaeli, Mehrdad Farrokhnia, Faranak Salajegheh   +6 more
doaj   +1 more source

Efficacy and Safety of Chemoradiotherapy with Carboplatin and Paclitaxel in Older Adults with Esophageal Cancer

Journal of Cancer Research and Practice
Background: Concurrent chemoradiotherapy (CCRT) using the paclitaxel/carboplatin regimen, as established in the CROSS study, has become a standard neoadjuvant treatment prior to surgery for patients with locally advanced esophageal cancer.
Chung-Hao Ku, Ming-Mo Hou, Chen-Kan Tseng, Kun-Yun Yeh, Chang-Hsien Lu, Wen-Chi Chou   +5 more
doaj   +1 more source