Results 91 to 100 of about 6,868,011 (264)

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

Advanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu, Simin Bi, Zhechen Liu, Xiaofeng Zhou, Hengwei Qin, Nicola Dalbeth, Minbiao Ji, Yinghui Hua   +7 more
wiley   +1 more source

Autism and the Oral Microbiome: A Systematic Review of Host-microbial Interactions and Diversity

International Dental Journal
Background: Emerging evidence suggests a link between the oral microbiome and autism spectrum disorder (ASD), a neurodevelopmental condition characterised by social and behavioural impairments. The vast microbial reservoirs in the gut complement those of
Kausar Sadia Fakhruddin, Iman Kamal, Tatia Maglaperidze, Anand Marya, Lakshman Samaranayake, Thantrira Porntaveetus   +5 more
doaj   +1 more source

Role of Th17-cell related cytokines in geriatric asthma

Journal of International Medical Research, 2019
Objective This study aimed to investigate the pathogenesis of geriatric asthma through immunoglobulin E (IgE), interleukin-17A (IL-17A), IL-17F, and glucocorticoid receptor-β (GR-β) expression.
Zhang Quan-san, Xu Xiaohong, Li ying, Sun Zhaojia   +3 more
doaj   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Geriatric care in European countries where geriatric medicine is still emerging

, 2020
Purpose: Practicing geriatric medicine is a challenging task since it involves working together with other medical doctors while coordinating a multidisciplinary team.
Bahat, Gülistan, Sieber, Cornel,, Benetos, Athanase,, Petrovic, Mirko, Ekdahl, Anne W.,, Duque, Sofia,, Soulis, George,, Bahat, Gülistan,, Gouiaa, Radhouane, Duque, Sofia, Ekdahl, Anne W., Gouiaa, Radhouane,, Kotovskaya, Yulia, Benetos, Athanase, Kotovskaya, Yulia,, Soulis, George, Petrovic, Mirko,, Lund University., Sieber, Cornel   +18 more
core   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

MEMORY COMPLAINTS AND ACTIVITIES OF DAILY LIVING IN GERIATRIC DEPRESSION: IS THERE A DIFFERENCE BETWEEN EARLY- AND LATE-ONSET DEPRESSION?

Journal of Contemporary Medicine, 2021
Aim: To investigate the cognitive complaints and activities of daily living in patients with geriatric depression. Inter-group comparisons were performed by dividing geriatric depression patients into early- and late-onset subgroups.
Selçuk Özdin, Hasan Dilhan Bingöl
doaj   +2 more sources

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

A systematic review on the efficacy of artificial intelligence in geriatric healthcare: a critical analysis of current literature

BMC Geriatrics
Objective To carry out systematic analysis of existing literature on role of Artificial Intelligence in geriatric patient healthcare. Methods A detailed online search was carried out using search phrases in reliable sources of information like Pubmed ...
Rangraze Imran, Shehla Shafi Khan
doaj   +1 more source

Implementing comprehensive geriatric assessment in an academic hematologic outpatient setting: experiences from medical doctors and patients

Frontiers in Oncology
IntroductionThe incidence of most cancers increases with age and cancer is a leading cause of morbidity and mortality in the older population. Older cancer patients frequently have additional co-morbidities and functional decline, which can substantially
Steven Pierre Hiltgen, Heike A. Bischoff-Ferrari, Heike A. Bischoff-Ferrari, Michael Gagesch, Michael Gagesch, Michael Gagesch, Alexander Kaltenborn, Markus G. Manz, Max J. Rieger, Rahel Schwotzer, Sebastian M. Stolz, Thorsten Zenz, Wiebke Rösler   +12 more
doaj   +1 more source