Results 141 to 150 of about 23,382 (287)

Geriatric oncology: Current state of the science - Invited editorial

, 2013
Since Cancer Forum first focused on geriatric oncology in 2008, our understanding of the needs of this growing population has expanded, along with the evidence base to support and optimise the level and quality of cancer care provided to older ...
Steer, Christopher, Phillips, Jane, Phillips, JL, Steer, C   +3 more
core  

Irradiated Liver Cancer Cell Vaccine Transfected With GM‐CSF Induces Specific and Long‐Lasting Anti‐tumour Immunity Through the Synergistic Effect of Oxidised mtDNA and GM‐CSF

Cell Proliferation, EarlyView.
Song et al. developed an mGM‐CSF‐loaded, liver cancer cell‐based vaccine that potently activated dendritic cells and elicited tumour‐specific T cell responses. Mechanistically, radiation‐induced oxidative damage to mitochondrial DNA in cancer cells triggers the cGAS‐STING pathway in DCs, which synergizes with mGM‐CSF‐driven JAK2‐STAT3 signalling to ...
Zhiruo Song, Yujie Jiang, Yu Zhang, Danyi Ao, Chunjun Ye, Xiya Huang, Yingqiong Zhou, Hanle Yang, Ruolan Xia, Jiayuan Ai, Dandan Wan, Aiping Tong, Yuquan Wei, Xuemei He, Aqu Alu, Xiawei Wei   +15 more
wiley   +1 more source

Hepatocyte TrkB Acts as a Gatekeeper Against MASH‐Related Liver Fibrosis by Suppressing the TGFβ/CCL2 Axis and Macrophage Infiltration

Cell Proliferation, EarlyView.
Hepatocyte TrkB is identified as a critical gatekeeper against MASH‐related fibrosis. Mechanistically, TrkB inhibits the TGFβ/SMAD3/FOS axis to suppress CCL2 secretion, thereby blocking pathogenic macrophage recruitment and ameliorating liver fibrosis.
Yueying Chen, Jiayi Wei, Shuxuan Li, Kefan Yin, Heming Wang, Yicheng Zhao, Shuqiang Weng, Xizhong Shen, Guangqi Song, Changfeng Zhu, Qunyan Yao, Ling Dong   +11 more
wiley   +1 more source

The Hidden Harm of Information Toxicity: Rethinking How We Share Medical Information

Acta Paediatrica, EarlyView.
Amy Trowbridge, Arika Moore, Caroline Hurd   +2 more
wiley   +1 more source

Collagen Type VI Alpha 1 as a Regulator of Redox Homeostasis in Antioxidant‐Enhanced Osteogenesis of Dental Stem Cells

Cell Proliferation, EarlyView.
Under physiological conditions, NAC activates the PI3K‐AKT‐COL6A1 axis to sustain redox balance and enhance osteogenesis. COL6A1 deficiency, however, compromises this axis, inducing oxidative stress and impairing NAC's osteogenic efficacy. ABSTRACT Alveolar bone injury represents a prevalent clinical challenge in dentistry, for which stem cell‐based ...
Zhaosong Meng, Jiacheng Liu, Yue Zhang, Ruimeng Yang, Jingyi Zhang, Haosun Yang, Zheng Wang, Ran Wei, Zhe Li, Shuling Guo, Lizhi Hu, Lei Sui   +11 more
wiley   +1 more source

Competences for Providing Oral Health Care to Care‐Dependent Older Adults—Defining Learning Objectives for the German Undergraduate Dental Curriculum Through a Delphi Study

European Journal of Dental Education, EarlyView.
ABSTRACT Background/Aim One of the largest unmet dental care needs in Germany concerns dependent older people (DOP). The aim of this Delphi study was to define learning objectives (LOs) for the dental curriculum, specifying the skills, abilities, and attitudes necessary to enable and motivate future dentists to provide oral health care to DOP.
Anna‐Lena Hillebrecht, Anna Greta Barbe, Susanne Krämer, Marc Auerbacher, Wiebke Semper‐Hogg, Benedikt C. Spies, Philipp Linde, Cornelia Erfurt‐Berge, Anastassia Kossioni, Erik Farin‐Glattacker, Kerstin Bitter   +10 more
wiley   +1 more source

The current status of geriatric oncology in India. [PDF]

Ecancermedicalscience, 2023
Noronha V, Rao AR, Ramaswamy A, Kumar A, Pillai A, Dhekale R, Krishnamurthy J, Kapoor A, Gattani S, Sehgal A, Kumar S, Castelino R, Mahajan S, Daptardar A, Sonkusare L, Deodhar J, Ansari N, Vagal M, Mahajan P, Timmanpyati S, Nookala M, Chitre A, Narasimhan PN, Banerjee J, Gota V, Banavali S, Badwe RA, Prabhash K.   +27 more
europepmc   +1 more source

A proposed refined definition of acute myeloid leukaemia patients ineligible for intensive therapy: The Integrated Comorbidity–ECOG–Age criteria

British Journal of Haematology, EarlyView.
Daniel Weidl, Myrto Boukovala, Doris Glaser, Bettina Barthel, Lars Bullinger, Michael Heuser   +5 more
wiley   +1 more source

The Effects of Simulation‐Based Interprofessional Education on Oncology Oral Care Competencies Among Dental and Dental Hygiene Students

European Journal of Dental Education, EarlyView.
ABSTRACT Introduction This study applied simulation‐based interprofessional education (IPE) principles to develop an oncology oral care scenario, with the aim of evaluating the intervention's effects on the IPE core competencies of dental and dental hygiene students before their clinical internships. Materials and Methods Twenty‐eight fifth‐year dental
Shin‐Ru Liao, Pei‐Chen Lin, Ai‐Hua Chang, Kun‐Tsung Lee, Peih‐Ying Lu, Hsiao‐Ling Huang, Ju‐Hui Wu   +6 more
wiley   +1 more source

The real issue with geriatric oncology

Cancer Research, Statistics, and Treatment, 2020
Amish D Vora
doaj   +1 more source