Results 131 to 140 of about 190,507 (315)
Advanced Science, EarlyView.A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li +15 more
wiley +1 more source
, 2015 Aims: Are Ambulatory Blood Pressure Monitors (ABPMs) equivalent to nursing measurements of blood pressure (BP) &postural blood pressure? Can ABPMs improve data collection rates for postural BP measurement, improving clinical diagnosis?
Hohenberg, Mark (R18571) +2 more
core
, 2018 Summary: Background: This study investigated unnecessary emergency medical services (EMS) transports by comparing geriatric patients treated and not treated at the emergency department (ED) after EMS transports, and factors associated with lack of ...
Sun Hyu Kim +2 more
core +1 more source
Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy
Advanced Science, EarlyView.A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li +11 more
wiley +1 more source
[Gerodontic consultation service for hospitalized geriatric patients: diagnosis and therapy (II)]
, 2009 The aim of the study was to report on oral, dental and prosthetic conditions as well as therapeutic measures for temporarily institutionalized geriatric patients.
Katsoulis, Joannis +4 more
core
AGING MEDICINE, EarlyView.Frailty was associated with decreased gray and white matter brain volumes in older adults. Synthetic MRI further revealed relaxometry alterations correlated with frailty severity across multiple clinical scales. ABSTRACT Objectives Frailty, a common condition in the elderly, is characterized by a decline in physiological reserves and an increased ...
Yuhui Chen +7 more
wiley +1 more source
Biomarkers of Sarcopenia: Current Status and Future Perspectives
AGING MEDICINE, EarlyView.In this review, we summarize the various biomarkers discovered in recent years, including biochemical, imaging, and physical testing markers. We analyze their advantages and disadvantages and propose potential ways to improve the diagnostic accuracy of biomarkers, as well as future research directions.
Bijin Luo +6 more
wiley +1 more source
Libraries of life: Using life history books with depressed care home residents
, 2006 Depression is a common, and often undetected, psychiatric disorder in geriatric care home residents 1,2. Reminiscence, an independent nursing therapy used by a variety of health and social care professionals, can prevent or reduce depression 14.
Plastow, N A
core
Validation of the Patient Health Questionnaire‐2 (PHQ‐2) in Detecting Depression Among Older Adults
AGING MEDICINE, EarlyView.PHQ‐2 effectively screens for geriatric depression with the optimal cut‐off of 3 points. ABSTRACT Objectives Depression screening tools like the Patient Health Questionnaire‐2 (PHQ‐2) are commonly used to detect depression. However, its performance in elderly populations has been less extensively studied compared to its broader adult use.
Francesco Salis +6 more
wiley +1 more source
AGING MEDICINE, EarlyView.Frailty definitions in Chinese‐language biomedical literature increasingly align with international frameworks, while retaining conceptual diversity, underscoring the need for multidimensional, cross‐cultural research and integration with traditional Chinese medicine for culturally sensitive clinical practice.
Haodong Wei +5 more
wiley +1 more source