Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate. [PDF]
The colonial ascidian Botryllus schlosseri continuously regenerates entire bodies in an asexual budding process. The germ line of the newly developing bodies is derived from migrating germ cell precursors, but the signals governing this homing process ...
Bui, Connor +4 more
core +1 more source
Microphysiological Systems of Lymphatics and Immune Organs
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain +2 more
wiley +1 more source
Absence of CDK12 in oocyte leads to female infertility
Transcriptional activity and gene expression are critical for the development of mature, meiotically competent oocytes. Our study demonstrates that the absence of cyclin-dependent kinase 12 (CDK12) in oocytes leads to complete female sterility, as fully ...
Denisa Jansova +9 more
doaj +1 more source
Motivic Milnor fiber of a quasi-ordinary hypersurface [PDF]
Let $f$ be a germ of complex analytic function at $({\mathbf{C}}^{d+1}, 0)$ such that its zero level defines an irreducible germ of quasi-ordinary hypersurface $(S,0)$.
Perez, Pedro Daniel Gonzalez +1 more
core
On the number of branches of real curve singularities
There is presented a method for computing the number of branches of a real analytic curve germ from $R^n$ to $R^m$, where m is greater or equal to n, having a singular point at the origin, and the number of half--branches of the set of double points of ...
Nowel, Aleksandra, Szafraniec, Zbigniew
core +1 more source
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen +9 more
wiley +1 more source
The Emblems of the Album of the Ljubljana Noble Society of St Dismas: Context, Sources, Originality
The article discusses the sources for the iconography of emblems in the Album of the Ljubljana Noble Society of St Dismas (Archive of the Republic of Slovenia, ref. AS 1073, I/1) that has not yet been systematically addressed.
Tine Germ
doaj +1 more source
Sequence-dependent but not sequence-specific piRNA adhesion traps mRNAs to the germ plasm
The conserved Piwi family of proteins and piwi-interacting RNAs (piRNAs) have a central role in genomic stability, which is inextricably linked to germ-cell formation, by forming Piwi ribonucleoproteins (piRNPs) that silence transposable elements.
Anastassios Vourekas +4 more
semanticscholar +1 more source
Localized ultraviolet laser microbeam irradiation of early Drosophila embryos: Fate maps based on location and frequency of adult defects [PDF]
Drosophila embryos were locally irradiated with a 257-nm laser microbeam during blastoderm and germ band stages. Depending on stage and beam diameter (10–30 μm), from 0 to 45 nuclei were exposed to the uv radiation.
Cremer, Christoph +4 more
core +1 more source
From RNA to DNA: How Cargo Identity Reprograms Lipid Nanoparticle Architecture and Function
The evolution of lipid nanoparticles (LNPs) spans from RNA‐LNPs, used in mRNA vaccines, to DNA‐LNPs, ideal for gene therapies. Emerging bionano architectures, decorated with DNA and plasma proteins, pave the way for advanced DNA‐based therapies that are more stable, targeted, and customizable.
Erica Quagliarini +2 more
wiley +1 more source

