Results 41 to 50 of about 224,238 (268)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang, Shaoxin Tao, Qiujia Wang, Xiaoyu Xu, Hui Yao, Zheng Liu, Dawei Li, Zhandong Qiu, Jinming Han, Jiangwei Xia, Qi Wang, Jun Sun, Kai Shao, Jiao Li, Shishuang Ruan, Yi Zhong, Jun Guo, Shougang Guo, Yue Huang, Guoliang Chai, Tao Jin, Hongyu Zhou, Junwei Hao, Yinan Zhao   +23 more
wiley   +1 more source

Diagnostic Dilemma: Investigating Respiratory Symptoms in a Middle‐Aged Smoker

Clinical Case Reports
This case report presents a diagnostic challenge encountered in a 65‐year‐old male admitted with fever, dyspnea, chest pain, and hemoptysis, alongside constitutional symptoms including weight loss, night sweats, and fatigue. Despite initial suspicion for
Nazanin Zeinali Nezhad, Mitra Samareh Fekri, Amirhossein Shahpar, Mohsen Nakhaie, Mana Khazaeli, Mehrdad Farrokhnia, Faranak Salajegheh   +6 more
doaj   +1 more source

At Crossroads: The Challenges for Geriatric Oncology in India

South Asian Journal of Cancer
A larger percentage of our population is aging healthily and living on to a ripe old age. 60 years of age is taken as cut-off for identifying geriatric population for the purpose of specialized healthcare.
Bipinesh Sansar, Anuj Gupta, Ankita Chitre, Bal Krishna Mishra, Praveen Lakshmanamurthy, Pooja Gupta, Ajit Sahoo, Navneet Kaur, Somnath Dey, Kunal Ranjan Vinayak, Akhil Kapoor   +10 more
doaj   +1 more source

The Association Between Systemic Immune-Inflammation Index and Postoperative Cognitive Decline in Elderly Patients

Clinical Interventions in Aging, 2022
Wenbin Lu,1,* Keqin Zhang,1,2,* Xinning Chang,1 Xiya Yu,1 Jinjun Bian1 1Faculty of Anesthesiology, Changhai Hospital, Naval Medical University/Second Military Medical University, PLA, Shanghai, 200433, People’s Republic of China; 2Department of ...
Lu W, Zhang K, Chang X, Yu X, Bian J
doaj  

Evaluating a Pragmatic Strength Alternative for Frailty Measurement and Assessing Its Predictive Capacity Against Established Frailty Instruments in Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Frailty occurs prematurely in rheumatoid arthritis (RA) and is associated with poor health outcomes. We compared the performance of four frailty instruments, including a pragmatic alternative measure using chair sit‐to‐stand (STS), and evaluated their abilities to predict poor health outcomes.
Kylie E. Riggles, Hannah F. Brubeck, Adrienne D. Tanus, Courtney N. Loecker, Punyasha Roul, Bryant R. England, Elizabeth R. Wahl, James S. Andrews, Namrata Singh, Joshua F. Baker, Patricia P. Katz, Dolores M. Shoback, Jose M. Garcia, Ariela R. Orkaby, Katherine D. Wysham   +14 more
wiley   +1 more source

Efficacy and Safety of Chemoradiotherapy with Carboplatin and Paclitaxel in Older Adults with Esophageal Cancer

Journal of Cancer Research and Practice
Background: Concurrent chemoradiotherapy (CCRT) using the paclitaxel/carboplatin regimen, as established in the CROSS study, has become a standard neoadjuvant treatment prior to surgery for patients with locally advanced esophageal cancer.
Chung-Hao Ku, Ming-Mo Hou, Chen-Kan Tseng, Kun-Yun Yeh, Chang-Hsien Lu, Wen-Chi Chou   +5 more
doaj   +1 more source

Developing and Evaluating a Laboratory‐Based Frailty Index for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical FI. Methods We used data from a single‐center prospective cohort of adult patients with SLE whose baseline visit ...
Grace Burns, Samuel D. Searle, Alexandra Legge   +2 more
wiley   +1 more source

Associations of Rheumatoid Arthritis Disease Activity With Frailty Over Five Years of Follow‐up

Arthritis Care &Research, EarlyView.
Objective To evaluate whether rheumatoid arthritis (RA) disease activity is associated with frailty both in cross‐section and longitudinally. Methods Participants within the Veterans Affairs Rheumatoid Arthritis (VARA) registry enrolled from 2003 to 2022 were included.
Courtney N. Loecker, Yangyuna Yang, Punyasha Roul, Aaron Baraff, Myra S. Schmaderer, Lani Zimmerman, Kaleb Michaud, Namrata Singh, Grant W. Cannon, Gary Kunkel, Ted R. Mikuls, Ariela R. Orkaby, Joshua F. Baker, Bryant R. England, Katherine D. Wysham   +14 more
wiley   +1 more source

The Effect of Long-Term Proton Pump Inhibitor Use on Frailty Syndrome in Elderly Patients

Jurnal Penyakit Dalam Indonesia, 2016
Introduction. Frailty syndrome, the newest elderly health predictor, associated with higher morbidity and mortality. PPI are often used in elderly due to presence of upper gastrointestinal complaints, and relates with polypharmacy as one of the risk ...
Stephanie Dewi, Purwita W Laksmi, Ari Fahrial Syam, Esthika Dewiasty, Euphemia Seto   +4 more
doaj   +1 more source