Results 201 to 210 of about 1,279,163 (298)

Clinicopathological and molecular heterogeneity of amyloid‐β in unnatural deaths under 70 years: A forensic autopsy–based study

Brain Pathology, EarlyView.
This study investigates amyloid‐beta (Aβ) pathology in a forensic autopsy cohort of relatively young individuals (40–69 years). Using detailed immunohistochemical analyses of multiple Aβ species, we demonstrate marked regional and molecular heterogeneity, particularly within the striatum.
Shojiro Ichimata, Yukiko Hata, Koji Yoshida, Ryo Tanaka, Shigeo Murayama   +4 more
wiley   +1 more source

The impact of frailty on glycaemic control in older adults with type 1 diabetes: An observational study

Diabetic Medicine, EarlyView.
Abstract Aims The type 1 diabetes population is ageing. Frailty is the age‐related physiological decline that occurs across organ systems, increasing the body's vulnerability to stressors. Current consensus‐based guidelines, derived from evidence in type 2 diabetes, prioritise hypoglycaemia avoidance, which increases falls, hospitalisation and ...
Jonathan A. Golding, Scarlett O. Long, Suzy V. Hope, Juliet E. Wright, Ali J. Chakera, Tom J. Levett   +5 more
wiley   +1 more source

Quality of Diabetes Care Among Older Adults in Germany—Results of the Study on Health of Older People 2022/2023 Compared With Previous National Health Surveys

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims The study aims (1) to evaluate the quality of diabetes care considering guideline‐recommended medical therapies, cardiometabolic factors, and self‐management of health behaviours among older adults with diabetes in Germany, and (2) to examine time trends.
Yong Du, Giselle Sarganas, Beate Gaertner, Maike Buchmann, Judith Fuchs, Hannelore Neuhauser, Christin Heidemann   +6 more
wiley   +1 more source

Age‐Specific Associations of Moderate‐to‐Vigorous Physical Activity With Relative and Absolute Risk of Type 2 Diabetes in UK Biobank Participants

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims We assessed the age‐specific associations between moderate‐to‐vigorous physical activity (MVPA) and incident type 2 diabetes. Materials and Methods We included UK Biobank participants with valid accelerometry data without diabetes mellitus at baseline (N = 87 975; 62.7 years [IQR, 55.6–67.9]; 57% women).
Qiuyu Feng, Raymond Noordam, Denghui Hu, Gali Albalak, Ko Willems van Dijk, Diana van Heemst   +5 more
wiley   +1 more source

Sex‐Stratified Associations of DXA‐Derived Adiposity, Regional Fat Distribution and Muscle Power With Incident Hospitalised Cardiovascular Disease in Older Adults: A Prospective Cohort Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To investigate the sex‐stratified associations of DXA‐derived adiposity, regional fat distribution and muscle power with incident hospitalised cardiovascular disease (CVD) in older Chinese adults. Materials and Methods This prospective cohort included 3168 community‐dwelling older adults (1548 men and 1620 women; median age 72.0 years ...
Ting Zhang, Yuan Gao, Yafei Wu, Jason Leung, Timothy Kwok   +4 more
wiley   +1 more source

Bridging Randomized Trial Efficacy and Real‐World Effectiveness in Multiple Myeloma: Integrating Clinical Trials and Real‐World Evidence for Individualized Care

European Journal of Haematology, EarlyView.
ABSTRACT Multiple myeloma (MM) is predominantly a disease of older adults, yet the randomized clinical trials (RCTs) that define standards of care are conducted largely in younger, fitter, and less comorbid populations. This creates a systematic mismatch between the populations generating evidence and those receiving treatment in routine practice ...
Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Santino Caserta, Eugenio Lucia, Graziella D'Arrigo, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Giovanni Tripepi, Fortunato Morabito, Massimo Gentile   +13 more
wiley   +1 more source

Periodontitis and Chronic Conditions in Older Adults: A Scoping Review and Evidence Map of Systematic Reviews

Gerodontology, EarlyView.
ABSTRACT Background Periodontitis is a prevalent chronic inflammatory condition that frequently co‐occurs with systemic chronic diseases. Although older adults experience a high burden of both periodontitis and chronic conditions, the extent to which age‐specific evidence has been synthesised remains unclear.
Manisha Tamrakar, Najith Amarasena, Kym Michelle McCormick, Liana Luzzi, Gloria Mejia   +4 more
wiley   +1 more source

Ageism and Self‐Reported Attitudes Toward Older Adults Following a Multidisciplinary Educational Program Among Health Students: Implications for Geriatric Dentistry Education

Gerodontology, EarlyView.
ABSTRACT Background Preparing future dental professionals to care for an ageing population requires more than knowledge acquisition. While educational interventions may improve attitudes toward older adults, underlying forms of ageism may persist and influence clinical practice.
A. Braud, V. Bloch, P. Maillot, S. Prissette   +3 more
wiley   +1 more source

Towards Integrated Oral Healthcare in Long‐Term Care: Mapping Responsibilities, Coordination, and Organisational Support

Gerodontology, EarlyView.
ABSTRACT Objective (i) to map responsibilities in the provision of oral healthcare for older adults in long‐term care settings (LTCs), (ii) to examine how coordination processes are described, (iii) to analyse how these responsibilities and coordination processes are distributed across professional groups, (iv) to synthesise these findings into a ...
Sarah Mun Yee Koh, Nan Luo, Gerry McKenna, Sayaka Tada   +3 more
wiley   +1 more source