Results 81 to 90 of about 285,516 (355)

Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang, Jianbo Huang, Shuwei Zhang, Sujiao Cao, Fangxue Du, Liqiang Zhou, Li Qiu, Yuanjiao Tang   +7 more
wiley   +1 more source

Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) [PDF]

, 2011
<p>Background: Venous thromboembolic events (VTE), including deep venous thrombosis and pulmonary embolism, are common in older age. It has been suggested that statins might reduce the risk of VTE however positive results from studies of middle ...
A Gaw, A Squizzato, A Squizzato, AD Blann, AG Holst, Allan Gaw, AM Wallace, Ann Rumley, Anton JM de Craen, AW Tsai, CC Yang, CJ Doggen, CJ Packard, D Grady, David J Stott, Dilys J Freeman, DJ Stott, E Ann Brown, Edward S Tobias, FR Rosendaal, FR Rosendaal, GD Lowe, Gordon DO Lowe, HT Sorensen, I Ford, Ian A Greer, Ian Ford, J Shepherd, J Shepherd, J Wouter Jukema, JG Ray, K Lacut, KA Darvall, KI Paraskevas, L Smeeth, M Cushman, Marijke Frölich, Michele Robertson, N Sattar, Naveed Sattar, P Eline Slagboom, P Poredos, RJ Glynn, RJ Glynn   +43 more
core   +4 more sources

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, EarlyView.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Stercoral Perforation of the Sigmoid Colon

International Journal of Gerontology, 2008
Constipation is prevalent among geriatrics living in nursing homes. This is a problem particularly among those with limited mobility and under multiple medications for various illnesses.
An-Yu Tsai, Shou-Tien Chao, Han-Ming Yang   +2 more
doaj   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Balance and Gait Disorders in the Aged Population. Causes, Assessment and Management: A Literature Review

Clinical Interventions in Aging
Patrick Manckoundia,1,2 France Mourey,2 Fabrice Larosa,1 Thomas Renoncourt1,2 1Université Bourgogne Europe, CHU Dijon Bourgogne, Internal Medicine Geriatrics, Dijon, France; 2Université Bourgogne Europe, INSERM, CAPS UMR 1093, Dijon, FranceCorrespondence:
Manckoundia P, Mourey F, Larosa F, Renoncourt T   +3 more
doaj  

Application status quo and thinking of narrative medicine in geriatrics teaching

Guoji laonian yixue zazhi
Narrative medicine emphasizes the social, relational, and psychological dimensions of patient care, fostering students’ development in areas such as empathy, humanistic values, self-reflection, psychological resilience, moral beliefs, professional ...
Huichan Yuan, Yahui Wang, Ruizhen Zhao, Bin Luo, Jing Chen, Kai Lv   +5 more
doaj   +1 more source

Improving end-of-life care in acute geriatric hospital wards using the Care Programme for the Last Days of Life : study protocol for a phase 3 cluster randomized controlled trial [PDF]

, 2015
Background: The Care Programme for the Last Days of Life has been developed to improve the quality of end-of-life care in acute geriatric hospital wards.
Cohen, Joachim, Costantini, Massimo, Deliens, Luc, Smets, Tinne, Van Den Noortgate, Nele, Verhofstede, Rebecca   +5 more
core   +2 more sources

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

Predisposing factors associated with chronic subdural hematoma in adults and elderly adults served in the neuro surgery and geriatrics service at the María Auxiliadora hospital in 2016-2020

, 2022
Marjhory J. Martinez Palomino, Marco A. Melgarejo Mostajo, Willer Chanduví, Rocío Guillen Ponce   +3 more
openalex   +2 more sources