Results 101 to 110 of about 6,868,011 (264)

Which is the association between patient-related variables and type of hospital discharge in geriatric surgical patients? Findings from a retrospective study. [PDF]

openIntroduzione: I pazienti chirurgici geriatrici spesso presentano condizioni cliniche e sociali che influenzano la destinazione alla dimissione, come la mancanza di supporto sociale o un compromesso stato funzionale preoperatorio. Durante il ricovero,
DASSI, SARA
core  

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

Older HIV-infected adults: complex patients— geriatric syndromes (II)

, 2019
With the widespread adoption of highly active antiretroviral therapy (HAART), HIV infection starts to be considered one of the many chronic illnesses of advanced age. A growing proportion of the affected patients is presently older than 50.
Guaraldi, G., Marzetti, E., Canevelli, M., Bertagnoli, L., Cesari, M., Iannuzzi, P., Ciccone, S.   +6 more
core   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Construction and application of old platform based on patient report outcome

Huli yanjiu, 2023
ObjectiveTo construct old platform（OP） based on Patient Report Outcome（PRO） and study its application effectiveness.MethodsThe geriatric inpatients in the department of geriatrics of Affiliated Hospital of Nantong University were selected as research ...
LIU Xiaoyan, QIN Yi, ZHU Xiaoling, MAO Yuwei, SUN Chi   +4 more
doaj  

Concept of the Foundation of Korean Hospital for the Elderly who have Neuropsychiatric Disorders

, 1998
The population of the elderly and neuropsychiatric elderly patients increases radically, but realistic management in the welfare and medical dimensions are not adequate.
오병훈
core  

Prescribing of neuroleptics for geriatric nursing home patients: a focus on indications and dosing [PDF]

, 1987
dissertationAmerica\u27s elderly is the fastest growing segment of our population and as a result, the demands on the health care system to provide care for these citizens have increased.
Cantu, Thomas Gerard
core  

International Society of Geriatric Oncology Consensus on Geriatric Assessment in Older Patients With Cancer

, 2014
Purpose To update the International Society of Geriatric Oncology (SIOG) 2005 recommendations on geriatric assessment (GA) in older patients with cancer.
Artz, Andrew, Brain, Etienne, Extermann, Martine, Falandry, Claire, Hurria, Arti, Van Leeuwen, Barbara, Wildiers, Hans, Audisio, Riccardo A., Heeren, Pieter, Karnakis, Theodora, Colloca, Giuseppe, Janssen-Heijnen, Maryska L.G., Kenis, Cindy, Mohile, Supriya, Repetto, Lazzaro, Milisen, Koen, Topinkova, Eva, Janssen-Heijnen, Maryska L. G., Flamaing, Johan, Puts, Martine, Van Leeuwen, Barbara; id_orcid   +20 more
core   +1 more source

Two‐Dimensional Conjugated Metal Organic Frameworks with Dual Metal Catalytic Active Sites Enhance POD Activity for Antibacterial Treatment

Advanced Science, EarlyView.
A new class of Cu, Ni bimetallic 2D cMOF (CuNi‐HHTP 2D cMOF) featuring dual catalytic sites and high delocalized electronic structure for boosting POD performance. The CuNi‐HHTP 2D‐cMOF enhances the conversion kinetics of H2O2 to ROS, which subsequently enhances antibacterial activity and accelerates the healing of oral ulcers, with macroscopic wound ...
Yixuan Lu, Qinqin Li, Yumin Chen, Shihan Zhang, Shuai Ding, Yanpei Wang, Youxing Liu, Yaru Guo, Xuliang Deng, Shaojun Guo   +9 more
wiley   +1 more source