Results 201 to 210 of about 135,756 (330)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Germ Line Transmission of the Cdk4^R24C Mutation Facilitates Tumorigenesis and Escape from Cellular Senescence

, 2002
Sushil G. Rane, Stephen C. Cosenza, Richard V. Mettus, E. Premkumar Reddy   +3 more
openalex   +1 more source

A novel germ line mutation in SOX9 causes familial campomelic dysplasia and sex reversal [PDF]

, 1996
Fergus Cameron
openalex   +1 more source

One Case of a BRCA1 Germ Line Mutation Ovarian Carcinoma Patient Based on Abnormal Immunohistochemistry Finding. [PDF]

Korean J Pathol, 2014
Kim HJ, Park JM, Lee HW, Lee EH, Kim MK.
europepmc   +1 more source

Germ Line Fanconi Anemia Complementation Group C Mutations and Pancreatic Cancer [PDF]

, 2005
Fergus J. Couch, Michele R. Johnson, Kari G. Rabe, Lisa A. Boardman, Robert R. McWilliams, Mariza de Andrade, Gloria M. Petersen   +6 more
openalex   +1 more source

Olaparib Response in a Patient With Platinum-Refractory Germ Cell Tumor Harboring a Somatic <i>BRIP1</i> Mutation. [PDF]

JCO Precis Oncol
Gismondi CBL, Agarwal R, Teixeira MFB, Chehrazi-Raffle A.   +3 more
europepmc   +1 more source

Epidemiological evidence for the role of puberty and immune senescence in Hodgkin lymphoma aetiology from 1992 Danish cases

International Journal of Cancer, EarlyView.
What's New? The understanding of the epidemiological and clinical distinctions between Epstein–Barr virus (EBV)‐positive and EBV‐negative classic Hodgkin lymphoma remains incomplete. Here, the authors generated unique sets of population‐based sex‐ and age‐specific incidence rates of classic Hodgkin lymphoma in Denmark stratified by histological subtype
Klaus Rostgaard, Stephen Hamilton‐Dutoit, Kristina L. Lauridsen, Lisa Ottander, Trine L. Plesner, Peter Hollander, Peter Brown, Lene Sjö, Christoffer Johansen, Peter Kamper, Estrid Høgdall, Francesco d'Amore, Lena Specht, Ruth F. Jarrett, James D. McKay, Martin Hutchings, Lisa L. Hjalgrim, Ingrid Glimelius, Henrik Hjalgrim   +18 more
wiley   +1 more source

Germ cell immunoprofile and KIT exon 17 mutation guide rectification of seminoma misclassified as epithelioid gastrointestinal stromal tumor: A case report. [PDF]

Biomed Rep
Zhang X, Yuan W, Ren L, Xu C, Hou Y.
europepmc   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

A Breast Cancer Patient of Scottish Descent with Germ-Line Mutations in BRCA1 and BRCA2 [PDF]

, 1998
Alexander Liede, Pauline Rehal, Danny Vesprini, Elaine Jack, John Abrahamson, Steven A. Narod   +5 more
openalex   +1 more source