Results 31 to 40 of about 23,258 (251)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Surgery in Geriatric Oncology

Bezmiâlem Science
Surgical treatment of older patients with cancer requires careful evaluation of physiological reserve, frailty, concomitant diseases and individual health conditions.
Adem Akçakaya
doaj   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

Development and Implementation of a Geriatric Oncology Interdisciplinary Case–Based Educational Intervention for Cancer Care Providers

JCO Global Oncology
PURPOSETo develop and implement a continuing professional development (CPD) activity focused on geriatric assessment (GA) in oncology for oncologists and geriatricians.
Haydee C. Verduzco-Aguirre, Carolina Gomez-Moreno, Ana P. Navarrete-Reyes, Gretell Henriquez-Santos, Javier Monroy Chargoy, Abigail Mateos-Soria, Juan José Sánchez-Hernández, Alicia Castelo-Loureiro, Liz Hamui-Sutton, Melchor Sánchez-Mendiola, Enrique Soto-Perez-de-Celis   +10 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Associations of Frailty With the Risk of Incident Cancer and Cancer‐Related Mortality in Veterans With Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective This study investigated the association between frailty and cancer incidence and mortality in patients with rheumatoid arthritis (RA). It aimed to identify how frailty influences cancer risk and cancer‐specific outcomes. Methods This retrospective cohort study analyzed data from the Veterans’ Affairs Rheumatoid Arthritis Registry (2002–2023).
Bhavik Bansal, Aaron Baraff, Katherine Wysham, James S. Andrews, Bryant R. England, Ted R. Mikuls, Joshua Baker, Kaleb Michaud, Alexa Meara, Una Makris, Carolyn Presley, Ariela Orkaby, Namrata Singh   +12 more
wiley   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Differences in the symptom experience of older versus younger oncology outpatients: a cross-sectional study

BMC Cancer, 2013
Background Mortality rates for cancer are decreasing in patients under 60 and increasing in those over 60 years of age. The reasons for these differences in mortality rates remain poorly understood.
Cataldo Janine K, Paul Steven, Cooper Bruce, Skerman Helen, Alexander Kimberly, Aouizerat Bradley, Blackman Virginia, Merriman John, Dunn Laura, Ritchie Christine, Yates Patsy, Miaskowski Christine   +11 more
doaj   +1 more source

The oncogeriatric transition in Morocco: health-system challenges and strategic priorities in an aging society

Frontiers in Public Health
BackgroundMorocco is experiencing rapid demographic aging alongside a rising cancer burden, creating structural challenges for the care of older adults with cancer.
Oussama Sabri, Oussama Sabri, Halima Abahssain, Halima Abahssain, Wydad Nadir, Sihame Lkhoyaali, Sihame Lkhoyaali, Saber Boutayeb, Saber Boutayeb, Hind Mrabti, Hind Mrabti, Hassan Errihani, Hassan Errihani   +12 more
doaj   +1 more source

Geriatric Oncology

Bangladesh Medical Journal, 1970
We are growing old. In cancer care, there is no exception. Over one-half of all cancer patients in the United States are over age 60.Elderly represent 12% of the total world population. Over the next 25 years, more than 60% of all cancers diagnosed in people of 55 years old and older in Bangladesh As the number of elderly rise exponentially, we can ...
Kazi Manzur Kader, Shah Md Keramat Ali, Syed Md Akram Hussain   +2 more
openaire   +2 more sources