Results 211 to 220 of about 135,756 (330)

LIN‐24 as a Molecular Switch: Dual Cytotoxic and Cytoprotective Roles of an Aerolysin‐Like Protein in C. elegans

Journal of Applied Toxicology, EarlyView.
ABSTRACT LIN‐24, an aerolysin‐like pore‐forming protein in Caenorhabditis elegans, exemplifies how ancient cytolytic mechanisms have evolved into regulated cellular processes. Initially identified for inducing nonapoptotic, engulfment‐dependent cell death in vulval precursor cells, LIN‐24 has emerged as a multifunctional regulator of metabolism, stress
Sharoen Yu Ming Lim
wiley   +1 more source

The <i>Caenorhabditis</i> Gli protein TRA-1 makes a transcriptional activator that promotes spermatogenesis. [PDF]

iScience
Shen Y, Lin SY, Guo Y, Imtiaz J, Corley K, Ellis RE.   +5 more
europepmc   +1 more source

Prevalence of germ-line mutations in cancer genes among pancreatic cancer patients with a positive family history [PDF]

, 2017
Kari G. Chaffee, Ann L. Oberg, Robert R. McWilliams, Neil Majithia, Brian Allen, John Kidd, Nanda Singh, Anne-Renee Hartman, Richard Wenstrup, Gloria M. Petersen   +9 more
openalex   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene.

Blood, 2014
Manchev VT, Hilpert M, Berrou E, Elaib Z, Aouba A, Boukour S, Souquere S, Pierron G, Rameau P, Andrews R, Lanza F, Bobe R, Vainchenker W, Rosa JP, Bryckaert M, Debili N, Favier R, Raslova H.   +17 more
europepmc   +1 more source

Germ-line mutations in p27 ^Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans

, 2006
Natalia S. Pellegata, Leticia Quintanilla‐Martinez, Heide Siggelkow, Elenore Samson, Karin Bink, Heinz Höfler, Falko Fend, Jochen Graw, Michael J. Atkinson   +8 more
openalex   +1 more source

Escaping Constraints to Innovate: Maternal Neofunctionalization in a HoxB4 Duplicate

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Whole‐genome duplication in Xenopus laevis generated duplicated Hox genes that are largely constrained in sequence and developmental expression. However, HoxB4L uniquely acquired maternal expression through cis‐regulatory and protein structural divergence, illustrating how gene duplication enables transcription factors to escape pleiotropic constraints
Júlia de Lima Carvalho, José Caetano Silva‐Filho, Janaina Lima de Oliveira   +2 more
wiley   +1 more source

A patient-derived CABIN1 mutation recapitulates features of idiopathic multicentric Castleman disease in a mouse model. [PDF]

Blood Adv
Laczko D, Tsao P, Pai RA, Zinski J, Gonzalez MV, Mumau MD, Raabe T, Muramatsu H, Pardi N, Kambayashi T, Fajgenbaum DC.   +10 more
europepmc   +1 more source

A Constitutively Active Somatic Mutation of the Human Lutropin Receptor Found in Leydig Cell Tumors Activates the Same Families of G Proteins as Germ Line Mutations Associated with Leydig Cell Hyperplasia [PDF]

, 2003
Takashi Hirakawa, Mario Ascoli
openalex   +1 more source

Structure, function and regulation of mammalian DNA methyltransferase [PDF]

, 1993
A Bolden, A Czank, A Lahm, AD Riggs, C. Lange, D Jahner, D Simon, D. Ingrosso, DV Santi, E Flatau, E Li, F Antequera, F Antequera, GP Pfeifer, GP Pfeifer, GP Pfeifer, J Posfai, J-P Jost, JC Wu, JR Chaillet, K. K. Hubrich, KE Zucker, KR Fox, L Chen, LA Sznyter, M Monk, M Monk, MN Schwartz, P Engler, P Renbaum, R Holliday, R. Lauster, RL Adams, RLP Adams, RR Meehan, S Klimasauskas, SK Howlett, SL Mansour, T Bestor, T Bestor, T Bestor, T Bestor, TH Bestor, TH Bestor, Y Gruenbaum, Y Gruenbaum, Y Uehara   +46 more
core   +1 more source