Results 51 to 60 of about 23,258 (251)

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2‐Mediated DNA Damage Response

Advanced Science, EarlyView.
DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang, Ting Shen, Yanfang Qiu, Wei Zhang, Ziran Zheng, Jiayi Sun, Yuedi Yao, Mianfeng Yao, Jiang Li   +8 more
wiley   +1 more source

Prediction of Long‐Term Prognosis in Patients With Hepatocellular Carcinoma Using the National Clinical Database Risk Calculator

Annals of Gastroenterological Surgery, EarlyView.
This study aimed to determine the value of the National Clinical Database (NCD) risk calculator in predicting surgical outcomes and long‐term prognosis in patients undergoing resection for hepatocellular carcinoma (HCC). We retrospectively analyzed data from 210 patients with HCC who underwent initial hepatic resection, assessing the relationship ...
Mariko Tsukagoshi, Kenichiro Araki, Norio Kubo, Takamichi Igarashi, Shunsuke Kawai, Kei Hagiwara, Kouki Hoshino, Ryo Muranushi, Ken Shirabe   +8 more
wiley   +1 more source

Establishing a Geriatric Oncology Service in a Medium-Sized Swiss Hospital: Preliminary Results from the PRO-PAC Registry Study

healthbook TIMES. Oncology Hematology
# Background Older adults account for a disproportionate burden of cancer-related morbidity and mortality; however, they are often underrepresented in clinical trials and may receive suboptimal or non-individualized care.
Daniel Hasek, Elena D Chiru, Deborah Wirth, Heinz Unger, Andrea Eish, Martina Sonderegger, Marcus Vetter   +6 more
doaj   +1 more source

Age‐Dependent Prognostic Significance of Preoperative Transthyretin After Curative Resection for Stage I–III Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Preoperative malnutrition and systemic inflammation are established determinants of adverse outcomes in colorectal cancer (CRC). Transthyretin (TTR), a rapid‐turnover hepatic protein, reflects both nutritional and inflammatory status; however, its clinical utility may be influenced by age‐ and sex‐related variability.
Ayane Kawata, Yuji Miyamoto, Hiro Nakamura, Takahiko Akiyama, Kota Arima, Katsuhiro Ogawa, Yukiharu Hiyoshi, Masaaki Iwatsuki   +7 more
wiley   +1 more source

Implementation of the first oncogeriatric subunit for breast cancer patients in Poland: rationale, pilot results and perspectives

Nowotwory
INTRODUCTION: Older women constitute a growing proportion of breast cancer patients, yet their care often remainsfragmented and insufficiently adapted to functional status.
Aleksandra Konieczna, Katarzyna Broczek, Małgorzata Meluch, Maria Wojda, Sebastian Szmit, Patrycja Ozdowska, Zbigniew Nowecki, Beata Jagielska   +7 more
doaj   +1 more source

A Comparison of Frailty Indices in Predicting Postoperative Outcomes After Endoscopic Sinus Surgery

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Objective To compare the discriminatory performance of the Risk Analysis Index (RAI) and modified Frailty Index‐5 (mFI‐5) in predicting postoperative outcomes following endoscopic sinus surgery (ESS). Study Design Retrospective cohort study. Methods Adult ESS patients were identified from the ACS‐NSQIP database (2005–2020).
Akshay Warrier, David Remyes, Tenesha Boyd, Ailish Nagpal, Aman M Patel, David W. Wassef, Jean Anderson Eloy   +6 more
wiley   +1 more source

Significant Clinical Improvements Following Arthroscopic Iliopsoas Fractional Lengthening After Total Hip Arthroplasty: A Prospective Multicenter Study

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To prospectively investigate subjective anterior groin pain, patient‐reported outcome measures, complications, reoperation rates, and hip flexion strength after arthroscopic iliopsoas fractional lengthening. Methods From 2023 to 2025, patients with persistent groin pain after total hip arthroplasty refractory to conservative management ...
Brandon Cabarcas, Sanathan Iyer, Sandeep Yanamala, Jason Ina, Alexander Bishop, Adam V. Daniel, Bruce A. Levy, Mario Hevesi   +7 more
wiley   +1 more source

Is it time for comprehensive geriatric assessment to move beyond primary care? The case for targeting medical sub-specialty practice

Israel Journal of Health Policy Research, 2017
Comprehensive geriatric assessment (CGA) as a consultative service for older adults with complex medical and psychosocial challenges has existed for decades.
Laura K. Byerly, G. Michael Harper
doaj   +1 more source

Impact of the comprehensive geriatric assessment on treatment decision in geriatric oncology

BMC Cancer, 2020
Background The comprehensive geriatric assessment (CGA) is the gold standard in geriatric oncology to identify patients at high risk of adverse outcomes and optimize cancer and overall management.
Sandrine Sourdet, Delphine Brechemier, Zara Steinmeyer, Stephane Gerard, Laurent Balardy   +4 more
doaj   +1 more source

GERIATRIC ONCOLOGY- GERIATRIC SYNDROME- COMORBID DISEASES

, 2020
Diagnosis of cancer and cancer death rate is increasing currently. While the geriatric patient group shows a heterogeneous pattern, chronological age does not often correlate with biological age. Geriatric syndromes, comorbidities, concurrent polydrug use, and physical dysfunctions have been commonly seen in patients.
Bulut E. A., Ulusoylar N., SOYSAL P.
openaire   +2 more sources