Results 51 to 60 of about 459,468 (342)

Primary Germ Cell Tumors of the Mediastinum: 10 Years of Experience in a Tertiary Teaching Hospital

Kaohsiung Journal of Medical Sciences, 2005
Germ cell tumors occur mostly in the gonad. Extragonadal germ cell tumors are rare, and most occur in the retroperitoneum and mediastinum. Primary mediastinal germ cell tumors are often found in the anterior portion of the mediastinum and include ...
Chih-Jen Yang, Meng-Shuan Cheng, Ming-Shyan Huang   +2 more
doaj   +1 more source

Primordial germ cells: the first cell lineage or the last cells standing? [PDF]

, 2015
Embryos of many animal models express germ line determinants that suppress transcription and mediate early germ line commitment, which occurs before the somatic cell lineages are established.
Adkins, Ahlberg, Ahlberg, Alberio, Amemiya, Anderson, Aramaki, Bachvarova, Bachvarova, Bachvarova, Bachvarova, Blackler, Blackler, Blackler, Blauwkamp, Boterenbrood, Brinkmann, Butler, Campolo, Chambers, Chatfield, Colegrave, Coucouvanis, Crother, Dawkins, de Jong, Dixon, Earl, Evans, Extavour, Fabre, Frankenberg, Hellsten, Herpin, Hopf, Houston, Humphrey, Ikenishi, Inman, Irie, Irie, Johnson, Johnson, Johnson, Johnson, Juliano, Kee, Kehler, Keller, Kemp, Kirschner, Kispert, Knaut, Knaut, Kurimoto, Labosky, Lai, Lawson, Leitch, Leitch, Livigni, Loose, Magnúsdóttir, Matsui, McLaren, Michael, Morrison, Nakaki, Nakamura, Niedźwiedzki, Nieuwkoop, Nieuwkoop, Nieuwkoop, Ohinata, Perrett, Rayon, Raz, Sabour, Saitou, Seydoux, Shirae-Kurabayashi, Shook, Shook, Smith, Smith, Solana, Sugawa, Surani, Sutasurja, Swartz, Swiers, Tada, Takahashi, Tapia, Tsunekawa, Valdez Magaña, Vallier, Venkatarama, Wardle, Weber, Weir, Weismann, Wolf, Wourms, Xu, Yamaji, Yu, Zhang   +107 more
core   +2 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Mitochondrial fission regulates germ cell differentiation by suppressing ROS-mediated activation of Epidermal Growth Factor Signaling in the Drosophila larval testis. [PDF]

, 2019
Mitochondria are essential organelles that have recently emerged as hubs for several metabolic and signaling pathways in the cell. Mitochondrial morphology is regulated by constant fusion and fission events to maintain a functional mitochondrial network ...
Jones, D Leanne, Sênos Demarco, Rafael
core   +1 more source

PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation. [PDF]

, 2018
Germ cell tumors (GCTs) are a heterogeneous group of tumors occurring in gonadal and extragonadal locations. GCTs are hypothesized to arise from primordial germ cells (PGCs), which fail to differentiate.
Chen, Di, Clark, Amander T, Gell, Joanna J, Hunt, Timothy J, Zhao, Jasmine   +4 more
core   +2 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

A case report of recurrent testicular germ cell tumor in a patient with a history of primary pulmonary germ cell tumor and a review of the literature

Frontiers in Oncology
BackgroundCompared to testicular germ cell tumors, the incidence of extragonadal germ cell tumors (EGCTs) is relatively low. While the lungs are a common site for metastasis of malignant germ cell tumors, primary pulmonary germ cell tumors are extremely ...
Jian Tan, Jian Tan, Jinfeng Wu, Jinfeng Wu, Runqiang Yuan, Wei Li, Linfeng Li, Hongxing Huang, Hongxing Huang, Yangbai Lu   +9 more
doaj   +1 more source

An Extended Culture System that Supports Human Primordial Germ Cell-like Cell Survival and Initiation of DNA Methylation Erasure. [PDF]

, 2020
The development of an in vitro system in which human primordial germ cell-like cells (hPGCLCs) are generated from human pluripotent stem cells (hPSCs) has been invaluable to further our understanding of human primordial germ cell (hPGC) specification ...
Bower, Grace, Chialastri, Alex, Clark, Amander T, Dey, Siddharth S, Gell, Joanna J, Hancock, Grace, Liu, Wanlu, Sosa, Enrique, Tao, Yu, Wamaitha, Sissy E   +9 more
core  

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Cisplatin-Based Chemotherapy for Pulmonary Metastasized Germ Cell Tumors of the Testis - Be Aware of Acute Respiratory Distress Syndrome [PDF]

, 2009
Background: Cisplatin-based combination chemotherapy is regarded as standard of care for patients with advanced germ cell tumors. In patients with lung metastases and a high tumor load, an association between induction chemotherapy and the development of
Baumann, Anja, Boeck, Stefan, Gallmeier, Eike, Hausmann, Andreas, Metzeler, Klaus H., Parhofer, Klaus G., Stemmler, Hans-Joachim   +6 more
core   +1 more source