Results 121 to 130 of about 285,790 (386)

Gompertz Law‐Based Biological Age (GOLD BioAge): A Simple and Practical Measurement of Biological Ageing to Capture Morbidity and Mortality Risks

Advanced Science, EarlyView.
The Gompertz law‐based biological age metric (GOLD BioAge) introduces interpretable convenient and interpretable calculations to capture mortality, disease, and frailty risks. Its applications to proteomics and metabolomics (ProtAge and MetAge) demonstrate clinical potential to enhance aging evaluation and prevent age‐related diseases.
Meng Hao, Hui Zhang, Jingyi Wu, Yaqi Huang, Xiangnan Li, Meijia Wang, Shuming Wang, Jiaofeng Wang, Jie Chen, Zhi jun Bao, Li Jin, Xiaofeng Wang, Zixin Hu, Shuai Jiang, Yi Li   +14 more
wiley   +1 more source

Association of angiitis of central nervous system, cerebral amyloid angiopathy, and Alzheimer’s disease: Report of an autopsy case

Vascular Health and Risk Management, 2008
Cédric Annweiler1, Marc Paccalin2, Gilles Berrut3, Caroline Hommet4, Christian Lavigne1, Jean-Paul Saint-André5, Olivier Beauchet11Department of Geriatrics and Internal Medicine, Angers University Hospital, France; 2Department of Geriatrics,
Cédric Annweiler, Marc Paccalin, Gilles Berrut, Caroline Hommet, Christian Lavigne, et al   +5 more
doaj  

The Case for Mobility Assessment in Hospitalized Older Adults: American Geriatrics Society White Paper Executive Summary

Journal of The American Geriatrics Society, 2018
Mobility can be defined as the ability to move or be moved freely and easily. In older adults, mobility impairments are common and associated with risk for additional loss of function.
H. Wald, Ravishankar Ramaswamy, M. Perskin, Lloyd Roberts, Michael Bogaisky, Winnie Suen, Anna Mikhailovich   +6 more
semanticscholar   +1 more source

'Across the pond'—a response to the NICE guidelines for management of multi-morbidity in older people [PDF]

, 2017
No abstract ...
Stott, David J., Young, John
core   +1 more source

ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy

Advanced Science, EarlyView.
Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie, Tianyi Ji, Zixin Wan, Jie Huang, Han Li, Lingjiao Zou, Zhen Yang, Jiarui Li, Yuqi Guan, Lei Ruan, Jinhua Yan, Cuntai Zhang   +11 more
wiley   +1 more source

Prediction of Pharmacokinetics for CYP3A4-Metabolized Drugs in Pediatrics and Geriatrics Using Dynamic Age-Dependent Physiologically Based Pharmacokinetic Models

Pharmaceutics
Background/Objectives: The use of medicines in pediatrics and geriatrics is widespread. However, information on pharmacokinetics of therapeutic drugs mainly comes from healthy adults, and the pharmacokinetic parameters of therapeutic drugs in other age ...
Jing Han, Zexin Zhang, Xiaodong Liu, Hanyu Yang, Li Liu   +4 more
doaj   +1 more source

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source

Does owning a pet protect older people against loneliness? [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.Pet ownership is thought to make a positive contribution to health, health behaviours and the general well-being of older people. More specifically pet ownership is often
A Gilbey, A Steptoe, AL Podberscek, Ann Bowling, AP Dickens, B Headey, BWJH Penninx, C Victor, C Victor, C Victor, C Victor, C Victor, CB Zhong, Christina Victor, CM Guest, CM Masi, CM Perissinotto, D Melzer, D Russel, DL Wells, E Friedmann, FV Wenz, GC Wenger, H Miltiades, IH Stanley, J Bowlby, J Flaherty, J Hippisley-Coc, J Holt-Lunstad, J McNicholas, J McNicholas, JA Udell, Jitka Pikhartova, JM Siegel, JT Cacioppo, JT Cacioppo, L Andersson, LA Peplau, LB Jennings, M Cattan, M Cattan, M Choi, M Kanamori, M Pinquart, MB Holbrook, MI Wallhagen, MM Herrald, MR Banks, MR Banks, N Savikko, NE Mahon, NM Antonacopoulos, P Demakakos, P Raina, R Hagan, RA Findlay, RA Parslow, RB Olsen, RC Thurston, RF Baumeister, RF Gillum, RS Lazarus, RS Wilson, S Borys, T Fokkema, T Tamura, TF Garrity, The European Pet Food Industry, V Burholt   +68 more
core   +2 more sources

Gut Microbiota Modulates Obesity‐Associated Skeletal Deterioration Through Macrophage Aging and Grancalcin Secretion

Advanced Science, Volume 12, Issue 28, July 24, 2025.
Obese gut‐microbiota derived lipopolysaccharides (LPS) induce bone marrow macrophage senescence and GCA secretion via activating TLR4/NF‐κB/MAPKs pathway. Clinically, obese patients are associated with higher serum GCA levels. Mice with depletion of GCA gene show resistance to skeletal deterioration caused by obesity and LPS‐induced chronic ...
Min Huang, Mei Huang, Ling Liu, Fang Yang, Chen He, Yu‐Chen Sun, Yu‐Rui Jiao, Xiang Tang, Jing Hou, Kai‐Xuan Chen, Wen‐Zhen He, Jie Wei, Hui‐Ling Chen, Xia Li, Chao Zeng, Guang‐Hua Lei, Chang‐Jun Li   +16 more
wiley   +1 more source

Common primary headaches in geriatrics

Indian Journal of Pain, 2015
Headaches have become relatively less prevalent in older patients, but still more than fifty percent of people older than 65 years complain about regularly occurring headache. Most of the headaches are primary headaches.
Amitava Rudra, Suman Chatterjee, Subrata Ray   +2 more
doaj   +1 more source